Conversion From Twice-Daily to Once-Daily Tacrolimus in Simultaneous Pancreas-Kidney Transplant Patients

First World Consensus Conference on pancreas transplantation: Part II – recommendations

“…Data are available only for SPK transplantation and show that once‐a‐day tacrolimus formulation is associated with excellent patient and graft survival, and that patients can be safely converted from standard tacrolimus to long‐acting tacrolimus. 270 , 271 , 272 , 273 …”

“…Reported experience with the use of once‐a‐day tacrolimus formulation in pancreas transplantation is limited. Data are available only for SPK transplantation and show that once‐a‐day tacrolimus formulation is associated with excellent patient and graft survival, and that patients can be safely converted from standard tacrolimus to long‐acting tacrolimus 270–273 …”

“…Data are available only for SPK transplantation and show that once-a-day tacrolimus formulation is associated with excellent patient and graft survival, and that patients can be safely converted from standard tacrolimus to long-acting tacrolimus. [270][271][272][273] In comparison with cyclosporine, experts agreed that the use of tacrolimus is prevalent in all pancreas transplant categories and is associated with superior immunologic outcomes. No conclusion could be drawn on the comparative efficacy of once-a-day vs. twice-a-day tacrolimus formulations due to lack of supporting data.…”

Simultaneous pancreas and kidney transplantation

“…Once-daily dosing decreases pill burden and may improve medication compliance. Falconer et al [ 26 ] have demonstrated that conversion to this once-daily dosing of tacrolimus has proven safe and effective in the short term. Long-term outcomes with once-daily tacrolimus in pancreas transplantation are forthcoming.…”

Resultados del trasplante de páncreas en pacientes con diabetes mellitus tipo 1 en la Comunidad Valenciana

“…Es por ello, que puede haber oscilaciones en sus concentraciones si se administran con otros fármacos capaces de inducir/inhibir a las enzimas hepáticas. El cambio de posología, de 1 vez cada 12 horas a 1 vez al día, se ha demostrado seguro en cuanto a eficacia y ha favorecido el cumplimiento de la pauta inmunosupresora [92].…”