Copper-containing nanoparticles: Mechanism of antimicrobial effect and application in dentistry-a narrative review

Ma, Xinru; Zhou, Shiyu; Xu, Xiaoling; Du, Qin

doi:10.3389/fsurg.2022.905892

Cited by 65 publications

(41 citation statements)

References 197 publications

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“…In this study, the antifungal efficacy can be explained by a 'contact killing' mechanism of cupric nanoparticles was published by many authors [36,37]. It was proposed that the copper provided a surface for killing bacteria, fungi, and viruses with extensive cell membrane damage, by cell vacuole enlargement and disappearances.…”

Section: Antifungal Activity Of Cunps On Mycelial Growthmentioning

confidence: 82%

Synthesis and antifungal activity of copper nanoparticles against Fusarium oxysporum pathogen of plants

Hạnh

Nguyen

Le³

2023

Mater. Res. Express

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For many decades, Cu2+ ions have been used as fungicides in agriculture. However, the accumulation of Cu2+ ions in the soil ecosystem will be disadvantage for environment. Thus, the substitution of copper nanoparticles for Cu2+ ion is necessary to develop long-term eﬃcient, eco-friendly, and cost-eﬀective fungicides. In this study, the copper nanoparticles were synthesized by chemical reduction method of Cu2+ with reductive agent of NaHB4 in chitosan stabilizer. Characterizations of copper nanoparticles were determined by UV-Vis spectra, Fourier transform infrared spectroscopy, X ray diffraction patterns and Transmission Electron Microscopy images. The antifungal efficacy of CuNPs was evaluated by testing against Fusarium oxysporum fungi at various concentrations from 20 -100 ppm. The results revealed that copper nanoparticles samples inhibited significantly the growth of Fusarium oxysporum and the smaller diameter is, the higher antifungal efficacy is. The copper nanoparticles with 26.5 nm expressed an antifungal efficacy is higher than copper nanoparticles with 29 nm. The complete inhibition was observed at concentrations  80 ppm after 1 day and even 7 days of incubation for 2.0 CuNPs (26.5 nm) sample while fungi still survive on PDA plates containing 1.5 CuNPs (29 nm).

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Section: Antifungal Activity Of Cunps On Mycelial Growthmentioning

confidence: 82%

Synthesis and antifungal activity of copper nanoparticles against Fusarium oxysporum pathogen of plants

Hạnh

Nguyen

Le³

2023

Mater. Res. Express

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“…Current studies a rm that copper-containing NPs are used in dentistry due to their abounding antimicrobial and antibio lm properties which impedes a variety of oral pathogenic microorganisms without causing microbial resistance and also produces favorable effects on oral tissues 12 .…”

Section: Discussionmentioning

confidence: 99%

“…The application of metals as antibacterial substances to curb oral plaque has become a research hotspot, as micro-organisms unveil less resistance against metal antibacterial substances. The different types of copper-containing NPs were incorporated into supporting materials (chitosan, cellulose polymers, hydrogels, etc), which exhibited antimicrobial property and were biocompatible 12 . Hence, in our study we prepared CuNP gel by using Carbopol 934 and copolymers, where its pH was 5.76, the viscosity at room temperature was 322.5 cPs and a spread diameter of 425% displaying easy spread with less stress.…”

Section: Discussionmentioning

confidence: 99%

In vitro assessment of copper nanoparticle gel as a futuristic drug delivery agent against periodontal pathogens

