Copeptin: a blood test marker of syncope

Lagi, Alfonso; Cuomo, Alessandra; Veneziani, Francesca; Cencetti, Simone

doi:10.1111/ijcp.12123

Cited by 12 publications

(13 citation statements)

References 21 publications

(31 reference statements)

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“…Lagi et al showed that almost 30% of older patients without memory deficit had difficulties recalling a minor fall after 3 months 12. Considering that nearly 50% of cases are not witnessed, markers that could exclude or confirm orthostatic instability and syncope would be of great value.…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular biomarkers predict fragility fractures in older adults

Johansson

Ricci

et al. 2018

Heart

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ObjectiveTo assess the role of four biomarkers of neuroendocrine activation and endothelial dysfunction in the longitudinal prediction of fragility fractures.MethodsWe analysed a population-based prospective cohort of 5415 community-dwelling individuals (mean age, 68.9±6.2 years) enrolled in the Malmö Preventive Project followed during 8.1±2.9 years, and investigated the longitudinal association between C-terminal pro-arginine vasopressin (CT-proAVP), C-terminal endothelin-1 precursor fragment (CT-proET-1), the mid-regional fragments of pro-adrenomedullin (MR-proADM) and pro-atrial natriuretic peptide (MR-proANP), and incident vertebral, pelvic and extremity fractures.ResultsOverall, 1030 (19.0%) individuals suffered vertebral, pelvic or extremity fracture. They were older (70.7±5.8 vs 68.4±6.3 years), more likely women (46.9% vs 26.3%), had lower body mass index and diastolic blood pressure, were more often on antihypertensive treatment (44.1% vs 38.4%) and had more frequently history of fracture (16.3% vs 8.1%). Higher levels of MR-proADM (adjusted HR (aHR) per 1 SD: 1.51, 95% CI 1.01 to 2.28, p<0.001) and MR-proANP (aHR: 1.23, 95% CI 1.05 to 1.45, p<0.001) were independently associated with increased risk of any fracture. The fracture risk increased linearly across MR-proANP quartiles. Individuals who were in the top quartile of all four biomarkers had a significant higher risk of fracture at any site (aHR: 2.32, 95% CI 1.86 to 2.91), vertebral fracture (aHR: 3.16, 95% CI 1.97 to 5.07) and femoral fracture (aHR: 2.35, 95% CI 1.64 to 3.36).ConclusionsElevated levels of MR-proADM and MR-proANP independently predict fragility fractures in older adults. In subjects with top quartile levels of all four biomarkers there is a twofold to threefold increase in risk of vertebral and femoral fractures.

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Section: Discussionmentioning

confidence: 99%

Cardiovascular biomarkers predict fragility fractures in older adults

Johansson

Ricci

et al. 2018

Heart

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“…Lagi et al . recently reported that the levels of stable vasopressin synthesis by‐product copeptin are above normal in subjects with syncope, including vasovagal syncope. However, the diagnostic criteria were imprecise and no control population was reported.…”

Section: Discussionmentioning

confidence: 99%

“…It may be that our results differ from those of Lagi et al . because of differences in patient population or local differences in technique.…”

Section: Discussionmentioning

confidence: 99%

Assessment of endothelin and copeptin as biomarkers for vasovagal syncope

Rash

McRae

Fatehi

et al. 2016

Eur J Clin Investigation

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“…[10][11][12] In particular, a recent report explored the associations between specific diagnoses of syncope and resting levels of circulating biomarkers: C-terminal pro-arginine vasopressin (CTproAVP), C-terminal endothelin-1 precursor fragment (CTproET-1), and midregional fragments of pro-atrial natriuretic peptide (MR-proANP) and pro-adrenomedullin (MRproADM). 7 A principal observation was the association of high concentration CT-proET-1 with OH.…”

Section: Discussionmentioning

confidence: 99%