Progress and prospects toward supramolecular bioactive ion transporters

Mondal, Abhishek; Ahmad, Manzoor; Mondal, Debashis; Talukdar, Pinaki

doi:10.1039/d2cc06761g

Cited by 10 publications

(9 citation statements)

References 173 publications

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“…Previous reports from our group and others , have demonstrated that disruption of cellular Cl – ion homeostasis is associated with the induction of apoptotic pathways in cells. To gain further insights into the cytotoxicity mediated by 1c , the mitochondrial membrane potential (MMP) was monitored in MDA-MB-231 cells using the JC-1 dye.…”

Section: Resultsmentioning

confidence: 99%

A Benzohydrazide-Based Artificial Ion Channel that Modulates Chloride Ion Concentration in Cancer Cells and Induces Apoptosis by Disruption of Autophagy

et al. 2023

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Fluctuations in the intracellular chloride ion concentration, mediated by synthetic ion transporters, have been known to induce cytotoxicity in cells by disrupting ionic homeostasis. However, the activity of these transporters in modulating autophagy remains largely unexplored. Here, we report a benzoylbenzohydrazide (1c) that self-assembles to form a supramolecular nanochannel lumen that allows selective and efficient transport of chloride ions across the cell membranes, disrupts ion homeostasis, and thus leads to the induction of apoptosis in cancer cells. It is important to note that the transporter was relatively nontoxic to cells of noncancerous origin. 1c was also shown to induce the deacidification of lysosomes, thereby disrupting autophagy in cancer cells. Taken together, these findings provide a rare example of an artificial ion channel that specifically targets cancer cells by induction of apoptosis via disruption of autophagy.

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Section: Resultsmentioning

confidence: 99%

A Benzohydrazide-Based Artificial Ion Channel that Modulates Chloride Ion Concentration in Cancer Cells and Induces Apoptosis by Disruption of Autophagy

et al. 2023

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“…Selective recognition of ionic guests using synthetic molecular receptors has long attracted immense research interest for their significance and diverse applications in controlling ion transport in biological systems, [1][2][3][4] developing sensing and delivery agents for ionic species of environmental, diagnostic and therapeutic significance, [5][6][7][8][9][10][11][12][13] extracting and refining harmful and/or precious ionic components from waste and natural resources, etc. [14][15][16][17] Over the years, tremendous efforts have been devoted in the development of mono-, di-and multitopic molecular hosts for binding various ionic guests, [18][19][20][21][22][23][24][25][26][27] and recent studies have also been extended to responsive hosts featuring switchable ion binding ability.…”

Section: Introductionmentioning

confidence: 99%

Dynamic mechanostereochemical switching of a co-conformationally flexible [2]catenane controlled by specific ionic guests

Yao

Tse

Lai

et al. 2023

Preprint

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Responsive synthetic receptors for adaptive recognition of different ionic guests in a competitive environment are valuable molecular tools for not only ion sensing and transport, but also the development of ion-responsive smart materials and related technologies. By virtue of the mechanical chelation and ability to undergo large-amplitude co-conformational changes, described herein is the discovery of a chameleon-like [2]catenane that selectively binds copper(I) or sulfate ions and its associated co-conformational mechanostereochemical switching. This work highlights not only the advantages and versatility of catenane as a molecular skeleton in receptor design, but also its potential in constructing complex responsive systems with multiple inputs and outputs.

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“…1,2 More recently, the development of anion-selective ionophores, anionophores, has attracted renewed interest. [3][4][5] In particular, potential applications of these compounds as antimicrobial, antiparasitic or anticancer agents have been reported. [6][7][8][9][10] Applications as transmembrane protein surrogates as potential candidates for the treatment of diseases caused by defective transmembrane anion transport, like cystic fibrosis, have also been explored.…”

Section: Introductionmentioning

confidence: 99%

Formulation and evaluation of anion transporters in nanostructured lipid carriers

Alonso-Carrillo,

Carreira-Barral,

Mielczarek

et al. 2023

Org. Biomol. Chem.

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Progress and prospects toward supramolecular bioactive ion transporters

Abstract: The majority of cellular physiological processes depend on natural ion channels, which are pore-forming membrane-embedded proteins that let ions flow across the cell membranes selectively. This selective movement of ions...

Cited by 10 publications

References 173 publications

A Benzohydrazide-Based Artificial Ion Channel that Modulates Chloride Ion Concentration in Cancer Cells and Induces Apoptosis by Disruption of Autophagy

A Benzohydrazide-Based Artificial Ion Channel that Modulates Chloride Ion Concentration in Cancer Cells and Induces Apoptosis by Disruption of Autophagy

Dynamic mechanostereochemical switching of a co-conformationally flexible [2]catenane controlled by specific ionic guests

Formulation and evaluation of anion transporters in nanostructured lipid carriers

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