Conversion to dementia in mild cognitive impairment diagnosed with <scp>DSM</scp>‐5 criteria and with Petersen's criteria

Marcos, Guillermo; Santabárbara, Javier; López-Antón, Raúl; De‐la‐Cámara, Concepción; Gracia-García, Patricia; Lobo, Elena; Pírez, Guillermo; Menchón, J.M.; Palomo, Tomás; Stephan, Blossom C. M.; Brayne, Carol; Lobò, Antonio; Workgroup, Zarademp

doi:10.1111/acps.12543

Cited by 40 publications

(29 citation statements)

References 36 publications

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“…The risk estimation found by Gulpers et al [14] was twice as high as what we found in this study and our previous meta-analysis [15]. The main reason for this difference could be that three out of six community samples investigated by Gulpers et al were comprised entirely of individuals with mild cognitive impairment at baseline, and who might have a higher risk of conversion to dementia than cognitively intact subjects [37]. In our meta-analysis, all studies excluded prevalent demented participants, and all but one [13] excluded participants with cognitive impairment at baseline (e.g., measured with the MMSE) or controlled for baseline cognition in the analysis.…”

Section: Comparison With Previous Studiescontrasting

confidence: 69%

Does Anxiety Increase the Risk of all-Cause Dementia? An Updated Meta-Analysis of Prospective Cohort Studies

Santabárbara

Lipnicki

Olaya

et al. 2020

JCM

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Background: Anxiety has been suggested as a potentially modifiable risk factor for dementia, but results are still controversial. Our main objectives are to develop an updated meta-analysis of prospective population-based studies on the relationship between anxiety and risk of dementia, and to estimate the population fraction of dementia attributable to anxiety (PAF). Methods: We searched for cohort studies listed on PubMed or Web of Science from January 2018 to January 2020 that reported risk estimates for the association between anxiety and incident dementia. These were added to cohort studies published before January 2018 that were used in a previously published meta-analysis. Fully adjusted RRs were pooled using random effects models. We estimated the proportion of incident dementia attributable to anxiety by using PAF. Results: The meta-analysis included nine prospective cohorts from eight studies, representing 29,608 participants. The overall relative risk (RR) of dementia was 1.24 (95% CI: 1.06–1.46) and the PAF of dementia due to anxiety was 3.9%. Conclusions: Anxiety is significantly associated with an increased risk of all-cause dementia. The treatment or prevention of anxiety might help to reduce dementia incidence rates, but more research is needed to clarify whether anxiety is a cause of dementia rather than a prodrome.

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Section: Comparison With Previous Studiescontrasting

confidence: 69%

Does Anxiety Increase the Risk of all-Cause Dementia? An Updated Meta-Analysis of Prospective Cohort Studies

Santabárbara

Lipnicki

Olaya

et al. 2020

JCM

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“…In a large population-based study of 4057 individuals with 4.5 years follow-up, DSM-5 criteria gave a higher annual progression rate than Petersen criteria for progression to Alzheimer's disease dementia and to all-cause dementia. 66 However, the majority of people who developed Alzheimer's disease dementia were classified as normal controls at baseline. The DSM-5 criteria were more restrictive, with only 139 cases meeting criteria, whereas 303 cases met criteria for Petersen aMCI.…”

Section: Subtype and Progression To Alzheimer's Disease Dementiamentioning

confidence: 99%

Mild cognitive impairment: narrative review of taxonomies and systematic review of their prediction of incident Alzheimer's disease dementia

Bradfield

Ames

2019

BJPsych Bull

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Early detection of Alzheimer's disease is vital for developing novel treatments. Attempts to identify the intermediate state between normal cognition and dementia have evolved over the past 50 years. Current taxonomies of mild cognitive impairment (MCI) may be criticised for their imprecise operationalisation. With the advent of biomarkers such as amyloid-beta positron emission tomography imaging in established Alzheimer's disease, much research has focused on establishing which factors predict progression from MCI to Alzheimer's disease dementia. In this review, we discuss the historical context of MCI before reviewing the literature of MCI subtypes and their risk of progression to Alzheimer's disease dementia. Finally, we summarise the literature and discuss limitations and weaknesses of how the construct is operationalised and implemented, before offering suggestions for development of the concept of MCI. We conclude that MCI must be empirically defined for the sake of its predictive validity to identify Alzheimer's disease before dementia develops.

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“…[13][14][15] However, a consensus has been reached that reviewing modifiable factors in daily living would be beneficial for prevention of progression, 16 and that multi-domain intervention is more effective than single domain interventions, including exercise. Thus, in patients with MCI, intervention to prevent conversion to dementia is also important.…”

Section: Mild Cognitive Impairment: Prevention Of Conversion To Dementiamentioning

confidence: 99%

“…The proportion of conversion to dementia and that of reversion to a normal status differ among studies, and related factors are still under research. [13][14][15] However, a consensus has been reached that reviewing modifiable factors in daily living would be beneficial for prevention of progression, 16 and that multi-domain intervention is more effective than single domain interventions, including exercise. The current issues are the choice and combination of target factors.…”

Section: Mild Cognitive Impairment: Prevention Of Conversion To Dementiamentioning

confidence: 99%

Rehabilitation to live better with dementia

Maki

Sakurai

Okochi³

et al. 2018

Geriatrics Gerontology Int

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The goal of dementia treatment is to improve the quality of life for both people with dementia and their families. Rehabilitation as a non‐pharmacological approach, coordinated with pharmacological treatment, aims to allow patients to live better by slowing the progression, and relieving the behavioral and psychological symptoms of dementia. In dementia, the manifestation of symptoms caused by neurological impairment is modified by various factors; thus, multidimensional assessment and approaches are effective based on the concept of the International Classification of Functioning, which emphasizes the healthy components of every person's functioning. Regarding the process of rehabilitation, every person with dementia should take initiative throughout the course of rehabilitation, and shared decision‐making is a fundamental requirement at every phase of intervention. The needs of rehabilitation differ depending on the stage of dementia. In the early stages, cognitive rehabilitation is needed, and interventions are carried out using preserved functions and compensatory strategies. As the disease progresses, capacities of instrumental and then basic activities of daily living deteriorate, and interventions need to be tailor‐made and carried out in the context of actual living situations. In the early‐to‐moderate stages, prevention and management of behavioral and psychological symptoms of dementia are required. In the interventions to alleviate behavioral and psychological symptoms of dementia, it is critical to consider the individual and the meaning behind his/her behaviors from a holistic perspective. Family carers also need support, and education to learn coping strategies can be beneficial for both people with dementia and their carers. Rehabilitation can empower people with dementia and their families to live better with dementia. Geriatr Gerontol Int 2018; 18: 1529–1536.

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Conversion to dementia in mild cognitive impairment diagnosed with DSM‐5 criteria and with Petersen's criteria

Abstract: Conversion rate to dementia and AD was higher using DSM-5-MCI criteria than using Petersen's criteria. However, prediction of the construct still has some way to go, as most MCI individuals did not convert at 4.5-year follow-up.

Cited by 40 publications

References 36 publications

Does Anxiety Increase the Risk of all-Cause Dementia? An Updated Meta-Analysis of Prospective Cohort Studies

Does Anxiety Increase the Risk of all-Cause Dementia? An Updated Meta-Analysis of Prospective Cohort Studies

Mild cognitive impairment: narrative review of taxonomies and systematic review of their prediction of incident Alzheimer's disease dementia

Rehabilitation to live better with dementia

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