Convexity Subarachnoid Hemorrhage in Cerebral Amyloid Angiopathy: The Saga Continues

Abstract

for their very useful comments on an earlier version of the illustration included in the manuscript.

Cortical superficial siderosis and recurrent intracerebral hemorrhage risk in cerebral amyloid angiopathy: Large prospective cohort and preliminary meta-analysis

“…Our observations from the single-center prospective cohort and a preliminary meta-analysis of currently available data provide firm support for cSS as a central biomarker of hemorrhagic small vessel associated pathology. [30][31][32] Both presence and extent of cSS, have prognostic relevance in CAA patients, since they consistently increase future lobar ICH recurrence risk with potential implications for clinical decision making in the field (e.g. avoiding antithrombotic agents) and future disease-modifying treatments.…”

Cortical superficial siderosis multifocality in cerebral amyloid angiopathy

“…10 Taken together, our observations further support the notion that cSS is a central component of hemorrhagic small vessel disease and can potentially identify new mechanisms and distinct CAA phenotypes. [31][32][33] cSS multifocality seems to consistently increase the risk of future lobar ICH recurrence with important clinical implications for patients with CAA and future disease-modifying treatments. More work is needed into potential pathophysiologic mechanisms of cSS; the multifocality scale suggested here might facilitate such future studies.…”

Cortical superficial siderosis and first-ever cerebral hemorrhage in cerebral amyloid angiopathy

“…hemorrhagic CAA brain injury and can identify new mechanisms and distinct CAA phenotypes. 2,38,39 The increased risk of future CAA-related lobar ICH associated with cSS may have important clinical implications for patient care, particularly in evaluating the risk vs benefit of antithrombotic agents, and for use of any future disease-modifying treatments. 40…”