Copeptin and Biomarkers of Inflammation in Patients With Different Types of Acute Coronary Syndrome

Сукманова, И. А.; Tanana, O. S.; Пономаренко, И. В.; Косоухов, А. П.

doi:10.17802/2306-1278-2017-6-4-44-49

Cited by 3 publications

(1 citation statement)

References 5 publications

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“…Интерлейкин-18 -провоспалительный цитокин с молекулярной массой 18 кДа, является также медиатором ишемического повреждения миокарда, мозга и почек. Значительное возрастание его содержания в ткани почек возникает именно при ишемическом поражении [21].…”

Section: особенности лабораторных показателей кин биомаркеры почечноunclassified

Contrast-induced nephropathy in patients with acute coronary syndrome: clinical significance, diagnosis, prophylaxis

Демчук

Сукманова

Пономаренко

et al. 2020

Cardiovasc Ther Prev

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1КГБУЗ "Алтайский краевой кардиологический диспансер". Барнаул; 2 ФГБОУ ВО "Алтайский государственный медицинский университет" Минздрава России. Барнаул, Россия В современной медицинской практике контраст-индуцированная нефропатия (КИН) является актуальной проблемой у пациентов с острым коронарным синдромом, подвергшимся чрескожным вмешательствам. Она имеет серьезные прогностические последствия, увеличивает число сердечно-сосудистых осложнений и срок пребывания в стационаре. Несмотря на использование современных рентген-контрастных препаратов частота возникновения КИН может увеличиваться у определенной когорты больных до 50%. Факторы риска развития КИН могут быть связаны как с пациентом, так и непосредственно с лучевой процедурой. Диагностика этого осложнения основывается в основном на определении креатинина до и после процедуры, но в настоящее время имеет место определение более современных биомеркеров почечного повреждения, которые позволяют в максимально короткие сроки диагностировать развитие острого почечного повреждения. Огромную роль играет не только лечение, но и профилактика развития КИН, которая заключается в своевременном выявлении пациентов с высоким риском ее развития. В представленной работе представлены основные моменты патогенеза, методы диагностики КИН, а также способы ее профилактики и лечения у пациентов с острым коронарным синдромом.Ключевые слова: контраст-индуцированная нефропатия, острый коронарный синдром, рентген-контрастные препараты, биомаркеры, острое почечное повреждение.Отношения и деятельность: нет.

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Section: особенности лабораторных показателей кин биомаркеры почечноunclassified

Contrast-induced nephropathy in patients with acute coronary syndrome: clinical significance, diagnosis, prophylaxis

Демчук

Сукманова

Пономаренко

et al. 2020

Cardiovasc Ther Prev

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Acute kidney injury in patients with myocardial infarction and percutaneous coronary interventions: laboratory markers and the influence on the frequency of recurrent cardiovascular events

Демчук

Sukmanova

2023

Kompleks. probl. serdečno-sosud. zabol.

