Conversion of 2′-substituted chalcones in the presence of BSA as evidenced by 1H NMR studies

Raghav, Neera; Garg, Shweta; Ravish, Indu

doi:10.1016/j.ijbiomac.2015.12.060

Cited by 7 publications

(4 citation statements)

References 27 publications

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“…When at least one of the starting compounds finished, the reaction content was poured on icewater and acidified by HCI (10%). The precipitates obtained was filtered, dried, and recrystallized from ethyl alcohol to obtain compounds 4a-4f (Raghav et al, 2016;Michelini et al, 2018). 3,5diphenyl-4,5-dihydro-1H-pyrazole derivatives (4a-4f) Hydrazine hydrate (80% aqueous solution, 5 mmol) was added to a suspension of 3a-3f (5 mmol) in ethanol 50 mL including 0.5 mL of glacial acetic acid.…”

Section: General Methods For the Preparation Of Chalcone Derivatives (3a-3f)mentioning

confidence: 99%

Yeni pirazolin türevlerinin sentezi ve yapı karakterizasyonu

Çelik¹

2021

Gümüşhane Üniversitesi Fen Bilimleri Enstitüsü Dergisi

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Pyrazolines, which are nitrogen including five-membered heterocyclic structures, have been used in the organic and pharmaceutical industries. This study aimed was to synthesize and characterizes new series of 3,5-diphenyl-4,5-dihydro-1H-pyrazole derivatives. The new pyrazoline compounds have been synthesized from chalcones and hydrazine hydrate in two steps. In the first step, chalcones were synthesized from 2-amino acetophenone and various substituted benzaldehyde by Claisen-Schmidt condensation at room temperature. In second step, starting from various substituted chalcones derivatives with hydrazine hydrate and glacial acetic acid in anhydrous ethanol were synthesized six novel 3,5diphenyl-4,5-dihydro-1H-pyrazole derivatives utilizing intramolecular Michael addition reaction in good yields. The structures of the newly synthesized 3,5-diphenyl-4,5-dihydro-1H-pyrazole derivatives are identified via 1H NMR, 13C NMR, FT-IR, and HRMS.

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Section: General Methods For the Preparation Of Chalcone Derivatives (3a-3f)mentioning

confidence: 99%

Yeni pirazolin türevlerinin sentezi ve yapı karakterizasyonu

Çelik¹

2021

Gümüşhane Üniversitesi Fen Bilimleri Enstitüsü Dergisi

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“…Due to these multifarious applications, many methods are available for synthesis of flavanones viz from 2‐hydroxychalcones, by oxidation of flavan‐4‐ols, by reaction of aldehydes and 1,3‐diones, by alkenyl aryl ethers in the presence of Hg(OCOCF 3 ) 2, by intermolecular Oxa Michael addition of activated α, β‐unsaturated ketones, from thermal, photochemical and electrochemical transformation, by intermolecular C – O addition of carboxylic acids to arynes, by 3‐hydroxy‐1‐(2‐hydroxyphenyl)‐3‐arylpropan‐1‐ones, and by multi‐step reaction between substituted O‐hydroxyacetophenone and substituted benzaldehyde …”

Section: Introductionmentioning

confidence: 92%

pH‐Transformed ZnO‐NPs /NaPTS: The First Room‐Temperature Brisk Synthesis of Flavanones in Aqueous Medium

Shinde¹,

Kamble²,

Pore

et al. 2018

ChemistrySelect

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We investigated pH transformed ZnO NPs viz ZnO nanobullets and ZnO nanograins at pH 11 and 12 respectively, synthesized by co‐precipitation method. The structural, morphological, chemical, compositional and optical properties of synthesized ZnO NPs were analysed by using X‐ray diffraction (XRD), Scanning Electron Microscopy (SEM), Energy Dispersive X‐ray Spectroscopy (EDAX) and Ultra‐Violate Visible spectroscopy (UV‐Vis). The Noteworthy feature of ZnO NPs in presence of NaPTS leads a speedy formation of flavanones from the reaction of an aldehyde and o‐hydroxy acetophenone. Thus, it imparted the first room‐temperature brisk synthesis of flavanones in an aqueous medium.

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“…In vitro serum protein binding activity was assessed using the method reported in the literature. [39][40][41][42] To 0.6 mL of 1 mM solution of synthesized compounds under study added 0.4 mL of 0.4% BSA solution. The resultant solution is stirred for 1 h and then subjected to heat treatment at 72 1C for 10 minutes to precipitate denatured protein.…”

Section: Serum Protecting Activitymentioning

confidence: 99%

“…Serum protein binding can also result in structural modification also. 42 To have an effective pharmacokinetic potential of a drug, it is important that the probable compound should bind to the serum protein to about at least 80-85%. The compounds which bind to serum protein in less than this standard have low clinical significance.…”

Section: Serum Protein Binding Studiesmentioning

confidence: 99%