Coordination polymer nanoparticles in medicine

Novio, Fernando; Simmchen, Juliane; Vázquez-Mera, Nuria Alexandra; Amorín-Ferré, Laura; Ruiz‐Molina, Daniel

doi:10.1016/j.ccr.2013.04.022

Cited by 166 publications

(82 citation statements)

References 79 publications

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“…These NPs have the combined advantages of both nanomaterial and organic complexes, eg, biodegradability, compositional diversity, and ease of preparation. 30 As such, it was important to investigate whether BSA were able to tune the synthesis of coordination polymer NPs by the formation of a BSA-transition metal ion complex. In this process, the transition-metal ions would play a similar role as inorganic NPs.…”

Section: +mentioning

confidence: 99%

BSA-assisted synthesis of ultrasmall gallic acid–Fe(III) coordination polymer nanoparticles for cancer theranostics

Mu¹,

Yan²,

Tian³

et al. 2017

IJN

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Protein-related nanotheranostic agents hold great promise as tools to serve many clinical applications. Proteins such as BSA are used to regulate the synthesis of nondegradable inorganic nanoparticles (NPs). To fully employ the potential of such proteins, a new type of biosafe nanotheranostic agent must be designed to optimize BSA as a biomineralization agent. Here, a straightforward BSA-assisted biomineralization method was developed to prepare gallic acid (GA)–Fe(III) coordination polymer NPs. BSA-coated GA-Fe (GA-Fe@BSA) NPs were ultrasmall (3.5 nm) and showed good biocompatibility, a lower r 2 : r 1 ratio (1.06), and strong absorption in the visible near-infrared region. T 1 -weighted magnetic resonance imaging of tumor-bearing mice before and after intratumoral injection with GA-Fe@BSA NPs definitively demonstrated positive change. In a subsequent in vivo study, antitumor activity was precipitated by intratumoral injection of GA-Fe@BSA NPs combined with laser treatment, suggesting excellent outcomes with this treatment method. These results describe a successful protocol in which BSA regulated the synthesis of benign organic polymer NPs. GA-Fe@BSA NPs have the potential to be ideal agents to be used in clinical theranostic nanoplatforms.

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Section: +mentioning

confidence: 99%

BSA-assisted synthesis of ultrasmall gallic acid–Fe(III) coordination polymer nanoparticles for cancer theranostics

Mu¹,

Yan²,

Tian³

et al. 2017

IJN

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“…[4][5][6] Among the large number of particles proposed as potential drug delivery and/or bioimaging systems, nanometric porous metal-organic frameworks (nanoMOFs) have recently attracted a great attention owing to their unique tuneable nature that enables the proper choice of their composition (cation and organic linker) and structure to render them nontoxic and biodegradable. [7][8][9] In addition to their high and regular porosity, their internal amphiphilic microenvironment, well-adapted to host diverse therapeutic guests, leads in most cases to exceptional high loadings and a controlled release of the entrapped drugs under simulated physiological conditions. Despite their remarkable properties, reports dealing with the external surface of nanoMOFs are still scarce.…”

Section: Introductionmentioning

confidence: 99%

Heparin‐Engineered Mesoporous Iron Metal‐Organic Framework Nanoparticles: Toward Stealth Drug Nanocarriers

Bellido

Hidalgo

Lozano

et al. 2015

Adv Healthcare Materials

191

152

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The specific modification of the outer surface of the promising porous metal-organic framework nanocarriers (nanoMOFs) preserving their characteristic porosity is still a major challenge. Here a simple, fast, and biofriendly method for the external functionalization of the benchmarked mesoporous iron(III) trimesate nanoparticles MIL-100(Fe) with heparin, a biopolymer associated with longer-blood circulation times is reported. First, the coated nanoparticles showed intact crystalline structure and porosity with improved colloidal stability under simulated physiological conditions, preserving in addition its encapsulation and controlled release capacities. The effect of the heparin coating on the nanoMOF interactions with the biological environment is evaluated through cell uptake, cytotoxicity, oxidative stress, cytokine production, complement activation, and protein adsorption analysis. These results confirmed that the heparin coating endowed the nanoMOFs with improved biological properties, such as reduced cell recognition, lack of complement activation, and reactive oxygen species production. Overall, the ability to coat the surface of the nanoMOFs using a simple and straight-forward approach could be taken as a way to enhance the versatility and, thus, the potential of porous MOF nanoparticles in biomedicine.

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“…However, these delivery agents are hindered by several factors. Polymers are cytotoxic and degrade in vivo, promoting immunogenic reactions, and liposomes are prone to leakage which results in decreased efficiency of biomolecule delivery [231,[233][234][235][236][237].…”

Section: Multi-modal Treatmentsmentioning

confidence: 99%

Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

2016

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By electrodeposition and galvanic replacement reaction, we developed a facile, time-saving, cost-effective, and environmentally friendly, two-step synthesis route to obtain a controllable cobalt oxide/Au hierarchically nanostructured electrode for glucose sensing. The nanomaterials were characterized by transmission electron microscopy, scanning electron microscopy, Raman spectroscopy, energy-dispersive spectrometry, and X-ray photoelectron spectroscopy, meanwhile, the sensing performance was investigated by cyclic voltammetry and amperometric response. The results revealed that this novel electrode exhibited excellent electrocatalytic performance toward glucose oxidation, with a wide double-linear range from 0.2 μM to 20 mM and a low detection limit of 0.1 μM based on a signal-to-noise ratio of 3, which was mainly attributed to the ability of loading a small amount of Au with good electron conductivity on the surface of cobalt oxide nanosheets with large active surface area and synergistic electrocatalytic activity of Au and cobalt oxide toward glucose electrooxidation. This facile, sensitive, and selective glucose sensor is also proven to be suitable for the detection of glucose in human serum.

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Coordination polymer nanoparticles in medicine

Cited by 166 publications

References 79 publications

BSA-assisted synthesis of ultrasmall gallic acid–Fe(III) coordination polymer nanoparticles for cancer theranostics

BSA-assisted synthesis of ultrasmall gallic acid–Fe(III) coordination polymer nanoparticles for cancer theranostics

Heparin‐Engineered Mesoporous Iron Metal‐Organic Framework Nanoparticles: Toward Stealth Drug Nanocarriers

Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

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Coordination polymer nanoparticles in medicine

Cited by 166 publications

References 79 publications

BSA-assisted synthesis of ultrasmall gallic acid&ndash;Fe(III) coordination polymer nanoparticles for cancer theranostics

BSA-assisted synthesis of ultrasmall gallic acid&ndash;Fe(III) coordination polymer nanoparticles for cancer theranostics

Heparin‐Engineered Mesoporous Iron Metal‐Organic Framework Nanoparticles: Toward Stealth Drug Nanocarriers

Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

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BSA-assisted synthesis of ultrasmall gallic acid–Fe(III) coordination polymer nanoparticles for cancer theranostics

BSA-assisted synthesis of ultrasmall gallic acid–Fe(III) coordination polymer nanoparticles for cancer theranostics