First World Consensus Conference on pancreas transplantation: Part II –
                        recommendations

Boggi, Ugo; Vistoli, Fabio; Andrès, Axel; Arbogast, Helmut; Badet, Lionel; Baronti, Walter; Bartlett, Stephen T.; Benedetti, Enrico; Branchereau, J.; Burke, George W.; Buron, Fanny; Caldara, Rossana; Cardillo, Massimo; Casanova, Daniel; Cipriani, Francesco; Cooper, Matthew; Cupisti, Adamasco; Davide, Josè; Drachenberg, Cinthia B.; Koning, Eelco J.P. de; Ettorre, Giuseppe Maria; Cruz, Laureano Fernández; Fridell, Jonathan A.; Friend, Peter J.; Furian, Lucrezia; Gaber, Osama; Gruessner, Angelika C.; Gruessner, Rainer W.G.; Gunton, Jenny E.; Han, Duck Jong; Iacopi, Sara; Kauffmann, Emanuele Federico; Kaufman, Dixon B.; Kenmochi, Takashi; Khambalia, Hussein; Lai, Quirino; Langer, Róbert; Maffi, Paola; Marselli, Lorella; Menichetti, Francesco; Miccoli, Mario; Mittal, Shruti; Morélon, Emmanuel; Napoli, Niccolò; Neri, Flavia; Oberholzer, José; Odorico, Jon S.; Öllinger, Robert; Oniscu, Gabriel C.; Orlando, Giuseppe; Ortenzi, Monica; Perosa, Marcelo; Perrone, Vittorio; Pleass, Henry; Redfield, Robert; Ricci, Claudio; Rigotti, Paolo; Robertson, R. Paul; Ross, Lainie Friedman; Rossi, Massimo; Saudek, František; Scalea, Joseph R.; Schenker, Peter; Secchi, Antonio; Socci, C.; Silva, Donzília Sousa; Squifflet, Jean; Stock, Peter G.; Stratta, Robert J.; Terrenzio, Chiara; Uva, Pablo; Watson, Christopher J.; White, Steven A.; Marchetti, Piero; Kandaswamy, Raja; Berney, Thierry

doi:10.1111/ajt.16750

Cited by 56 publications

(39 citation statements)

References 385 publications

(957 reference statements)

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“…Although vascular thrombosis has been shown to be a risk factor for graft loss ( 28 - 34 ), in this series no differences have been observed in relation to the preservation solution used. The same applies to intestinal-related morbidity.…”

Section: Discussionmentioning

confidence: 53%

Current Trends in Organ Preservation Solutions for Pancreas Transplantation: A Single-Center Retrospective Study

et al. 2022

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Due to the high vulnerability of the pancreas to ischemia-reperfusion injury, choices regarding preservation solution markedly affect pancreas transplant success. A retrospective single-center analysis of 380 pancreas transplants (2000–2019) was performed to correlate current preservation solutions with transplant outcomes. Early graft failure requiring transplantectomy within 30 days post-transplant occurred in 7.5% for University of Wisconsin (UW) group (n = 267), 10.8% of Celsior (CS) group (n = 83), 28.5% of Histidine-Tryptophan-Ketoglutarate (HTK) group (n = 7), and none for Institut Georges Lopez-1 (IGL-1) group (n = 23). The most common causes of technical failures in this cohort included abdominal hemorrhage (8.4%); graft pancreatitis (3.7%); fluid collections (2.6%); intestinal complications (6.6%); and vascular thrombosis (20.5%). Although IGL-1 solution provided lower surgical complication rates, no significant differences were found between studied groups. Nevertheless, HTK solution was associated with elevated pancreatitis rates. The best graft survival was achieved at 1 year using UW and IGL-1, and at 3 and 5 years using IGL-1 (p = 0.017). There were no significant differences in patient survival after a median follow-up of 118.4 months. In this setting therefore, IGL-1 solution appears promising for perfusion and organ preservation in clinical pancreas transplantation, compared to other commonly used solutions.

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Section: Discussionmentioning

confidence: 53%

Current Trends in Organ Preservation Solutions for Pancreas Transplantation: A Single-Center Retrospective Study

et al. 2022

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“…1 The preservation solution HTK has been highlighted as a risk factor for graft pancreatitis. 1,8 However, the first world consensus on pancreas transplantation recognizes that HTK could be used at low perfusion volumes when cold ischemia time is >10 h. 9 The use of HTK as a perfusion solution remains popular because of its lower cost.…”

Section: Discussionmentioning

confidence: 99%

Salvage of Graft Pancreas in a Simultaneous Pancreas-kidney Transplant Recipient With Splenic Artery Thrombosis, Infected Walled-off Necrosis, and Stenting of Y Arterial Graft Stenosis

Choudhary

Vijayvergiya

Sharma

et al. 2022

Transplantation Direct

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“…Pancreas transplantation is a preferential option for patients with type 1 diabetes mellitus in order to improve their quality of life and survival. 1 This procedure is usually reserved to those diabetic patients that develop end-stage renal disease (ESRD) and require simultaneous kidney transplantation, or to those that have previously undergo kidney transplantation, although it has been also recently recommended as single organ transplantation. 1 As other types of solid organ transplantation (SOT), pancreas transplant recipients (PTRs) face an increased risk of infectious complications due the effect of long-term immunosuppression.…”

Section: Introductionmentioning

confidence: 99%

“…1 This procedure is usually reserved to those diabetic patients that develop end-stage renal disease (ESRD) and require simultaneous kidney transplantation, or to those that have previously undergo kidney transplantation, although it has been also recently recommended as single organ transplantation. 1 As other types of solid organ transplantation (SOT), pancreas transplant recipients (PTRs) face an increased risk of infectious complications due the effect of long-term immunosuppression. Posttransplant infection constitutes a relevant cause of morbidity and mortality in this population.…”

Section: Introductionmentioning

confidence: 99%

Fluconazole versus micafungin for initial antifungal prophylaxis against Candida in pancreas transplant recipients: A comparative study of two consecutive periods

López‐Medrano

Espada

Asín

et al. 2022

Mycoses

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Background: Invasive fungal infection, particularly intraabdominal candidiasis, exerts a negative impact on the outcome of pancreas transplant recipients (PTRs). Optimal antifungal prophylaxis in this context remains unclear. Methods:We performed a single-centre retrospective study to compare the incidence of invasive candidiasis during the first 6 post-transplant months in a cohort of 218 PTRs over two periods in which different agents for antifungal prophylaxis were

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First World Consensus Conference on pancreas transplantation: Part II – recommendations

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri butio n-NonCo mmerc ial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Cited by 56 publications

References 385 publications

Current Trends in Organ Preservation Solutions for Pancreas Transplantation: A Single-Center Retrospective Study

Current Trends in Organ Preservation Solutions for Pancreas Transplantation: A Single-Center Retrospective Study

Salvage of Graft Pancreas in a Simultaneous Pancreas-kidney Transplant Recipient With Splenic Artery Thrombosis, Infected Walled-off Necrosis, and Stenting of Y Arterial Graft Stenosis

Fluconazole versus micafungin for initial antifungal prophylaxis against Candida in pancreas transplant recipients: A comparative study of two consecutive periods

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