“…For instance, Swi2/Snf2-related 1 (SWR1) complex replaces the histone H2A with the histone variant H2A.Z to maintain the suppression of several SA-dependent defense genes ( March-Diaz et al, 2008 ). These genes include CLASSY1 (CLSY1), which is implicated in the RdDM pathway, is required for accumulation of hc-siRNA, and interacts with H3K9 methylation ( Luna and Ton, 2012 ; Zhang et al, 2013 ; Zhou et al, 2018 ), as well as DDM1, which is required for DNA methylation and regulates expression of NLRs ( Jeddeloh et al, 1998 , 1999 ; Stokes et al, 2002 ; Li et al, 2010 ; Cambiagno et al, 2021 ). In addition, the expression of NLR SNC1 is suppressed by SPLAYED (SYD), another SWI2/SNF2-like ATPase, which is confirmed by the elevated transcription in the syd mutant.…”