Converging hazard assessment of gold nanoparticles to aquatic organisms

García-Cambero, Jesús Pablo; García, Mercedes Núñez; López, Gema Díaz; Herranz, A. López; Cuevas, Laureano; Pérez-Pastrana, Esperanza; Cuadal, Judith Sendra; Castelltort, Marc Ramis; Calvo, Argelia Castaño

doi:10.1016/j.chemosphere.2013.06.074

Cited by 36 publications

(15 citation statements)

References 25 publications

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“…(2013) 72 observed the uptake of gold NPs in vivo with minimal evidence of AuNPs ability to cross the Daphnia magna digestive tract. However, these studies were not focused on positivelycharged particles, which have a greater potential to be further incorporated into the organism.…”

Section: Discussionmentioning

confidence: 99%

Surface chemistry, charge and ligand type impact the toxicity of gold nanoparticles to Daphnia magna

Bozich

Lohse

Torelli

et al. 2014

Environ. Sci.: Nano

139

114

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Section: Discussionmentioning

confidence: 99%

Surface chemistry, charge and ligand type impact the toxicity of gold nanoparticles to Daphnia magna

Bozich

Lohse

Torelli

et al. 2014

Environ. Sci.: Nano

139

114

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“…Two types of singular NMs that have been a prominent focus of study in aquatic toxicology are metal- and carbon-based NMs. For metals, most studies have focused on TiO 2 [ 190 ], Ag [ 191 ], ZnO [ 31 ] and CuO [ 192 ] nanoparticles, with a smaller subset examining quantum dots [ 193 ], Al [ 194 ], Ni [ 195 ], Ce [ 196 ], Fe [ 197 ] and Au [ 198 ] particles. The carbonaceous materials primarily investigated include multiple types of carbon nanotubes ( i.e.…”

Section: Toxicological Implications For Nhs Based On Current Biolomentioning

confidence: 99%

Emergent Properties and Toxicological Considerations for Nanohybrid Materials in Aquatic Systems

et al. 2014

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Conjugation of multiple nanomaterials has become the focus of recent materials development. This new material class is commonly known as nanohybrids or "horizon nanomaterials". Conjugation of metal/metal oxides with carbonaceous nanomaterials and overcoating or doping of one metal with another have been pursued to enhance material performance and/or incorporate multifunctionality into nano-enabled devices and processes. Nanohybrids are already at use in commercialized energy, electronics and medical products, which warrant immediate attention for their safety evaluation. These conjugated ensembles likely present a new set of physicochemical properties that are unique to their individual component attributes, hence increasing uncertainty in their risk evaluation. Established toxicological testing strategies and enumerated underlying mechanisms will thus need to be re-evaluated for the assessment of these horizon materials. This review will present a critical discussion on the altered physicochemical properties of nanohybrids and analyze the validity of existing nanotoxicology data against these unique properties. The article will also propose strategies to evaluate the conjugate materials' safety to help undertake future toxicological research on the nanohybrid material class.

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“…Data demonstrated that AuNP were detected in tissues of Daphnia magna fed with the unicellular microorganisms Chlamydomonas reinhardtii and Euglena gracilis previously exposed to these MNM (Lee et al, 2015). Gold nanoparticles were shown to accumulate in the digestive tract of both aquatic invertebrates and fish following exposure to concentrations from 0.5 to 100 mg/L and 20 mg/L, respectively; however, no apparent adverse effects were observed (Botha et al, 2016;García-Cambero et al, 2013). In contrast, adverse effects of AuNP on aquatic organisms were reported (Pan et al, 2012;Teles et al, 2016).…”

Section: Introductionmentioning

confidence: 97%

Gold nanorods induce early embryonic developmental delay and lethality in zebrafish (Danio rerio)

Mesquita

Lopes²,

Silva

et al. 2017

Journal of Toxicology and Environmental Health, Part A

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Due to their unique electronic and optical features, gold nanoparticles (AuNP) have received a great deal of attention for application in different fields such as catalysis, electronics, and biomedicine. The large-volume manufacturing predicted for future decades and the inevitable release of these substances into the environment necessitated an assessment of potential adverse human and ecological risks due to exposure to AuNP. Accordingly, this study aimed to examine the acute and developmental toxicity attributed to a commercial suspension of Au nanorods stabilized with cetyltrimethylammonium bromide (CTAB-AuNR) using early embryonic stages of zebrafish (Danio rerio), a well-established model in ecotoxicology. Zebrafish embryos were exposed to CTAB-AuNR (0-150 µg/L) to determine for developmental assessment until 96 hr post fertilization (hpf) and lethality. Uptake of CTAB-AuNR by embryos and nanoparticles potential to induce DNA damage was also measured at 48 and 96 hpf. Analysis of the concentration-response curves with cumulative mortality at 96 hpf revealed a median lethal concentration (LC) of 110.2 μg/L. At sublethal concentrations, CTAB-AuNR suspensions were found to produce developmental abnormalities such as tail deformities, pericardial edema, decreased body length, and delayed eye, head, and tail elongation development. Further, less than 1% of the initial concentration of CTAB-AuNR present in the exposure media was internalized by zebrafish embryos prior to (48 hpf) and after hatching (96 hpf). In addition, no marked DNA damage was detected in embryos after exposure to CTAB-AuNR. Overall, CTAB-AuNR suspensions produced lethal and sublethal effects on zebrafish embryos with possible repercussions in fitness of adult stages. However, these results foresee a low risk for fish since the observed effects occurred at concentrations above the levels expected to find in the aquatic environment.

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Converging hazard assessment of gold nanoparticles to aquatic organisms

Cited by 36 publications

References 25 publications

Surface chemistry, charge and ligand type impact the toxicity of gold nanoparticles to Daphnia magna

Surface chemistry, charge and ligand type impact the toxicity of gold nanoparticles to Daphnia magna

Emergent Properties and Toxicological Considerations for Nanohybrid Materials in Aquatic Systems

Gold nanorods induce early embryonic developmental delay and lethality in zebrafish (Danio rerio)

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