Does Anxiety Increase the Risk of all-Cause Dementia? An Updated Meta-Analysis of Prospective Cohort Studies

Santabárbara, Javier; Lipnicki, Darren M.; Olaya, Beatriz; Villagrasa, Beatriz; Nuez, Lucia; López-Antón, Raúl; Gracia-García, Patricia

doi:10.3390/jcm9061791

Cited by 44 publications

(35 citation statements)

References 58 publications

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“…Our analyses highlighted the relationship between the engagement in those activities and depressive symptoms. Depression has been widely recognised as an important risk factor for dementia (Santabárbara et al, 2020). In light of our present findings, it may be that symptomatology connected with depression reduces opportunities for engagement in leisure activities such as playing chess or cards.…”

Section: Incorrect Cdt (%)supporting

confidence: 49%

Selected sociodemographic and clinic alpredictors of the clock drawing test performance in Polish community dwelling seniors

Chibowska¹,

Nowicka-Sauer²,

Sitek³

2020

Aktualn Neurol

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Objectives: The clock drawing test (CDT) is a commonly used cognitive screening test. The purpose of this study was to investigate the effect of selected sociodemographic, clinical and lifestyle factors on the CDT performance in the Polish elderly population. Methods: CDT performance was assessed in 399 elderly subjects randomly selected out of all participants of a nationwide study on aging, PolSenior2, who met the inclusion criteria. CDT was scored using the Manos–Wu method. The short version of the Geriatric Depression Scale (15-item GDS) was used as a mood measuring tool. Results: Our study revealed a significant relationship between CDT performance and age. Multivariate regression analysis demonstrated also that interactions between reading newspapers and gender and between playing games and GDS score were independent predictors of an incorrect CDT. Of note, even though years of education were related to the CDT score (0–10) in the correlation analysis, education did not predict the global CDT score in the regression analysis. Conclusions: Advanced age was related to incorrect CDT performance. Engagement in some leisure activities may predict the CDT score, while global CDT performance, as assessed by the Manos–Wu method, is relatively unaffected by education.

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Section: Incorrect Cdt (%)supporting

confidence: 49%

Selected sociodemographic and clinic alpredictors of the clock drawing test performance in Polish community dwelling seniors

Chibowska¹,

Nowicka-Sauer²,

Sitek³

2020

Aktualn Neurol

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“…It is now well recognized that anxiety disorders impose an alarming burden on public health as individuals with this disorder can experience significant disruption in their daily function, productivity, and quality of life (Correa & Brown, 2019; Nilsson et al., 2019; Santabarbara et al., 2020). Moreover, anxiety can look or manifest differently at different ages in humans.…”

Section: Discussionmentioning

confidence: 99%

Age‐related behavioral and ultrastructural changes in the rat amygdala

Lomidze¹,

Zhvania²,

Tizabi

et al. 2020

Developmental Neurobiology

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Although the relationships between brain structure and emotions may alter across the life span, this relationship is of particular importance during aging when significant alterations in emotions may be manifested. Understanding the structural–behavioral relationship could not only provide a neurobiological basis of these changes, but could also suggest potential intervention. Since anxiety is commonly observed in aging population, we undertook this study to determine the extent of this behavioral manifestations as well as the associated ultrastructural changes in the amygdala. Rats of various age groups, adolescent, adult, and aged were tested for anxiety‐like behavior and the ultrastructure/presynaptic architecture of the central nucleus of amygdala (CNA) were evaluated using transmission electron microscopy (EM). Aged rats were consistently more anxious than the other groups as evidenced by their scores in the elevated plus maze. Morphometric EM analysis of axodendritic synapses revealed that the aged rats had a lower presynaptic area as well as number of synapses, but unexpectedly a higher number of presynaptic mitochondria in CNA. Since presynaptic mitochondria are known to provide the energy for neurotransmission, it may be concluded that compensatory mechanisms are still operational during aging, and hence, may be a target for therapeutic intervention at this stage of life span.

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“…The notion that anxiety is common among people with cognitive deterioration is widely accepted [1,2,7,8]. However, the prevalence of anxiety among people with MCI is unclear.…”

Section: Introductionmentioning

confidence: 99%

Association of Anxiety Awareness with Risk Factors of Cognitive Decline in MCI

Gigi

Papirovitz

2021

Brain Sciences

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Studies demonstrate that anxiety is a risk factor for cognitive decline. However, there are also study findings regarding anxiety incidence among people with mild cognitive impairment (MCI), which mostly examined general anxiety evaluated by subjective questionnaires. This study aimed to compare subjective and objective anxiety (using autonomic measures) and anxiety as a general tendency and anxiety as a reaction to memory examination. Participants were 50 adults aged 59–82 years who were divided into two groups: MCI group and control group, according to their objective cognitive performance in the Rey Auditory Verbal Learning Test. Objective changes in the anxiety response were measured by skin conductivity in all tests and questionnaires. To evaluate subjective anxiety as a reaction to memory loss, a questionnaire on “state-anxiety” was used immediately after completing memory tests. Our main finding was that although both healthy and memory-impaired participants exhibited elevations in physiological arousal during the memory test, only healthy participants reported an enhanced state anxiety (p = 0.025). Our results suggest that people with MCI have impaired awareness of their emotional state.

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Does Anxiety Increase the Risk of all-Cause Dementia? An Updated Meta-Analysis of Prospective Cohort Studies

Cited by 44 publications

References 58 publications

Selected sociodemographic and clinic alpredictors of the clock drawing test performance in Polish community dwelling seniors

Selected sociodemographic and clinic alpredictors of the clock drawing test performance in Polish community dwelling seniors

Age‐related behavioral and ultrastructural changes in the rat amygdala

Association of Anxiety Awareness with Risk Factors of Cognitive Decline in MCI

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