Biologically Active Co(II) and Ni(II) Complexes of<i>N</i>‐(2‐Thienylmethylene)‐2‐Aminothiadiazole

Chohan, Zahid H.

doi:10.1155/mbd.2002.323

Cited by 8 publications

(1 citation statement)

References 5 publications

(7 reference statements)

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“…Aminothiadiazoles are a series of compounds with a wide spectrum of biological activity, including antimicrobial, antiviral, antifungal, antituberculosis, anti--inflammatory, anticonvulsant and anti-cancer properties [1][2][3][4][5][6][7][8]. Their ability to inhibit cancer development has been documented in numerous in vitro [7][8][9][10][11] and in vivo [12][13][14][15][16][17][18] studies.…”

Section: Introduction Introduction Introduction Introduction Introducmentioning

confidence: 99%

The activity of a new 2-amino-1,3,4-thiadiazole derivative 4ClABT in cancer and normal cells

Juszczak¹,

Matysiak²,

Niewiadomy³

et al. 2011

Folia Histochem Cytobiol.

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The activity of a new 2-amino-1,3,4-thiadiazole The activity of a new 2-amino-1,3,4-thiadiazole The activity of a new 2-amino-1,3,4-thiadiazole The activity of a new 2-amino-1,3,4-thiadiazole The activity of a new 2-amino-1,3,4-thiadiazole derivative 4ClABT , and T-cell leukemia (Jurkat E6.1), as well as cancers of the nervous system including rhabdomyosarcoma/medulloblastoma (TE671), brain astrocytoma (MOGGCCM) and glioma (C6) was studied by means of MTT assay. DNA synthesis level was determined in BrdU ELISA test. Wound assay model was applied for tumor cell motility assessment. Morphological changes induced by 4ClABT in cancer and normal cells were analyzed in HE staining specimens. Moreover, the influence of 4ClABT on normal cells including skin fibroblasts (HSF), hepatocytes (Fao), astroglia and neurons was studied by means of LDH assay. The tested compound inhibited the proliferation of tumor cells in dose-dependent fashion. The anti-cancer effect was attributed to decreased DNA synthesis, prominent changes in tumor cell morphology as well as reduced cell motility. In antiproliferative concentrations, 4ClABT was not toxic to normal cells. Our study showed prominent anti-cancer effects of the tested aminothiadiazole derivative in the absence of toxicity in normal cells. The obtained results confirmed the promising anti-cancer profile of previously tested 2-(monohalogenphenylamino)--5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazole derivatives (ClABT -chlorophenyl derivative, FABT and 3FABT -fluorophenyl derivatives and 4BrABT -bromophenyl derivative). The molecular mechanisms and the in vivo activity of aminothiadiazole derivatives will be the subject of further studies.

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Section: Introduction Introduction Introduction Introduction Introducmentioning

confidence: 99%

The activity of a new 2-amino-1,3,4-thiadiazole derivative 4ClABT in cancer and normal cells

Juszczak¹,

Matysiak²,

Niewiadomy³

et al. 2011

Folia Histochem Cytobiol.

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Some new biologically active metal-based sulfonamide

Chohan

Shad

Youssoufi

et al. 2010

European Journal of Medicinal Chemistry

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In-vitroantibacterial and cytotoxic activity of cobalt (ii), copper (ii), nickel (ii) and zinc (ii) complexes of the antibiotic drug cephalothin (Keflin)

Chohan

Supuran

2005

Journal of Enzyme Inhibition and Medicinal Chemistry

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Keflin (kefl) interacts with Co(II), Cu(II), Ni(II) and Zn(II) metal ions leading to complexes of the type M(kefl)2Cl2 and M(kefl)Cl2, which have been characterized by physicochemical and spectroscopic methods. Magnetic moment, IR, electronic spectral and elemental analyses data suggest that keflin behaves tridentately forming octahedral or trigonal bipyramidal complexes with the metal ions mentioned above. The new compounds have been screened in-vitro for antibacterial and cytotoxic activity against Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Salmonella typhi, Shigella dysentriae, Bacillus cereus, Corynebacterium diphtheriae, Staphylococcus aureus and Streptococcus pyogenes bacterial strains. Compounds, 4 and 8 showed promising activity (90%) against seven, compound 6 showed significant activity (52%) against four and, compounds 1 and 5 showed activity (40%) against three test bacterial strains at concentration of 10 microM.

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Biologically Active Co(II) and Ni(II) Complexes ofN‐(2‐Thienylmethylene)‐2‐Aminothiadiazole

Cited by 8 publications

References 5 publications

The activity of a new 2-amino-1,3,4-thiadiazole derivative 4ClABT in cancer and normal cells

The activity of a new 2-amino-1,3,4-thiadiazole derivative 4ClABT in cancer and normal cells

Some new biologically active metal-based sulfonamide

In-vitroantibacterial and cytotoxic activity of cobalt (ii), copper (ii), nickel (ii) and zinc (ii) complexes of the antibiotic drug cephalothin (Keflin)

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