Copaiba oil-resin (Copaifera reticulata Ducke) modulates the inflammation in a model of injury to rats’ tongues

Abstract

BackgroundThe regeneration of integrity and tissue homeostasis after injury is a fundamental property and involves complex biological processes fully dynamic and interconnected. Although there are medications prescribed to accelerate the process of wound healing by reducing the exaggerated inflammatory response, comes the need to search for different compounds of Amazonian biodiversity that can contribute to the acceleration of the healing process. Among these products, the copaiba oil-resin is one of the most prominent feature in this scenario, as they have been reported its medicinal properties.MethodsAiming to evaluate the anti-inflammatory and healing effect of copaiba oil-resin (Copaifera reticulata Ducke) in transfixing injury of rats’ tongues first proceeded up the copaiba oil-resin oral toxicity test in 5 male mice to stipulate the therapeutic dose which was established at 200 mg/kg/day. Then it was induced transfixing injury in a total of 15 Wistar rats. The animals were randomly divided into three groups based on the treatment: control group, dexamethasone group and copaiba oil-resin group. After 7 days of treatment, histological slides stained with hematoxylin and eosin was prepared. Immunohistochemistry for CD68 (macrophage marker) was performed and analyzed by the cell counter Image J.ResultsThe acute toxicity test showed that the oil-resin copal has low toxicity. Furthermore, copaiba oil-resin therapy modulates the inflammatory response by decreasing the chronic inflammatory infiltrate, edema and specifically the number of macrophages.ConclusionsThe results indicate the potential of the Amazon region and showed up relevant because therapy with this extract modulates the inflammatory process.

Meta-analysis on Copaiba Oil: Its Functions in Metabolism and Its Properties as an Anti-inflammatory Agent

“…One derivative of these plants is copaiba oil found in Copaifera reticulata Ducke, a natural product of the Amazon's biodi-versity. 1 It has been used for more than 390 years as an antiinflammatory, antimicrobial, and antifungal agent, and to prevent various types of cancer. 2,3 type of tree.…”

“…Previous studies have claimed that copaiba oil, extracted from the copaibeira, could be found in more than 60 species cataloged worldwide. 1 However, in later studies it has been reported that there are currently 72 species of copaibeiras in the world, all exclusively in Brazilian soil. 3 The anti-inflammatory and antimicrobial properties of copaiba oil have been drawing the attention of the scientific community as alternatives in the treatment for illnesses associated with inflammatory and infectious processes within the body.…”

Antibacterial Activity of Rosmarinus officinalis, Zingiber officinale, Citrus aurantium bergamia, and Copaifera officinalis Alone and in Combination with Calcium Hydroxide against Enterococcus faecalis

“…e essential oils used in the research came from different regions, such as Morocco, China, Italy, and Brazil. All essential oils have been shown to possess antimicrobial, antiinflammatory, antifungal, analgesic, antioxidant, and healing properties [8,12,13]. e MIC and MBC obtained for the 13 experimental groups are shown in Table 3 and in Figure 1.…”

“…Several phytotherapeutic compounds have been studied in pure form or combined with calcium hydroxide in order to potentiate the effects of the latter, improving the prognosis of endodontic treatment [7][8][9][10][11]. Plant extracts such as the essential oils of rosemary (Rosmarinus officinalis L.), ginger (Zingiber officinale), bergamot (Citrus aurantium bergamia), and copaiba (Copaifera officinalis) have been shown to possess antimicrobial, anti-inflammatory, antifungal, analgesic, antioxidant, and healing properties [8,12,13].…”

Safety and Effectiveness of Copaiba Oleoresin (C. reticulata Ducke) on Inflammation and Tissue Repair of Oral Wounds in Rats

“…Previous studies revealed the effectiveness of copaiba oleoresin in modulating inflammatory infiltrate in oral lesions compared to corticoid-treated [14,18]. However, the effect on reepithelization and the safety of the dosage administrated concerning renal and liver functions, have not been assessed.…”