Coordinate regulation between the nuclear receptor peroxisome proliferator-activated receptor-γ and cyclooxygenase-2 in renal epithelial cells

Casali, Cecilia I.; Weber, Karen; Faggionato, Daniela; Gómez, Emanuel Morel; Tome, María C. Fernández

doi:10.1016/j.bcp.2014.06.002

Cited by 4 publications

(4 citation statements)

References 55 publications

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“…11 Moreover, peroxisome proliferator-activated receptor delta (PPARδ) and glycogen synthase kinase 3β (GSK 3β) have also been reported to be involved in RMIC survival under hypertonic stress. 12,13 In the present study, we report that FXR is constitutively expressed in RMICs, which are under the same osmotic stress as the collecting duct epithelial cells in the kidney. We found that FXR plays an important role in protecting RMICs from hypertonicity-induced cell damage via the NF-κB/FXR/TonEBP pathway.…”

supporting

confidence: 52%

“… 11 Moreover, peroxisome proliferator‐activated receptor delta (PPARδ) and glycogen synthase kinase 3β (GSK 3β) have also been reported to be involved in RMIC survival under hypertonic stress. 12 , 13 …”

Section: Introductionmentioning

confidence: 99%

“…have previously reported that water deprivation and hypertonicity can activate NF‐κB and increase cyclooxygenase‐2 (COX‐2) expression to favour RMICs survival in hypertonic conditions 11 . Moreover, peroxisome proliferator‐activated receptor delta (PPARδ) and glycogen synthase kinase 3β (GSK 3β) have also been reported to be involved in RMIC survival under hypertonic stress 12,13 …”

Section: Introductionmentioning

confidence: 99%

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The NF‐κB/FXR/TonEBP pathway protects renal medullary interstitial cells against hypertonic stress

Du,

Hu,

et al. 2024

J Cellular Molecular Medi

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Farnesoid X receptor (FXR), a ligand‐activated transcription factor, plays an important role in maintaining water homeostasis by up‐regulating aquaporin 2 (AQP2) expression in renal medullary collecting ducts; however, its role in the survival of renal medullary interstitial cells (RMICs) under hypertonic conditions remains unclear. We cultured primary mouse RMICs and found that the FXR was expressed constitutively in RMICs, and that its expression was significantly up‐regulated at both mRNA and protein levels by hypertonic stress. Using luciferase and ChIP assays, we found a potential binding site of nuclear factor kappa‐B (NF‐κB) located in the FXR gene promoter which can be bound and activated by NF‐κB. Moreover, hypertonic stress‐induced cell death in RMICs was significantly attenuated by FXR activation but worsened by FXR inhibition. Furthermore, FXR increased the expression and nuclear translocation of hypertonicity‐induced tonicity‐responsive enhance‐binding protein (TonEBP), the expressions of its downstream target gene sodium myo‐inositol transporter (SMIT), and heat shock protein 70 (HSP70). The present study demonstrates that the NF‐κB/FXR/TonEBP pathway protects RMICs against hypertonic stress.

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supporting

confidence: 52%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The NF‐κB/FXR/TonEBP pathway protects renal medullary interstitial cells against hypertonic stress

Du,

Hu,

et al. 2024

J Cellular Molecular Medi

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“…It is also interesting to note that Casali et al reported that the decrease in the nuclear receptor peroxisome proliferator-activated receptor-γ (PPARγ) expression was required for hyperosmotic induction of COX-2 in renal epithelial cells MDCK. (31) Collecting duct PPARγ is shown to contribute to thiazolidinedione-induced fluid retention, a major side effect of the antidiabetic agent (32). It will be an interesting subject concerning the interaction between PPARγ and COX-2 in regulation of collecting duct function particularly during antidiuresis.…”

Section: Discussionmentioning

confidence: 99%

Regulation and function of renal medullary cyclooxygenase-2 during high salt loading

Yang

Liu

2017

Front Biosci

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Prostaglandins (PGs) are important autocrine/paracrine regulators that contribute to sodium balance and blood pressure control. Along the nephron, the highest amount of PGE2 is found in the distal nephron, an important site for fine-tuning of urinary sodium and water excretion. Cylooxygenase-2 (COX-2) is abundantly expressed in the renal medulla and its expression along with urinary PGE2 excretion is highly induced by chronic salt loading. Factors involved in high salt-induced COX-2 expression in the renal medulla include the hypertonicity, fluid shear stress (FSS), and hypoxia-inducible factor-1α (HIF-1 α). Site-specific inhibition of COX-2 in the renal medulla of Sprague-Dawley rats causes sodium retention and salt-sensitive hypertension. Together, these results support the concept that renal medullary COX-2 functions an important natriuretic mediator that is activated by salt loading and its products promote sodium excretion and contribute to maintenance of sodium balance and blood pressure.

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Ins and Outs of Interpreting Lipidomic Results

Bestard-Escalas

Maimó-Barceló

Pérez-Romero

et al. 2019

Journal of Molecular Biology

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Coordinate regulation between the nuclear receptor peroxisome proliferator-activated receptor-γ and cyclooxygenase-2 in renal epithelial cells

Cited by 4 publications

References 55 publications

The NF‐κB/FXR/TonEBP pathway protects renal medullary interstitial cells against hypertonic stress

The NF‐κB/FXR/TonEBP pathway protects renal medullary interstitial cells against hypertonic stress

Regulation and function of renal medullary cyclooxygenase-2 during high salt loading

Ins and Outs of Interpreting Lipidomic Results

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