Copper deficiency in rats fed upon raw meat

Moore, Thomas; Constable, B. J.; Day, Kenneth C.; Impey, Samuel G.; Symonds, K. R.

doi:10.1079/bjn19640013

Cited by 16 publications

(6 citation statements)

References 19 publications

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“…Mo~re e_t al. ( 11) a~so reported ~nem1a and skeletal abnormalities m young piebald rats gtven a diet of raw beef. The skeletal lesions were attributed mainly to the low-Ca content of the meat.…”

Section: Discussionmentioning

confidence: 99%

Calcium Movement in Barley and Wheat as Affected by Copper and Phosphorus¹

Brown

1965

Agronomy Journal

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Section: Discussionmentioning

confidence: 99%

Calcium Movement in Barley and Wheat as Affected by Copper and Phosphorus¹

Brown

1965

Agronomy Journal

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“…'The deleterious effect of the meat diet on bones of mice may, therefore, partly result from the excess of Zn present in meat, which can be counteracted by Ca or Cu. Recenrly, Moore, Constable, Day, Impey & Symonds (1964) reported that the ash content of femurs of young rats fed for 7 weeks upon meat is Iow. Addition of 5 mg Cu/kg meat increased it only slightly.…”

Section: Discussionmentioning

confidence: 99%

The effect of copper on the mineralization of bones of mice fed on a meat diet

1964

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It has been reported that the bone ash of young mice kept for 6 weeks on a diet composed entirely of muscle meat was markedly reduced ; osteoporosis could be demonstrated radiologically as well as histologically (Ilan, Schwartz & Guggenheim, r962; Ulmansky, 1964). The disorder was completely prevented by the addition of calcium carbonate or, to a lesser degree, by replacement of one-quarter of the meat by beef liver. Since liver contains more copper than muscle, the meat diet was supplemented with 20 mg Cu/kg. This supplement increased considerably the proportion of bone ash. I t is noteworthy that Cu exerted this effect on the mineralization of bone when added to a basal diet, i.e. meat, that is poor in calcium and rich in phosphorus. It was thought that this effect of Cu deserved further investigation. Mice were therefore maintained on a meat diet to which Cu had been added. After various times their femurs were analysed for bone ash, calcium, phosphorus and manganese, and the incorporation of radioactive Ca was measured. METHODS The study involved 432 male Swiss mice. They came from a stock maintained, without inbreeding, at the Hebrew University for over 15 years. They were 3 weeks old and weighed 10-13 g. They were divided into six groups. The diets consisted of raw lean beef muscle, which was offered either unsupplemented (first group) or supplemented with Cu or Ca. Thus, the diets of groups 2-5 were supplemented with 2-5, 5.0, 10.0 and 20.0 mg Cu (as CuSO,)/kg and that of group 6 with 3-6 g Ca (as CaCO,)/kg. A similar supplement (3-3 gfkg) of Ca as CaCO, had previously been found to induce normal mineralization of bones in mice fed on this diet (Ilan et al. 1962; Ulmansky, 1964). The Ca content of the meat was examined in twelve samples and found to be 95 (standard error: 5.9) mg/kg. Twenty-four mice of each group, i.e. one-third, were killed after 2 weeks and twenty-four mice each after 4 and 6 weeks. The femurs were cleaned of adherent tissue and weighed. They were then broken, extracted for 6 h with alcohol in a Soxhlet apparatus, dried to constant weight and ashed at 600'. In the ash, Ca (Baron & Bell, 1959), P (Fiske & Subbarow, 1925) and Mn (Gates & Ellis, 1947) were determined. P and Mn were determined in the bones of eighteen mice only from each group. Measured portions of the ash of three pairs of femurs were pooled. The figures

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“…severe anemia and depigmentation of the fur, which can be com pletely prevented by adding copper to the diet. Cooking of meat, on the other hand, prevents anemia without any copper supplementation obviously by facilitating the release of copper from its binding to pro tein [11]. No signs of hypochromotrichia or other copper deficiency symptoms could be observed in the rats of any group fed the simu lated Finnish diets.…”

Section: Resultsmentioning

confidence: 94%

“…Most experimental studies on meat diets have been made by feeding rats solely upon meat [10][11][12]. Raw meat diets cause e.g.…”

Section: Resultsmentioning

confidence: 99%

Bioevaluation of Dietary Iron in Growing Rats

Ahlström

Koivistoinen

Sytelä³

1970

Ann Nutr Metab

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The effects of three levels (4.3, 8.2 and 15.2%) of meat in simulated Finnish diets on the iron utilization were studied in growing rats of both sexes. Rats fed human diets for sixty days from weaning showed no differences in growth, blood hemoglobin and liver iron, copper and zinc concentration in response to the dietary meat levels. In both sexes the food intakes were the largest at the highest level of meat resulting in the lowest food efficiency ratios. Neither did the rats rendered anemic before being fed human diets show any significant differences in the parameters used in response to the meat levels. The liver iron content was however, significantly lower in female rats at the highest level of dietary meat. It is concluded that in the rat the level of meat in a mixed-type diet does not cause any notable differences in the iron utilization.

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Copper deficiency in rats fed upon raw meat

Cited by 16 publications

References 19 publications

Calcium Movement in Barley and Wheat as Affected by Copper and Phosphorus¹

Calcium Movement in Barley and Wheat as Affected by Copper and Phosphorus¹

The effect of copper on the mineralization of bones of mice fed on a meat diet

Bioevaluation of Dietary Iron in Growing Rats

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Copper deficiency in rats fed upon raw meat

Cited by 16 publications

References 19 publications

Calcium Movement in Barley and Wheat as Affected by Copper and Phosphorus1

Calcium Movement in Barley and Wheat as Affected by Copper and Phosphorus1

The effect of copper on the mineralization of bones of mice fed on a meat diet

Bioevaluation of Dietary Iron in Growing Rats

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Product

Resources

About

Calcium Movement in Barley and Wheat as Affected by Copper and Phosphorus¹

Calcium Movement in Barley and Wheat as Affected by Copper and Phosphorus¹