Copeptin, B-type natriuretic peptide and cystatin C are associated with incident symptomatic PAD

Fatemi, Shahab; Acosta, Stefan; Gottsäter, Anders; Melander, Olle; Engström, Gunnar; Dakhel, Ardwan; Zarrouk, Moncef

doi:10.1080/1354750x.2019.1631886

Cited by 21 publications

(16 citation statements)

References 39 publications

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“…Biomarkers analyzed in this material have previously been related to incident symptomatic arterial disease in the lower extremities. 54,55 Even though lower extremity arterial disease and carotid artery disease to some extent share similar risk factors, 56 these two arterial territories are quite different in several aspects, such as prevalence of atherosclerosis 57 and regarding hemodynamic properties. 58 In conclusion, levels of biomarkers such as NT pro-BNP and MR-proADM can be used as independent predictors for clinically detected carotid artery stenosis during longterm follow-up of subjects from the general population.…”

Section: Characteristicmentioning

confidence: 99%

Pro B-type Natriuretic Peptide and Midregional Proadrenomedullin are Associated with Incident Carotid Stenosis During Long Term Follow-up

Fatemi

Acosta

Zarrouk

et al. 2021

Journal of Stroke and Cerebrovascular Diseases

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Background: Plasma biomarkers may be useful to detect healthy individuals at increased risk for atherosclerotic manifestations, such as carotid artery stenosis. The aim of this longitudinal cohort study was to evaluate new biomarkers in relation to C-reactive protein and conventional risk factors for carotid artery stenosis during long term follow-up Methods: The following markers were measured in 5550 middle-aged subjects: C-reactive protein, lipoprotein-associated phospholipase A2, proneurotensin, midregional pro-adrenomedullin, midregional pro-atrial natriuretic peptide, N-terminal pro B-type natriuretic peptide, copeptin, and cystatin C. Subjects with prevalent carotid artery stenosis were excluded. Subjects were followed in national patient registers for 23.4 (interquartile range 19.5À24.3) years regarding incident carotid artery stenosis, both operated and non-operated. Results: When including conventional risk markers in Cox regression, N-terminal pro B-type natriuretic peptide (Hazard ratio 1.36; 95% confidence interval 1.12À1.65; p = 0.002) was independently associated with incident carotid artery stenosis, whereas there were trends for C-reactive protein (HR 1.20; 95% confidence interval 0.98À1.48; p = 0.071), and midregional pro-adrenomedullin (Hazard ratio 1.21; 95% confidence interval 0.99À1.47; p = 0.061). Midregional pro-adrenomedullin (Hazard ratio 1.30; 95% confidence interval 1.03À1.65; p = 0.029) was independently associated with incident surgery for carotid artery stenosis, whereas there was a trend for N-terminal pro B-type natriuretic peptide (Hazard ratio 1.31; 95% confidence interval 1.00À1.72; p = 0.052). Conclusions: N-terminal pro B-type natriuretic peptide and midregional pro-adrenomedullin can be used as predictors for clinically detected carotid artery stenosis during long-term follow-up of healthy subjects.

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Section: Characteristicmentioning

confidence: 99%

Pro B-type Natriuretic Peptide and Midregional Proadrenomedullin are Associated with Incident Carotid Stenosis During Long Term Follow-up

Fatemi

Acosta

Zarrouk

et al. 2021

Journal of Stroke and Cerebrovascular Diseases

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“…Given its documented advantages in identifying subclinical kidney disease, cystatin C has constantly been used as a marker associated with cardiovascular events [29,30,56,57]. Additionally, several recent studies have noticed the relationship between serum cystatin C levels and the presence of atherosclerotic plaques [31,32,58]. The proposed mechanism involves an extensive proteolytic activity of the arterial wall extracellular matrix and the compensatory, enhanced activity of cystatin C as a protease enzyme inhibitor [59].…”

Section: Discussionmentioning

confidence: 99%

“…Cystatin C, a non-glycosylated protein affiliated with cystatin protease inhibitors, is used as either a single marker or as part of a multimarker panel strategy for the assessment of cardiovascular and renal interactions [29,30]. Moreover, high cystatin C levels independently correlate with early atherosclerotic plaque development and progression, even though current studies have primarily focused on carotid and coronary involvement [31,32].…”

