Copper-Catalyzed C–H Functionalization Reactions: Efficient Synthesis of Heterocycles

Concise synthesis of pyrrolo[2,3-d]pyrimidine derivatives via the Cu-catalyzed coupling reaction

“…The pyrrolo [2,3-d ]pyrimidine derivatives were prepared in moderate yield by using Pd. Recently, Cu-catalyzed coupling reactions devoted to the efficient synthesis of heterocycles have acquired increasing attention, and displayed lower cost/toxicity of Cu sources, mild conditions, and broad substrate scope (19)(20)(21)(22)(23). Ma et al reported the first Cu/6-methylpicolinic acid catalyzed synthesis of pyrrolo [2,3-d]pyrimidine derivatives in moderate to excellent yields from substituted 5-bromopyrimidin-4-amines and alkynes (24).…”

Progress in the Synthesis and Application of Benzimidazole-Based Fluorescent Chemosensors

“…例如, Tolpygin 等 [120,121] 以及 FRET [46,108] 等, 因此根 据实际需要, 巧妙利用这些机理设计合成出高选择性、 高灵敏度的苯并咪唑类传感器仍需要努力. 同时, 随着 杂环类化合物的绿色、高效合成方法的发展 [122] , 以简洁 的合成方法得到理想的苯并咪唑基荧光传感器仍然是 一个充满活力的课题.…”

Progress in the Research of Copper Promoted C—H Functionalizations for the Synthesis of Fused Heterocycles Bearing Bridgehead Nitrogen

“…近几年来, 对于 氮桥头类杂环化合物的合成方法学研究也取得很好的 进展. 为了更好地了解这方面的新动态新进展, 本文拟 对 2010 年以来的铜促 C-H 官能团化合成氮桥头稠杂 环的工作作一综述 [10] .…”