Coordinate regulation and synergistic actions of BMP4, SHH and FGF8 in the rostral prosencephalon regulate morphogenesis of the telencephalic and optic vesicles

Ohkubo, Yasushi; Chiang, Chin; Rubenstein, John L.R.

doi:10.1016/s0306-4522(01)00616-9

Cited by 263 publications

(296 citation statements)

References 86 publications

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“…Shh expression is specifically lost in the MGE but not in the HT of both Fgf8 TelKO single and Fgf3 Ϫ/Ϫ ; Fgf8 TelKO double mutants (Fig. 4H,I) consistent with the requirement for Fgf8 in the maintenance of Shh expression in the ventral telencephalon (Ohkubo et al, 2002;Storm et al, 2006). Collectively, these data suggest that the dorsal and ventral signaling centers in Fgf8 TelKO and Fgf3 Ϫ/Ϫ ;Fgf8 TelKO mutants are affected to similar degrees and that the Fgf3 mutation does not increase the severity of these defects.…”

Section: Fgf3 Does Not Cooperate With Fgf8 During Forebrain Patterninsupporting

confidence: 64%

“…To analyze whether patterning of the telencephalon is affected in mutants lacking telencephalic Fgf3 and Fgf8 expression we performed in situ hybridizations on coronal sections of the E10.5 telencephalon of wild-type, 1997; Grove et al, 1998;Ohkubo et al, 2002;Shimogori et al, 2004). In the Fgf8 TelKO as well as in the Fgf3 Ϫ/Ϫ ;Fgf8 TelKO double mutant, both genes show slightly expanded expression domains in the dorsal telencephalon ( Fig.…”

Section: Fgf3 Does Not Cooperate With Fgf8 During Forebrain Patterninmentioning

confidence: 99%

“…Three different signaling centers have been identified, including the dorsal midline that expresses Bmps (Furuta et al, 1997) and Wnts (Grove et al, 1998;Lee et al, 2000), the rostral midline expressing Fgfs (Crossley and Martin, 1995;McWhirter et al, 1997;Maruoka et al, 1998;Walshe and Mason, 2003) and the ventral midline characterized by Shh expression (Ericson et al, 1995). Bmps and Wnts have been shown to act antagonistically to Fgf and Shh (Ohkubo et al, 2002;Kuschel et al, 2003;Storm et al, 2003;Shimogori et al, 2004). Modifications in the relative strength of these signaling centers have thus profound effects on the size and nature of telencephalic subdivisions by regulating the expression of transcription factors, such as Nkx2.1, Emx2, and Pax6 (Sussel et al, 1999;Stoykova et al, 2000;Muzio et al, 2002;Theil et al, 2002;Fuccillo et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

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Differential requirements for Fgf3 and Fgf8 during mouse forebrain development

Theil

Domínguez-Frutos

Schimmang

2008

Developmental Dynamics

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Section: Fgf3 Does Not Cooperate With Fgf8 During Forebrain Patterninsupporting

confidence: 64%

Section: Fgf3 Does Not Cooperate With Fgf8 During Forebrain Patterninmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Differential requirements for Fgf3 and Fgf8 during mouse forebrain development

Theil

Domínguez-Frutos

Schimmang

2008

Developmental Dynamics

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“…Alternatively, Gli3 might be required to maintain dorsal-medial r1 identity, and the expansion of Fgf8 expression is a secondary consequence of a mixed r1/isthmus identity. Interestingly, a similar interaction between Shh, Gli3 and Fgf8 exists in the developing telencephalon (Gutin et al, 2006;Kuschel et al, 2003;Ohkubo et al, 2002), suggesting that the interplay between these two signaling pathways constitutes a more general mechanism in the patterning of three-dimensional brain structures.…”

Section: Gli3r Is Required To Restrict Fgf8 Expression To the Isthmusmentioning

confidence: 98%

Gli3 coordinates three-dimensional patterning and growth of the tectum and cerebellum by integrating Shh and Fgf8 signaling

2008

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The coordination of anterior-posterior (AP) and dorsal-ventral (DV) patterning of the mesencephalon (mes) and rhombomere 1 (r1) is instrumental for the development of three distinct brain structures: the tectum and cerebellum dorsally and the tegmentum ventrally. Patterning of the mes/r1 is primarily mediated by signaling molecules secreted from two organizers: sonic hedgehog (Shh) from the floor plate (DV) and Fgf8 from the isthmus (AP). Gli3, a zinc-finger transcription factor in the Shh signaling pathway, has been implicated in regulating Fgf8 expression and is therefore a potential candidate for coordinating the action of the two organizers. By inactivating mouse Gli3 at successive embryonic time points in vivo, we uncovered the extent and the underlying mechanism of Gli3 function in the mes/r1. We demonstrate that before E9.0, Gli3 is required for establishing a distinct posterior tectum, isthmus and cerebellum, but does not play a role in the development of the tegmentum. Between E9.0 and E11.0, Gli3 continues to be required for isthmus and cerebellum development, but primarily for defining the cerebellar foliation pattern. We show that Gli3 regulates patterning of the isthmus and cerebellar anlage by confining Fgf8 expression to the isthmus, and attenuates growth of dorsal r1 (before E11.0) and the dorsal mes and isthmus (beyond E11.0) through regulation of cell proliferation and viability. In conclusion, our results show that Gli3 is essential for the coordinated three-dimensional patterning and growth of the dorsal mes/r1. KEY WORDS: Anterior-posterior patterning, Dorsal-ventral patterning, Isthmic organizer, Mid/hindbrain, Mouse

