Controversies in acute kidney injury: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference

Ostermann, Marlies; Bellomo, Rinaldo; Burdmann, Emmanuel A.; Doi, Kent; Endre, Z. H.; Goldstein, Stuart L.; Kane‐Gill, Sandra L.; Liu, Kathleen D.; Prowle, John R.; Shaw, Andrew; Srisawat, Nattachai; Cheung, Michael; Jadoul, Michel; Winkelmayer, Wolfgang C.; Kellum, John A.; Bagshaw, Sean M.; Barreto, Erin F.; Bïhorac, Azra; Bobek, Ilona; Bouchard, Josée; Cerdá, Jorge; Chakravarthi, Rajasekara; Rosa, Silvia De; Engelman, Daniel; Forni, Lui G.; Hemmilä, Ulla; Herzog, Charles A.; Hoste, Eric A. J.; Huen, Sarah C.; Iseki, Kunitoshi; Joannidis, Michael; Kashani, Kianoush; Koyner, Jay L.; Kribben, Andreas; Lameire, Norbert; Levey, Andrew S.; Macedo, Etienne; Małyszko, Jolanta; Meersch, Melanie; Mehta, Ravindra L.; Mewburn, Irene; Mironova, Olga Iu.; Murray, Patrick; Nadim, Mitra K.; Pan, Jenny Szu-Chin; Pannu, Neesh; Peng, Zhiyong; Philips, Barbara J.; Ponce, Daniela; Ray, Patricio E.; Ricci, Zaccaria; Rimmelé, Thomas; Ronco, Claudio; Siew, Edward D.; Stevens, Paul E.; Tolwani, Ashita J.; Tonelli, Marcello; Vaara, Suvi T.; Dam, Marjel van; Vijayan, Anitha; Wise, Michael G.; Wu, Vin Cent; Zarbock, Alexander

doi:10.1016/j.kint.2020.04.020

Cited by 278 publications

(186 citation statements)

References 153 publications

(179 reference statements)

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“…Acute kidney injury was defined according to KDIGO, as an increase in serum creatinine of ≥0.3 mg/dl (26.5 μmol/l) during hospitalization 45 . Hypophosphatemia was defined as serum phosphate level <0.81 mmol/l and hypouricemia as a serum uric acid level below 2.5 mg/dl.…”

Section: Methodsmentioning

confidence: 99%

“…44 Acute kidney injury was defined according to Kidney Disease: Improving Global Outcomes (KDIGO), as an increase in serum creatinine of $0.3 mg/dl (26.5 mmol/l) during hospitalization. 45 Hypophosphatemia was defined as a serum phosphate level <0.81 mmol/l, and hypouricemia as a serum uric acid level below 2.5 mg/ dl. Inappropriate uricosuria and phosphaturia were defined as fractional excretion (FE) of uric acid >10% in patients with hypouricemia, or fractional excretion of phosphate (FE PO4 ) >20% in those with hypophosphatemia.…”

Section: Data Collection and Definitionsmentioning

confidence: 99%

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SARS-CoV-2 causes a specific dysfunction of the kidney proximal tubule

Wérion

Belkhir

Perrot

et al. 2020

Kidney International

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Section: Methodsmentioning

confidence: 99%

Section: Data Collection and Definitionsmentioning

confidence: 99%

SARS-CoV-2 causes a specific dysfunction of the kidney proximal tubule

Wérion

Belkhir

Perrot

et al. 2020

Kidney International

Self Cite

189

151

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show abstract

“…11 AKI was defined as an increase in serum creatinine to ≥1.5 times baseline, which is known or presumed to have occurred within the prior 7 days. 12 Oxaluria was reported as urinary oxalate-to-creatinine ratio. 4 , 13 Fecal acid steatocrit was recorded when available.…”

