Copper chaperone antioxidant 1: multiple roles and a potential therapeutic target

Yang, Dian; Xiao, Pengyu; Qiu, Botao; Yu, Hai-Fan; Teng, Chun‐Bo

doi:10.1007/s00109-023-02311-w

Cited by 14 publications

(11 citation statements)

References 131 publications

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“…Metallothioneins are versatile proteins that are crucial in maintaining metal homeostasis within cells, protecting against heavy metal toxicity, and contributing to cellular defense mechanisms. Their functions extend to cellular processes such as proliferation, differentiation, and protection against oxidative stress [ 37 ]. They might have potential therapeutic applications in the treatment of metal toxicity and oxidative stress-related diseases [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Exploring the Molecular Tapestry: Organ-Specific Peptide and Protein Ultrafiltrates and Their Role in Therapeutics

Slivka,

Bauer,

Younsi

et al. 2024

IJMS

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This study aims to characterize the proteome composition of organ-derived protein extracts from rabbits. Protein isolation was performed using soft homogenization and size exclusion via ultrafiltration. The proteome analysis of the ultrafiltrates was conducted using gel electrophoresis, and the mass spectrometry data were subjected to gene ontology analysis. Proteomic profiling revealed comprehensive protein profiles associated with RNA regulation, fatty acid binding, inflammatory response, oxidative stress, and metabolism. Additionally, our results demonstrate the presence of abundant small proteins, as observed in the mass spectrometry datasets. Small proteins and peptides are crucial in transcription modulation and various biological processes. The protein networks identified in the ultrafiltrates have the potential to enhance and complement biological therapeutic interventions. Data are available via ProteomeXchange with identifier PXD050039.

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Section: Discussionmentioning

confidence: 99%

Exploring the Molecular Tapestry: Organ-Specific Peptide and Protein Ultrafiltrates and Their Role in Therapeutics

Slivka,

Bauer,

Younsi

et al. 2024

IJMS

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“…ATOX1 delivers copper to ATP7A and ATP7B in the TGN [ 31 ]. Additionally, ATOX1 has been shown to function as a new type of copper-dependent transcription factor that mediates copper-induced cell proliferation [ 32 ].…”

Section: Copper Metabolismmentioning

confidence: 99%

Copper homeostasis and cuproptosis in atherosclerosis: metabolism, mechanisms and potential therapeutic strategies

Yang,

Li,

Zhou

et al. 2024

Cell Death Discov.

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Copper is an essential micronutrient that plays a pivotal role in numerous physiological processes in virtually all cell types. Nevertheless, the dysregulation of copper homeostasis, whether towards excess or deficiency, can lead to pathological alterations, such as atherosclerosis. With the advent of the concept of copper-induced cell death, termed cuproptosis, researchers have increasingly focused on the potential role of copper dyshomeostasis in atherosclerosis. In this review, we provide a broad overview of cellular and systemic copper metabolism. We then summarize the evidence linking copper dyshomeostasis to atherosclerosis and elucidate the potential mechanisms underlying atherosclerosis development in terms of both copper excess and copper deficiency. Furthermore, we discuss the evidence for and mechanisms of cuproptosis, discuss its interactions with other modes of cell death, and highlight the role of cuproptosis-related mitochondrial dysfunction in atherosclerosis. Finally, we explore the therapeutic strategy of targeting this novel form of cell death, aiming to provide some insights for the management of atherosclerosis.

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“…Copper is also essential in the body's defense against oxidative stress, primarily as a cofactor for the enzyme Superoxide Dismutase (Cu, Zn-SOD) [266]. Beyond this, copper also modulates other antioxidative systems and can influence signal transduction processes and gene expression [304][305][306][307]. Pertaining to female reproduction, copper's antioxidative properties serve to protect oocytes from oxidative stress, which is vital for their integrity and function [307,308].…”

Section: Coppermentioning

confidence: 99%

“…Beyond this, copper also modulates other antioxidative systems and can influence signal transduction processes and gene expression [304][305][306][307]. Pertaining to female reproduction, copper's antioxidative properties serve to protect oocytes from oxidative stress, which is vital for their integrity and function [307,308]. Additionally, copper supports endothelial function, crucial for optimal blood flow to the uterus and ovaries, thus positively influencing fertility [309][310][311][312][313].…”

Section: Coppermentioning

confidence: 99%

Minerals and the Menstrual Cycle: Impacts on Ovulation and Endometrial Health

Kapper,

Oppelt,

Ganhör

et al. 2024

Nutrients

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The role of minerals in female fertility, particularly in relation to the menstrual cycle, presents a complex area of study that underscores the interplay between nutrition and reproductive health. This narrative review aims to elucidate the impacts of minerals on key aspects of the reproductive system: hormonal regulation, ovarian function and ovulation, endometrial health, and oxidative stress. Despite the attention given to specific micronutrients in relation to reproductive disorders, there is a noticeable absence of a comprehensive review focusing on the impact of minerals throughout the menstrual cycle on female fertility. This narrative review aims to address this gap by examining the influence of minerals on reproductive health. Each mineral’s contribution is explored in detail to provide a clearer picture of its importance in supporting female fertility. This comprehensive analysis not only enhances our knowledge of reproductive health but also offers clinicians valuable insights into potential therapeutic strategies and the recommended intake of minerals to promote female reproductive well-being, considering the menstrual cycle. This review stands as the first to offer such a detailed examination of minerals in the context of the menstrual cycle, aiming to elevate the understanding of their critical role in female fertility and reproductive health.

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Copper chaperone antioxidant 1: multiple roles and a potential therapeutic target

Cited by 14 publications

References 131 publications

Exploring the Molecular Tapestry: Organ-Specific Peptide and Protein Ultrafiltrates and Their Role in Therapeutics

Exploring the Molecular Tapestry: Organ-Specific Peptide and Protein Ultrafiltrates and Their Role in Therapeutics

Copper homeostasis and cuproptosis in atherosclerosis: metabolism, mechanisms and potential therapeutic strategies

Minerals and the Menstrual Cycle: Impacts on Ovulation and Endometrial Health

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