Coordination compounds of palladium(II) and platinum(II) with benzotriazoles

Kovala‐Demertzi, Dimitra; Perlepes, Spyros P.

doi:10.1007/bf00166256

Cited by 10 publications

(1 citation statement)

References 27 publications

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“…[19][20][21] Thus, this complex has a trans disposition analogous to that shown in complex 1. 12 The 1 H and 13 C NMR assignations for the ligands and the complexes are given in Tables 1 and 2.…”

Section: Synthesis and Characterization Of The Compoundsmentioning

confidence: 74%

Pd(II) and Pt(II) Complexes of 2-Phenyl- and 2-Benzyl-imidazoline: Synthesis, Structural Characterization, DNA Modification andin vitro Antileukaemic Activity

Zamora

González²,

Pérez³

et al. 1997

Appl. Organometal. Chem.

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In this paper we describe the synthesis and chemical characterization of three new Pd(II)–imidazoline complexes: [PdCl2 (C6H5–CH2–C3H5N2)2] (2), [PdCl(SEt2) (C6H4‐C3H5N2)] (5) and [Pd(C6H4‐C3H5N2) (μ‐Br)]2 (6). We have also analyzed the DNA modifications and in vitro antileukaemic activity of these compounds and of their previously reported analogs [Pd Cl2 (C6H5–C3H5N2)2] (1), [Pd (C6H4–C3H5N2) (μ‐OAc)]2 (3), [Pd (C6H4–C3H5N2) (μ‐Cl)]2 (4) and [Pt(C6H4–C3H5N2)(μ‐Cl] (7). All these compounds modify the DNA secondary structure since they alter the melting temperature (Tm) of the DNA. Circular dichroism spectra indicated, moreover, that compounds 3, 5 and 6 induced higher modification on the double helix than compounds 1, 2 and 4. While compounds 1, 2 and 5 seem to induce slight changes in the electrophoretic mobility of the open and covalently closed circular forms of pUC8 DNA at high ri (input molar ratio of Pd or Pt to nucleotides), compounds 3, 6 and 7 do not modify at any ri the tertiary structure of the plasmid DNA. Antileukaemic tests suggest that compounds 1, 4 and 7 exhibit important cytotoxic activity since their IC50 values against HL‐60 human leukaemic cells were below 10 μg ml−1. © 1997 John Wiley & Sons, Ltd.

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