Cook-Heilbron thiazole synthesis

Li, Jie Jack

doi:10.1007/978-3-662-05336-2_66

Cited by 2 publications

(1 citation statement)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thiazole undergoes various reactions such as donor-acceptor [3], intramolecular nucleophilic substitution [4], photochemical reaction [5,6], arylation [7], cycloaddition [8], oxidation [9], transformation [10], dimerization [11], etc. Some old but important methods for the production of thiazole rings include Hantzsch thiazole synthesis [12,13], Cook-Heilbron synthesis [14], Herz synthesis [15], modified Hantzsch synthesis [16], etc. Recently, thiazole derivatives have been synthesized by Venugopala (2017) [17].…”

Section: Introductionmentioning

confidence: 99%

Thiazole: A Versatile Standalone Moiety Contributing to the Development of Various Drugs and Biologically Active Agents

Arshad¹,

Alam

Alshammari

et al. 2022

Molecules

View full text Add to dashboard Cite

For many decades, the thiazole moiety has been an important heterocycle in the world of chemistry. The thiazole ring consists of sulfur and nitrogen in such a fashion that the pi (π) electrons are free to move from one bond to other bonds rendering aromatic ring properties. On account of its aromaticity, the ring has many reactive positions where donor–acceptor, nucleophilic, oxidation reactions, etc., may take place. Molecules containing a thiazole ring, when entering physiological systems, behave unpredictably and reset the system differently. These molecules may activate/stop the biochemical pathways and enzymes or stimulate/block the receptors in the biological systems. Therefore, medicinal chemists have been focusing their efforts on thiazole-bearing compounds in order to develop novel therapeutic agents for a variety of pathological conditions. This review attempts to inform the readers on three major classes of thiazole-bearing molecules: Thiazoles as treatment drugs, thiazoles in clinical trials, and thiazoles in preclinical and developmental stages. A compilation of preclinical and developmental thiazole-bearing molecules is presented, focusing on their brief synthetic description and preclinical studies relating to structure-based activity analysis. The authors expect that the current review may succeed in drawing the attention of medicinal chemists to finding new leads, which may later be translated into new drugs.

show abstract

Section: Introductionmentioning

confidence: 99%

Thiazole: A Versatile Standalone Moiety Contributing to the Development of Various Drugs and Biologically Active Agents

Arshad¹,

Alam

Alshammari

et al. 2022

Molecules

View full text Add to dashboard Cite

show abstract

A Review on Synthesis and Biological Activity of Thiazole and its Derivatives

Th¹,

Nair²,

Kumar³

et al. 2021

IJPSRR

View full text Add to dashboard Cite

Thiazole, a five-membered heteroaromatic ring, is an important framework of a large number of synthetic compounds. Its diverse pharmacological activity is mirrored in many clinically approved thiazole-containing molecules with, wide range of biological activities, such as antibacterial, antifungal, antiviral, anthelmintic, antitumor, and anti-inflammatory effects. The current review provides an overview of the biological activities of thiazole during the past years.

show abstract

Cook-Heilbron thiazole synthesis

Cited by 2 publications

References 2 publications

Thiazole: A Versatile Standalone Moiety Contributing to the Development of Various Drugs and Biologically Active Agents

Thiazole: A Versatile Standalone Moiety Contributing to the Development of Various Drugs and Biologically Active Agents

A Review on Synthesis and Biological Activity of Thiazole and its Derivatives

Contact Info

Product

Resources

About