Section: Methodsmentioning

confidence: 99%

Etiologies, Clinical Features, and Outcome of Oxalate Nephropathy

Buysschaert

Aydın

Morelle

et al. 2020

Kidney International Reports

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Background: Oxalate nephropathy is a potentially underestimated cause of kidney failure characterized by massive deposition of calcium oxalate crystals in the renal parenchyma. The prevalence and modes of presentation of this entity are ill-defined. Methods: Here we report on the largest consecutive series of cases of adult oxalate nephropathy diagnosed on native kidney biopsies from January 2010 to December 2018 in the UCLouvain Kidney Disease Network. Results: We screened 2265 native kidney biopsies and identified 22 cases (1%) of oxalate nephropathy. Patients had a mean age at diagnosis of 61 years (AE20) and presented either with acute on chronic kidney disease (CKD) (62%) or with acute kidney injury (AKI) (38%). Mean serum creatinine at biopsy was 8.0 AE 4.5 mg/dl. Kidney biopsies showed abundant calcium oxalate crystal deposits, associated with acute interstitial nephritis and tubular necrosis, and variable degrees of interstitial fibrosis and tubular atrophy. Chronic pancreatitis and gastric bypass were the most common causes of oxalate nephropathy (48%). During a mean follow-up of 29 months, half of the patients (52%) progressed to kidney failure, all within the month following diagnosis. Higher serum creatinine level at presentation and interstitial fibrosis and tubular atrophy score were associated with progression to kidney failure. Conclusion: Oxalate nephropathy is the cause of kidney disease in 1% of consecutive native kidney biopsies and typically presents as acute on CKD or AKI. The prognosis of the disease is poor, with a high rate of kidney failure within the first month after the diagnosis.

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“…4 The KDIGO definition for AKI diagnosis has been adopted as a consensus established by experts worldwide. 4,13 Despite this, many Brazilian intensive care physicians continue to adopt other guidelines. 13 The incidence of AKI (21.3%) and mortality (25.7 %) in our study is in line with the meta-analysis conducted by the Acute Kidney Injury Advisory Group of the American Society of Nephrology, 4 with incidence and mortality of 21.6 and 23.9%, respectively.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological profile of acute kidney injury in critically ill patients admitted to intensive care units: A Prospective Brazilian Cohort

et al. 2021

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Introduction Acute kidney injury (AKI) is a frequent syndrome affecting patients admitted to intensive care units (ICU), and it is associated with poor clinical outcomes. The aim of the present study was to understand the epidemiological profile of patients with AKI admitted to ICUs. Methods Prospective cohort study, carried out in three ICUs in the Federal District, Brazil. Between October/2017 and December/2018, 8,131 patients were included in the cohort. AKI was defined according to the KDIGO criteria. The main outcomes assessed were AKI development and mortality within 28 days of hospitalization. Results Of the 8,131 patients followed up, 1,728 developed AKI (21.3%). Of the 1,728 patients with AKI, 1,060 (61.3%) developed stage 1, while stages 2 and 3 represented 154 (8.9%) and 514 (29.7%), respectively. Of these, 459 (26.6%) underwent renal replacement therapy. The mortality was 25.7% for those with AKI, and 4.9% for those without AKI. Discussion Patients with AKI had higher mortality rates when compared to those without AKI. Likewise, among patients with AKI, higher disease stages were associated with higher death occurrences. AKI incidence (21.3%) and mortality (25.7%) in our study is in line with the largest meta-analysis ever conducted, in which incidence and mortality of 21.6 and 23.9% were observed, respectively. These findings confirm the importance of establishing the KDIGO guideline for the definition and management of AKI in Brazilian ICUs.

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Controversies in acute kidney injury: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference

Cited by 278 publications

References 153 publications

SARS-CoV-2 causes a specific dysfunction of the kidney proximal tubule

SARS-CoV-2 causes a specific dysfunction of the kidney proximal tubule

Etiologies, Clinical Features, and Outcome of Oxalate Nephropathy

Epidemiological profile of acute kidney injury in critically ill patients admitted to intensive care units: A Prospective Brazilian Cohort

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