Mahale¹,

Dhadse²,

Mahale³

2023

Preprint

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Background Nanotechnology delivers a novel mode for restricting alveolar infections. The particles intermingle through the bacterial cell wall improving antimicrobial action. Its amalgamation and glazing displayed greater germicidal properties. Arraying nanoparticles show sustained delivery of bactericidal property which ultimately aims the dentinal matrix. This study aimed to in vitro appraise the physical properties, antimicrobial, cytotoxicity, time-kill assay, anti-biofilm formation, and anti-inflammatory and antioxidant activity of Cu nanoparticle gel against periodontal pathogens. Materials & Methods Copper nanoparticles (procured from the Nano Research Laboratory, Jharkhand, India) gel was prepared and assessed for minimum inhibitory and minimum bactericidal concentration, MTT assay (cytotoxicity against periodontal and mouse fibroblasts), and time-kill assay at different time intervals against periodontal pathogens. Antibiofilm formation by the cell culture method, anti-inflammatory activity against MMP-9 using zymography and antioxidant properties by the DPPH assay was assessed. Results The pH of CuNP gel was 5.76 and the viscosity at room temperature was 322.5 cPs. The IC50 value of CuNP for mouse fibroblasts (L939) was 49.12 ± 1.67, and against periodontal fibroblasts was at 3.12 µg/ml, displayed 98% of cell viability. At 1hr, the time-kill assay exhibited no growth of periodontal pathogens when followed for 48 hr. The MIC value at a concentration of 0.4 µg/ml for P.gingivalis, F.nucleatum, P. intermedia, T. forsythia, and at 3.12 µg/ml for A.a were sensitive to CuNP gel. Whereas the MBC value at 0.4 µg/ml to F. nucleatum and T forsythia, at 0.8 µg/ml to P. intermedia, at 1.6 µg/ml to P. gingivalis and at 25 µg/ml to A.a disclosed no growth. Antioxidant assay determined inhibition at 55.6%. Anti-inflammatory and anti-biofilm activity presented weak activity against copper nanoparticle gel as compared to chlorhexidine. Conclusion Copper nanoparticles prepared by biological synthesis are cost-effective, eco-friendly and its in-vivo assessment as local drug delivery in the treatment of periodontal pocket is desired.

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“…Copper and silver nanoparticles, in particular, have been studied extensively for their potential antibacterial effects. [10,11] Comparatively, copper nanoparticles have demonstrated greater effectiveness against E. coli, B. subtilis, and S. aureus when compared to silver nanoparticles. [12,13] Copper has better antibacterial action than silver and is more cost-effective option for nanoparticle synthesize and applications.…”

Section: Introductionmentioning

confidence: 99%

“…Antibiotic resistance is a global concern, with reports indicating that nearly every microbe species or strain is now resistant to at least one antibiotic. Copper and silver nanoparticles, in particular, have been studied extensively for their potential antibacterial effects [10,11] . Comparatively, copper nanoparticles have demonstrated greater effectiveness against E. coli , B. subtilis , and S. aureus when compared to silver nanoparticles [12,13] .…”

Section: Introductionmentioning

confidence: 99%

Development and Characterization of Copper Nanoparticle‐Embedded pH‐responsive Polymeric Microbeads for Drug Delivery and Antibacterial Applications

Rathnam,

Reddy,

Gaikwad

et al. 2023

ChemistrySelect

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Copper nanoparticles have been utilized in a variety of therapeutic applications because of their inexpensive manufacturing and unique characteristics. In the current study, novel nanocomposites are developed to carry bioactive agents in a controlled manner. Copper nanoparticles (Cu‐NPs) were synthesized from copper sulfate using a leaf extract of Phyllanthus virgatus as a reducing agent. The obtained Cu‐NPs are loaded into the polymeric matrix of sodium alginate and locust bean gum to generate microbeads. The developed microbeads were characterized by Fourier‐transform infrared (FTIR), X‐ray diffraction (XRD), transmission electron microscopy (TEM), selected area electron diffraction (SAED), and scanning electron microscope (SEM). Swelling and in vitro release studies were performed at pH 2.0 and 7.4 at 37 °C. Metronidazole (MTD) was used as a model agent, and the antibacterial activity of microbeads was tested against Streptococcus mutans, Klebsiella pneumoniae, and Bacillus subtilis. The release kinetics and MTD release pattern were analyzed by employing the MTD release data into Korsmeyer‐Peppas equation and other kinetic models.

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Copper-containing nanoparticles: Mechanism of antimicrobial effect and application in dentistry-a narrative review

Cited by 65 publications

References 197 publications

Synthesis and antifungal activity of copper nanoparticles against Fusarium oxysporum pathogen of plants

Synthesis and antifungal activity of copper nanoparticles against Fusarium oxysporum pathogen of plants

In vitro assessment of copper nanoparticle gel as a futuristic drug delivery agent against periodontal pathogens

Development and Characterization of Copper Nanoparticle‐Embedded pH‐responsive Polymeric Microbeads for Drug Delivery and Antibacterial Applications

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