Syntheses and structural and serum protein protecting activity of ruthenium(ii)–DMSO complexes containing a mercapto ligand

Abstract

Four new ruthenium(II) complexes [Ru(mpt)2(DMSO)2] (1), [Ru(mpt)2(bpy)] (2), [Ru(mpt)2(phen)] (3) and [Ru(mpt)2(tptz)] (4) have been synthesized and characterized by elemental analyses, IR, 1H and 13C NMR, and electronic absorption spectroscopy....

Unravelling the kinetics of electro- and photochemical S → O linkage isomerization in Ru(ii)–NHC–DMSO complexes utilised for photoinduced substitution reactions

“…S13 and S16†), the presence of S-bonded DMSO around the Ru centre in 2a and 2b was confirmed. 33,34,53 Other peaks corresponding to the CN, CC, and C–C stretches were observed in the expected range reported in the literature.…”

“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14] Because of the labile nature of DMSO ligands, these complexes can readily undergo substitution and become compatible with physiological conditions, which is essential for biomedical applications. [15][16][17][18][19] Other pivotal roles of these complexes have also been explored and include application as suitable precursors 4,[20][21][22][23][24][25][26] for the generation of subsequent derivatives having aqua, 27,28 nitrosyl, [29][30][31] carbonyl, 32 polypyridine, 33 and other aromatic ligands. [34][35][36][37][38][39] In addition, the ambidentate nature of the DMSO ligand of Ru-DMSO complexes and its ability to undergo intramolecular and intermolecular S → O linkage isomerization has been extensively studied.…”