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“…Mice null for Twisted gastrulation (Twsg1), which is thought to act as a BMP inhibitor, also shows a similar range of midline truncations (Petryk et al, 2004). In similar manner, increased BMP signaling by means of application of ectopic BMP proteins to the anterior, ventral forebrain yields cyclopic chicks and reduces regional Shh and Fgf8 expression (Golden et al, 1999;Ohkubo et al, 2002).…”

Section: From Organizer To Mesendoderm To Pharyngeal Endoderm: Succesmentioning

confidence: 99%

21^st Century neontology and the comparative development of the vertebrate skull

Depew

Simpson

2006

Developmental Dynamics

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Classic neontology (comparative embryology and anatomy), through the application of the concept of homology, has demonstrated that the development of the gnathostome (jawed vertebrate) skull is characterized both by a fidelity to the gnathostome bauplan and the exquisite elaboration of final structural design. Just as homology is an old concept amended for modern purposes, so are many of the questions regarding the development of the skull. With due deference to Geoffroy-St. Hilaire, Cuvier, Owen, Lankester et al., we are still asking: How are bauplan fidelity and elaboration of design maintained, coordinated, and modified to generate the amazing diversity seen in cranial morphologies? What establishes and maintains pattern in the skull? Are there universal developmental mechanisms underlying gnathostome autapomorphic structural traits? Can we detect and identify the etiologies of heterotopic (change in the topology of a developmental event), heterochronic (change in the timing of a developmental event), and heterofacient (change in the active capacetence, or the elaboration of capacity, of a developmental event) changes in craniofacial development within and between taxa? To address whether jaws are all made in a like manner (and if not, then how not), one needs a starting point for the sake of comparison. To this end, we present here a "hinge and caps" model that places the articulation, and subsequently the polarity and modularity, of the upper and lower jaws in the context of cranial neural crest competence to respond to positionally located epithelial signals. This model expands on an evolving model of polarity within the mandibular arch and seeks to explain a developmental patterning system that apparently keeps gnathostome jaws in functional registration yet tractable to potential changes in functional demands over time. It relies upon a system for the establishment of positional information where pattern and placement of the "hinge" is driven by factors common to the junction of the maxillary and mandibular branches of the first arch and of the "caps" by the signals emanating from the distal-most first arch midline and the lamboidal junction (where the maxillary branch meets the frontonasal processes). In this particular model, the functional registration of jaws is achieved by the integration of "hinge" and "caps" signaling, with the "caps" sharing at some critical level a developmental history that potentiates their own coordination. We examine the evidential foundation for this model in mice, examine the robustness with which it can be applied to other taxa, and examine potential proximate sources of the signaling centers. Lastly, as developmental biologists have long held that the anterior-most mesendoderm (anterior archenteron roof or prechordal plate) is in some way integral to the normal formation of the head, including the cranial skeletal midlines, we review evidence that the seminal patterning influences on the early anterior ectoderm extend well beyond the neural plate and are just as importan...

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Coordinate regulation and synergistic actions of BMP4, SHH and FGF8 in the rostral prosencephalon regulate morphogenesis of the telencephalic and optic vesicles

Cited by 263 publications

References 86 publications

Differential requirements for Fgf3 and Fgf8 during mouse forebrain development

Differential requirements for Fgf3 and Fgf8 during mouse forebrain development

Gli3 coordinates three-dimensional patterning and growth of the tectum and cerebellum by integrating Shh and Fgf8 signaling

21^st Century neontology and the comparative development of the vertebrate skull

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Coordinate regulation and synergistic actions of BMP4, SHH and FGF8 in the rostral prosencephalon regulate morphogenesis of the telencephalic and optic vesicles

Cited by 263 publications

References 86 publications

Differential requirements for Fgf3 and Fgf8 during mouse forebrain development

Differential requirements for Fgf3 and Fgf8 during mouse forebrain development

Gli3 coordinates three-dimensional patterning and growth of the tectum and cerebellum by integrating Shh and Fgf8 signaling

21st Century neontology and the comparative development of the vertebrate skull

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21^st Century neontology and the comparative development of the vertebrate skull