Controlling transmembrane ion transport via photo-regulated carrier mobility

Abstract

Stimuli-responsive transmembrane ion carriers allow for targeted and controllable transport activity, with potential applications as therapeutics for channelopathies and cancer, and in fundamental studies into ion transport phenomena. These applications...

Stimulus-Controlled Anion Binding and Transport by Synthetic Receptors

“…The group of Manna later designed bis-urea pro-carriers 84a – d (Figure ), which similarly could be deprotected using GSH, as well as by reactive oxygen species (ROS). Furthermore, owing to the nitro substituent in ortho -position to the benzyl sulfonium group, irradiation with UV light additionally caused bond cleavage, somewhat similar to the photocleavable transporters reported by Talukdar and Langton . Deprotection in the presence of GSH and ROS, as followed by HPLC analysis, took 72 and 12 h, respectively, whereas photocleavage using 365 nm light was completed in 10 min in DMSO.…”

Light-Driven Photoconversion of Squaramides with Implications in Anion Transport

“…In MeOH and water solutions, AD-squaramide photodegradation also occurs, likely due to the nucleophilic nature of those solvents. Our findings should be considered in future research involving irradiation of squaramide-containing compounds, for example, in photocatalysis, photoswitchable binding, and transport studies . Moreover, the photodegradation of squaramides which are used in supramolecular catalysis and anion transport offers a new way of regulating both processes.…”

“…Our findings should be considered in future research involving irradiation of squaramide-containing compounds, for example, in photocatalysis, photoswitchable binding, and transport studies. 39 Moreover, the photodegradation of squaramides which are used in supramolecular catalysis and anion transport offers a new way of regulating both processes. As proof of concept, we present the efficient in situ light-induced deactivation of a squaramide-based anion transporter.…”

Progress and prospects toward supramolecular bioactive ion transporters

“…Recently, highly selective methods, including stimuli-responsive protransporters, have been developed by several research groups including us to achieve control over the locus of action of the anionophores. 61,79,85,[87][88][89][90][91][92][93][94][95][96][97][98][99][100] Taken together, synthetic ion transport systems undoubtedly possess immense potential to be used as therapeutic agents in curing life-threatening diseases like cystic fibrosis and cancer. This field has grown rapidly, and new systems with improved efficiencies have recently been reported.…”

“…Recently, highly selective methods, including stimuli-responsive protransporters, have been developed by several research groups including us to achieve control over the locus of action of the anionophores. 61,79,85,87–100…”