Copaifera multijuga oleoresin and its constituent diterpene (−)-copalic acid: Genotoxicity and chemoprevention study

Alves, Jacqueline Morais; Senedese, Juliana Marques; Leandro, Luís Fernando; Castro, Pâmela Tinti de; Pereira, Daiane E.; Carneiro, Luiza J.; Ambrósio, Sérgio Ricardo; Bastos, Jairo Kenupp; Tavares, Denise Crispim

doi:10.1016/j.mrgentox.2017.05.001

Cited by 13 publications

(10 citation statements)

References 47 publications

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“…The identification of the plant material was undertaken by Silvana Tavares Rodrigues at the Herbarium of the Brazilian Agricultural Research Corporation (EMBRAPA) in Belém, Pará, Brazil, where a voucher specimen was deposited under the number NID: 62/2013. Isolation of (−)-copalic acid from C. multijuga oleoresin and its identification The chromatographic process to isolate CA was previously reported by Alves et al (2017). Briefly, 100 g of crude oleoresin were fractionated on Vacuum Liquid Chromatography using a gradient elution with hexanes and ethyl acetate.…”

Section: Collection Of Oleoresin Isolation and Identification Of (−)mentioning

confidence: 99%

Antigenotoxicity properties of Copaifera multijuga oleoresin and its chemical marker, the diterpene (−)-copalic acid

Alves

Leandro

Senedese

et al. 2017

Journal of Toxicology and Environmental Health, Part A

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2-AA, 2-anthramine; 2-AF, 2-aminofluorene; AFB, aflatoxin B; B[a]P, benzo[a]pyrene; BOD, biological oxygen demand; BPDE, benzo[a]pyrene-7,8-diol-9,10-epoxide; CA, (-)-copalic acid; CMO, oleoresin of Copaifera multijuga, DMEM, Dulbecco`s Modified Eagles`s Medium; DMSO, dimethylsulfoxide; EMBRAPA, Brazilian agricultural research corporation; GC-MS, gas chromatography-mass spectrometry; HAM-F10, nutrient mixture F-10 Ham; HPLC, high performance liquid chromatography; LC-MS, liquid chromatography-mass spectrometry; MI, mutagenic index; MMC, mitomycin C; MMS, methyl methanesulfonate; MN, micronucleus; MNPCE, micronucleated polychromatic erythrocyte; NCE, normochromatic erythrocyte; NDI, nuclear division index; NMR, nuclear magnetic resonance; NPD, 4-nitro-o-phenylenediamine; PBS, phosphate-buffered saline; PCE, polychromatic erythrocyte; SA, sodium azide; V79, Chinese hamster lung fibroblast.

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Section: Collection Of Oleoresin Isolation and Identification Of (−)mentioning

confidence: 99%

Antigenotoxicity properties of Copaifera multijuga oleoresin and its chemical marker, the diterpene (−)-copalic acid

Alves

Leandro

Senedese

et al. 2017

Journal of Toxicology and Environmental Health, Part A

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“…Furtado et al [28] showed no genotoxic effects in both in vitro and in vivo micronucleus assays using different concentrations of C. multijuga leaf extracts and oleoresin. No genotoxic effects were also observed by Alves et al [29] in their micronucleus tests with C. multijuga oleoresin.…”

Section: /8mentioning

confidence: 55%

Natural killer activity of the spleen cells of Ehrlich tumor-bearing mice treated with Copaifera multijuga extract

Rodrigues

Albiero

Nery

et al. 2019

Sci Med

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AIMS: Copaifera multijuga Hayne oleoresin is commonly used in traditional medicine owing to its anti-inflammatory, antiseptic, antitumor, and antibacterial properties. However, little is known about the effect of the compounds from the bark of this plant. In this study, the immunomodulatory effect of the ethanolic extract of C. multijuga bark via natural killer activity of non-adherent spleen cells of Ehrlich tumor-bearing mice was evaluated.METHODS: Male Swiss mice were inoculated subcutaneously with 1×106 Ehrlich tumor cells (Ehrlich and Ehrlich/C. multijuga group) or phosphate buffered saline solution (control group and C. multijuga group) and treated orally daily with C. multijuga extract (200 mg kg-1, 0.1 mL per mouse, for the Ehrlich/C. multijuga and C. multijuga groups) or phosphate buffered saline solution (control group and Ehrlich group). The four experimental groups consisted in eight mice each and were organized in two sets, one treated for seven days and another treated for 14 days, totalizing 64 mice throughout the experiment. Twenty-four hours after the last oral administration, the mice were euthanized and the spleen tissue was isolated to prepare a non-adherent spleen cell suspension and to evaluate natural killer activity. Data are presented as the cell lysis percentage of Yac.1 target cells by non-adherent spleen cells.RESULTS: Treatment for seven days increased natural killer activity in the Ehrlich/C. multijuga group (21.20±8.89, p<0.05) compared to the control group (3.14±2.71, p<0.05); however, this effect was not maintained in the groups treated for 14 days (Control: 6.02±6.98, Ehrlich: 4.82±7.72, C. multijuga: 2.07±2.10, Ehrlich/C. multijuga: 2.01±1.63, p>0.05).CONCLUSIONS: Treatment for seven days with an ethanolic extract of C. multijuga bark enhanced the natural killer activity of non-adherent spleen cells from Ehrlich tumor-bearing mice.

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“…To date, there are few reports in the literature related to the use of C.O as P.E (Quiñones et al ., 2017, epub ahead of print). However, studies on commercial product safety reveal that this substance is not genotoxic or mutagenic and has shown to be safe after topical application …”

Section: Discussionmentioning

confidence: 99%

“…To date, there are few reports in the literature related to the use of C.O as P.E (Quiñones et al, 2017, epub ahead of print). However, studies on commercial product safety reveal that this substance is not genotoxic or mutagenic [55,63] and has shown to be safe after topical application. [64] Altogether, the results obtained with formulation F4, composed of 2% Cxb and 25% C.O in PEG-400/PG, indicate that it is suitable for the treatment of superficial inflammation of the skin (including skin cancer induced by UVB) and inflammation process from rheumatoid arthritis.…”

Section: Discussionmentioning

confidence: 99%

Copaiba oil enhances in vitro/in vivo cutaneous permeability and in vivo anti-inflammatory effect of celecoxib

Quiñones

Hossy

Pádua

et al. 2018

Journal of Pharmacy and Pharmacology

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Copaifera multijuga oleoresin and its constituent diterpene (−)-copalic acid: Genotoxicity and chemoprevention study

Cited by 13 publications

References 47 publications

Antigenotoxicity properties of Copaifera multijuga oleoresin and its chemical marker, the diterpene (−)-copalic acid

Antigenotoxicity properties of Copaifera multijuga oleoresin and its chemical marker, the diterpene (−)-copalic acid

Natural killer activity of the spleen cells of Ehrlich tumor-bearing mice treated with Copaifera multijuga extract

Copaiba oil enhances in vitro/in vivo cutaneous permeability and in vivo anti-inflammatory effect of celecoxib

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