Copeptin as a prognostic factor for major adverse cardiovascular events in patients with coronary artery disease

Haehling, Stephan von; Papassotiriou, Jana; Morgenthaler, Nils G.; Hartmann, Oliver; Doehner, Wolfram; Stellos, Konstantinos; Wurster, Thomas; Schuster, Andreas; Nagel, Eike; Gawaz, Meinrad; Bigalke, Boris

doi:10.1016/j.ijcard.2011.12.105

Cited by 51 publications

(42 citation statements)

References 43 publications

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“…In sepsis, for example, elevated CRP correlates with disease severity [13,14]. Copeptin is known to be elevated in patients with sepsis [15] and myocardial damage [16,17]. In the malaria patients, significantly elevated levels but no association regarding the severity of malaria were found.…”

Section: Discussionmentioning

confidence: 99%

Clinical relevance of different biomarkers in imported plasmodium falciparum malaria in adults: a case control study

Stauga

Hahn

Brattig

et al. 2013

Malar J

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BackgroundFor rapid initiation of anti-malarial treatment and prevention of complications, early diagnosis and risk stratification is important in patients with Plasmodium falciparum malaria. Routine laboratory values do not correlate well with disease severity. The aim of this study was to determine the diagnostic and prognostic value of several biomarkers related to inflammation; endothelial and cardiac dysfunction; coagulation, and haemolysis in imported P. falciparum malaria.MethodsIn a prospective case-control study, 79 adult travellers with both uncomplicated and complicated P. falciparum malaria were included between 2007 and 2011. Forty-one healthy subjects were included as controls. Blood samples were obtained within 24 hours after first consultation to assess routine laboratory values as well as markers related to inflammation (PAPP-A, copeptin, CRP), endothelial activation (MPO, elastase-2, endothelin-1, sICAM-1, sVCAM-1), cardiac function (NT-proBNP, MR-proANP), coagulation (fibrinogen, D-dimers, platelet count), and haemolysis (LDH). Prognostic performance was assessed using the receiver operating characteristic curve (area under the curve = AUROC).ResultsTwelve (15.2%) patients had severe P. falciparum malaria. In the patient group, significant thrombocytopaenia was found, all other markers but PAPP-A were significantly elevated. Diagnostic performance was best for CRP with an AUROC of 1.00, followed by MPO (0.99), D-dimers (0.98), elastase-2 (0.98), and sICAM-1 (0.98). Biomarker levels did not correlate well with disease severity.ConclusionThe combination of travel history, fever prior to blood sampling, and CRP serum levels above or below 10.8 mg/l upon hospital admission, best discriminated between malaria patients and control persons. None of the biomarkers studied predicted the presence or the development of malaria complications, neither at the time of admission, nor during hospitalization.

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Section: Discussionmentioning

confidence: 99%

Clinical relevance of different biomarkers in imported plasmodium falciparum malaria in adults: a case control study

Stauga

Hahn

Brattig

et al. 2013

Malar J

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“…MR-proANP and C-terminal portion of pro-vasopressin (copeptin) are associated with increased all-cause mortality at 3 months (cut-off value; 236 pmol/L, 21.6 pmol/L, respectively). Interestingly, the positive predictive value copeptin alone was found superior to that of cTnI 65,66…”

Section: Acute Cardiac Conditionsmentioning

confidence: 98%

Perspectives on the Value of Biomarkers in Acute Cardiac Care and Implications for Strategic Management

et al. 2013

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Biomarkers in acute cardiac care are gaining increasing interest given their clinical benefits. This study is a review of the major conditions in acute cardiac care, with a focus on biomarkers for diagnostic and prognostic assessment. Through a PubMed search, 110 relevant articles were selected. The most commonly used cardiac biomarkers (cardiac troponin, natriuretic peptides, and C-reactive protein) are presented first, followed by a description of variable acute cardiac conditions with their relevant biomarkers. In addition to the conventional use of natriuretic peptides, cardiac troponin, and C-reactive protein, other biomarkers are outlined in variable critical conditions that may be related to acute cardiac illness. These include ST2 and chromogranin A in acute dyspnea and acute heart failure, matrix metalloproteinase in acute chest pain, heart-type fatty acid binding protein in acute coronary syndrome, CD40 ligand and interleukin-6 in acute myocardial infarction, blood ammonia and lactate in cardiac arrest, as well as tumor necrosis factor-alpha in atrial fibrillation. Endothelial dysfunction, oxidative stress and inflammation are involved in the physiopathology of most cardiac diseases, whether acute or chronic. In summary, natriuretic peptides, cardiac troponin, C-reactive protein are currently the most relevant biomarkers in acute cardiac care. Point-of-care testing and multi-markers use are essential for prompt diagnostic approach and tailored strategic management.

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“…In a large cath lab cohort (2,700 patients; SA group n = 1, 384) [107], copeptin was evaluated for its prognostic value regarding morbidity and mortality. Interestingly, patients with a family history of CAD had significantly higher copeptin baseline levels ( P = 0.0141).…”

Section: Biomarkers and Stable Anginamentioning

confidence: 99%

Clinical Usefulness of Novel Serum and Imaging Biomarkers in Risk Stratification of Patients with Stable Angina

et al. 2014

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Inflammatory mediators appear to be the most intriguing yet confusing subject, regarding the management of patients with acute coronary syndromes (ACS). The current inflammatory concept of atherosclerotic coronary artery disease (CAD) led many investigators to concentrate on systemic markers of inflammation, as well as imaging techniques, which may be helpful in risk stratification and prognosis assessment for cardiovascular events. In this review, we try to depict many of the recently studied markers regarding stable angina (SA), their clinical usefulness, and possible future applications in the field.

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Copeptin as a prognostic factor for major adverse cardiovascular events in patients with coronary artery disease

Cited by 51 publications

References 43 publications

Clinical relevance of different biomarkers in imported plasmodium falciparum malaria in adults: a case control study

Clinical relevance of different biomarkers in imported plasmodium falciparum malaria in adults: a case control study

Perspectives on the Value of Biomarkers in Acute Cardiac Care and Implications for Strategic Management

Clinical Usefulness of Novel Serum and Imaging Biomarkers in Risk Stratification of Patients with Stable Angina

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