Section: Introductionmentioning

confidence: 99%

Biomarker Utility for Peripheral Artery Disease Diagnosis in Real Clinical Practice: A Prospective Study

et al. 2020

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Peripheral arterial disease (PAD) is a common manifestation of generalized atherosclerosis, which affects more than 200 million patients worldwide. Currently, there is no ideal biomarker for PAD risk stratification and diagnosis. The goal of this research was to investigate the levels of inflammation biomarkers and cystatin C and to explore their utility for the diagnosis of PAD. The study included 296 participants, distributed in two groups: 216 patients diagnosed with PAD and 80 patients without PAD as controls. All studied biomarker levels (C-reactive protein, CRP; fibrinogen; erythrocyte sedimentation rate, ESR; neopterin; beta 2-microglobulin, B2-MG; and cystatin C) were significantly higher in the PAD group and indirectly correlated with the ankle–brachial index (ABI). The final logistic regression model included an association of neopterin, fibrinogen, and cystatin C as the most efficient markers for the prediction of PAD diagnosis. When comparing the area under the curve (AUC) for all biomarkers, the value for neopterin was significantly higher than those of all the other analyzed biomarkers. In agreement with previous studies, this research shows that markers such as fibrinogen, CRP, ESR, B2-MG, and cystatin C have significant value for the diagnosis of PAD, and also clearly underlines the accuracy of neopterin as a leading biomarker in PAD prediction.

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“…14 Swedish national registries in records at our hospital has documented a validity of 98%. 15 The study was approved by the previous regional research committee in Lund, Sweden, 2014/643. The investigation conforms to the principles outlined in the Declaration of Helsinki.…”

Section: Follow-up and End Point Retrievalmentioning

confidence: 99%

Vasoactive Biomarkers Associated With Long-Term Incidence of Symptomatic Peripheral Arterial Disease and Mortality

et al. 2021

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We evaluated if plasma biomarkers can predict incident peripheral arterial disease (PAD) and mortality in a longitudinal cohort study. Men (n = 3618) and women (n = 1542) were included in the Malmö Preventive Project and underwent analysis of: C-terminal endothelin-1 (CT-proET-1), N-Terminal prosomatostatin (NT-proSST), midregional proatrial natriuretic peptide (MR-proANP), procalcitonin (PCT), and copeptin. Participants were followed up for incident PAD and mortality until December 31, 2016. Median follow-up was 11.2 years (interquartile range 9.4-12.2). Cumulative incidence of PAD was 4.3% (221/5160), 4.5% in men (164/3618) and 3.7% in women (57/1542; P = .174). In an adjusted Cox proportional hazards regression model, higher CT-proET-1 (hazard ratio [HR] 1.8; 95% confidence interval [CI] 1.4-2.3), NT-proSST (HR 1.5; 95% CI 1.2-2.0), and MR-proANP (HR 1.7; 95% CI 1.3-2.3) were independently associated with incident PAD, and higher CT-proET-1 (HR 1.3; 95% CI 1.2-1.5), NT-proSST (HR 1.2; 95% CI 1.1-1.3), MR-proANP (HR 1.4; 95% CI 1.3-1.6), PCT (HR 1.1; 95% CI 1.0-1.2), and copeptin (HR 1.2; 95% CI 1.1-1.4) were independently associated with mortality. Increased levels of CT-proET-1, NT-proSST, and MR-proANP were independently associated with incident PAD, whereas all the vasoactive biomarkers were independently associated with mortality during follow-up.

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Copeptin, B-type natriuretic peptide and cystatin C are associated with incident symptomatic PAD

Cited by 21 publications

References 39 publications

Pro B-type Natriuretic Peptide and Midregional Proadrenomedullin are Associated with Incident Carotid Stenosis During Long Term Follow-up

Pro B-type Natriuretic Peptide and Midregional Proadrenomedullin are Associated with Incident Carotid Stenosis During Long Term Follow-up

Biomarker Utility for Peripheral Artery Disease Diagnosis in Real Clinical Practice: A Prospective Study

Vasoactive Biomarkers Associated With Long-Term Incidence of Symptomatic Peripheral Arterial Disease and Mortality

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