Controlling the vasculature: Angiogenesis, anti-angiogenesis and vascular targeting of gene therapy

Fan, Tai-Ping; Jagger, Rhys T.; Bicknell, Roy

doi:10.1016/s0165-6147(00)88979-8

Cited by 185 publications

(144 citation statements)

References 52 publications

Supporting

Mentioning

143

Contrasting

Unclassified

Order By: Relevance

“…Angiogenesis is normally a strictly controlled process in the human body. Pathological, unregulated angiogenesis occurs in cancers 98 . Among the angiogenesis inhibitors quercetin seems to play an important role 99 .…”

mentioning

confidence: 99%

Quercetin: A Versatile Flavonoid

Lakhanpal

Kumar²

2007

Internet Journal of Medical Update - EJOURNAL

210

198

View full text Add to dashboard Cite

Associative evidence from observational and intervention studies in human subjects shows that a diet including plant foods (particularly fruit and vegetables rich in antioxidants) conveys health benefits. There is no evidence that any particular nutrient or class of bioactive substances makes a special contribution to these benefits. Flavonoids occur naturally in fruits, vegetables and beverages such as tea and wine. Quercetin is the major flavonoid which belongs to the class called flavonols. Quercetin is found in many common foods including apples, tea, onions, nuts, berries, cauliflower, cabbage and many other foods. Quercetin provides many health promoting benefits, including improvement of cardiovascular health, eye diseases, allergic disorders, arthritis, reducing risk for cancers and many more. The main aim of this review is to obtain a further understanding of the reported beneficial health effects of Quercetin, its pharmacological effects, clinical application and also to evaluate its safety.

show abstract

mentioning

confidence: 99%

Quercetin: A Versatile Flavonoid

Lakhanpal

Kumar²

2007

Internet Journal of Medical Update - EJOURNAL

210

198

View full text Add to dashboard Cite

show abstract

“…Also in that issue of the Proceedings, Goldman et al (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14), they reveal the emergence of a new branch of gene therapy directed at tumor angiogenesis. Of Ϸ200 gene therapy clinical trials, at least 50% are for the treatment of cancer, and virtually all of these strategies target the cancer cell.…”

mentioning

confidence: 99%

Antiangiogenic gene therapy

Folkman

1998

Proc. Natl. Acad. Sci. U.S.A.

182

View full text Add to dashboard Cite

“…Our studies add to these features that medaka embryos are useful for screening anti-cancer drugs, because retinoids are effective chemopreventive agents against many forms of cancer (Hansen et al, 2000;Zusi et al, 2002), and because several anti-angiogenic drugs (inhibitory to blood vessel formation) are currently undergoing clinical trials for the treatment of cancer (Fan et al, 1995;Tosetti et al, 2002). Blood vessels form through a complex process involving multiple steps and several cell types.…”

Section: Screening Anti-cancer Drugs Using Medaka Embryosmentioning

confidence: 82%