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Highlights. Biomarkers of acute kidney injury and their effect on the frequency of recurrent coronary events in patients with myocardial infarction after percutaneous coronary interventions.Aim. To study biomarkers of acute kidney injury (AKI) and prognosis, as well as the frequency of recurrent cardiovascular events in patients with myocardial infarction and percutaneous coronary interventions.Methods. 166 patients with myocardial infarction and performed percutaneous coronary interventions were studied, divided into 2 groups: with acute kidney injury (n = 91) and without it (n = 50), the control group consisted of 25 people. All patients underwent standard general clinical and biochemical blood tests to assess the level of C-reactive protein, markers of myocardial necrosis, natriuretic peptide (NTproBNP), microalbuminuria (MAU). In both groups, the glomerular filtration rate (GFR) was calculated using the CKD-EPI formula. An increase in serum creatinine by 26.5 mmol/L or more during the first 3 days from the value at admission was the reason for the study of the level of Kidney Injury Molecule-1 (KIM-1) and interleukin 18 (IL-18) in urine on the 3rd and 14th days from hospitalization. All patients underwent coronary angiography and stenting of the infarct-dependent artery. 6 months and 1 year after discharge for this acute coronary event, repeated examinations of patients were performed to assess the frequency of repeated cardiovascular events and kidney function.Results. It was revealed that the creatinine level in the examined patients did not differ statistically significantly at admission, but there was a decrease in the filtration function of the kidneys in patients with AKI. On the third day of hospitalization, there was an increase in creatinine levels in the first group of patients with a decrease in GFR. The level of the KIM-1 and IL-18 molecules on the 3rd day of hospitalization in the first group was higher than the corresponding indicator of the comparison group. Also, patients with AKI showed a significant increase in the level of NTproBNP and MAU in the early period of kidney damage. When studying correlations, it was revealed that the level of MAU in the group with AKI is interrelated with the indicator of C-reactive protein and creatinine on the 3rd day of hospitalization. Also, a positive statistically significant correlation was found between the level of the KIM-1 molecule, IL-18, creatinine level on the 3rd day of hospitalization, NTproBNP and the level of MAU. During the follow-up of patients 6 months and a year after discharge, unstable angina pectoris, myocardial infarction, as well as progression of chronic heart failure were more often detected in the group with AKI. A persistent decrease in kidney function after a year was observed in most patients of the first group.Conclusion. The data obtained indicate the influence of acute kidney injury on the progression of renal dysfunction and the frequency of recurrent cardiovascular events, which is confirmed by the obtained associative relationships of the level of the KIM-1 molecule, creatinine and GFR with the prognosis of cardiovascular disease.

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Overview of metabolomic markers used for diagnosing cardiovascular diseases

Astafyeva

Zharkov

Ясенявская

et al. 2022

Sibirskij nauchnyj medicinskij zhurnal

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At present, metabolomics is an intensively developing approach to the specific diagnosis of cardiovascular diseases. Metabolic analysis allows the study of complete metabolomic profiles and their deviations resulting from changes, for example, gene and RNA expression, protein activity, or environmental factors. Analysis of the metabolomic blood profile helps in solving a large number of scientific and clinical problems, one of which is the search for markers of diseases, in particular, cardiovascular diseases (CVD). Aim of the study was to investigate metabolomic markers used for the diagnosis of cardiovascular diseases on the basis of literature data. Material and methods. The literature data was analyzed for key words: cardiovascular diseases, metabolomics, metabolic profile, metabolomic markers in da- tabases PubMed, Scopus, Web of Science, CyberLeninka, PatentDB, Science Direct Open Access, eLibrary. Results. Analysis of literature data and patent search confirms the high importance of metabolomic markers in the diagnosis of CVD. In the patent literature, BNP/NT-proBNP is most common used as a metabolic marker of CVD (11.27 %). The use of CRP (8.99 %) and troponin (8.49 %) is also common. PICP (0.02 %), sVCAM-1 (0.09 %), stimulating growth factor ST-2 (0.12 %) and thrombomodulin (0.12 %) as metabolic markers of CVD. Conclusions. Against the backdrop of analytical methods, metabolomics is the most important diagnostic area. At the same time, it should be noted that by combining the results of the analysis of metabolic studies with others, for example, genomic and proteomic, one can get a complete picture of the pathogenesis of diseases, assess the risk of complications, and also determine the effectiveness of the treatment.

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Copeptin and Biomarkers of Inflammation in Patients With Different Types of Acute Coronary Syndrome

Cited by 3 publications

References 5 publications

Contrast-induced nephropathy in patients with acute coronary syndrome: clinical significance, diagnosis, prophylaxis

Contrast-induced nephropathy in patients with acute coronary syndrome: clinical significance, diagnosis, prophylaxis

Acute kidney injury in patients with myocardial infarction and percutaneous coronary interventions: laboratory markers and the influence on the frequency of recurrent cardiovascular events

Overview of metabolomic markers used for diagnosing cardiovascular diseases

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