Controlling the surface enhanced Raman effect via the nanoshell geometry

Jackson, J. B.; Westcott, Sarah L.; Hirsch, Leon; West, Jennifer L.; Halas, Naomi J.

doi:10.1063/1.1534916

Cited by 400 publications

(320 citation statements)

References 15 publications

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“…Nanoshells have been previously shown to provide significant SERS enhancements of 10 6 -10 10 in the near IR by tuning the plasmon resonance to the excitation laser wavelength [48][49][50]. Additionally, by controlling the geometry of the nanoshells, the SERS enhancement for a layer of nonresonant molecules bound to the surface of the nanoshells can be controlled with quantitative agreement between theoretical and experimental results [48]. Solutions of nanoshells are limited by significant reabsorption of the backscattered SERS signal by other nanoshells, which limits the observed SERS enhancement [49].…”

Section: Introductionmentioning

confidence: 99%

“…Nanoshells are spherical nanoparticles with a dielectric core surrounded by a metal shell with plasmon resonances that can be adjusted by altering the ratio of the core diameter to the shell diameter [47]. Nanoshells have been previously shown to provide significant SERS enhancements of 10 6 -10 10 in the near IR by tuning the plasmon resonance to the excitation laser wavelength [48][49][50]. Additionally, by controlling the geometry of the nanoshells, the SERS enhancement for a layer of nonresonant molecules bound to the surface of the nanoshells can be controlled with quantitative agreement between theoretical and experimental results [48].…”

Section: Introductionmentioning

confidence: 99%

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Application of Surface-Enhanced Raman Spectroscopy for Detection of Beta Amyloid Using Nanoshells

et al. 2007

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Currently, no methods exist for the definitive diagnosis of AD premortem. β-amyloid, the primary component of the senile plaques found in patients with this disease, is believed to play a role in its neurotoxicity. We are developing a nanoshell substrate, functionalized with sialic acid residues to mimic neuron cell surfaces, for the surface-enhanced Raman detection of β-amyloid. It is our hope that this sensing mechanism will be able to detect the toxic form of β-amyloid, with structural and concentration information, to aid in the diagnosis of AD and provide insight into the relationship between β-amyloid and disease progression. We have been successfully able to functionalize the nanoshells with the sialic acid residues to allow for the specific binding of β-amyloid to the substrate. We have also shown that a surface-enhanced Raman spectroscopy response using nanoshells is stable and concentrationdependent with detection into the picomolar range.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Application of Surface-Enhanced Raman Spectroscopy for Detection of Beta Amyloid Using Nanoshells

et al. 2007

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“…Among various metal oxides, MgO is a functional semiconductor which has multiple applications in drug delivery (Seferos and Giljohann 2007), optoelectronics (Jackson et al 2003), cell signalling and imaging (Parak et al 2005) especially as successful potent antimicrobial and antioxidant agents fighting against most provocating antibiotic resistant dreadful diseases (Stoimenov et al 2002;Nasibulin et al 2009;Zhang et al 2012). In the current study, we have employed the plant mediated production of MgO nanoparticles through calcination.…”

Section: Introductionmentioning

confidence: 99%

Facile approach to synthesize magnesium oxide nanoparticles by using Clitoria ternatea—characterization and in vitro antioxidant studies

et al. 2015

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Facile approach to synthesize the metal oxide nanoparticles is getting an increased attention in various biomedical applications such as, to treat antibiotic resistant diseases. Magnesium oxide nanoparticles (MgOÁNPs) were synthesized by using Clitoria ternatea as the stabilizer in a green synthesis approach. The preliminary screening of MgOÁNPs in the presence of C. ternatea extract was observed by UV-visible spectrophotometer. X-ray diffraction (XRD) pattern have proved the crystalline nature of the MgOÁNPs; Photoluminescence (PL) measurement studies are used to identify the quality and defects in the crystal structure. FE-SEM with EDS has showed the size of 50-400 nm with specific binding energies. FT-IR has revealed the functional groups present in the plant extract and the peak at 521 cm -1 indicated the characteristic absorption bands of MgOÁNPs. The DPPH activity and reducing power assay of biologically synthesized MgOÁNPs could reach 65 % at a concentration of 150 lg/ml, respectively. From the results it was concluded that the biologically synthesized MgOÁNPs exhibit good antioxidant activity.

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“…As the aspect ratio increases, the HGNs will absorb longer wavelengths of light [66,83,118,119]. For a fixed core diameter, decreasing the volume of the gold salt delivered produces a thinner shell and red-shifted absorption whereas a constant shell thickness and a decreasing core diameter produce blue-shifted SPR [66,83,120,121].…”

Section: Tuning Lspr To the Nirmentioning

confidence: 99%

Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

2016

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By electrodeposition and galvanic replacement reaction, we developed a facile, time-saving, cost-effective, and environmentally friendly, two-step synthesis route to obtain a controllable cobalt oxide/Au hierarchically nanostructured electrode for glucose sensing. The nanomaterials were characterized by transmission electron microscopy, scanning electron microscopy, Raman spectroscopy, energy-dispersive spectrometry, and X-ray photoelectron spectroscopy, meanwhile, the sensing performance was investigated by cyclic voltammetry and amperometric response. The results revealed that this novel electrode exhibited excellent electrocatalytic performance toward glucose oxidation, with a wide double-linear range from 0.2 μM to 20 mM and a low detection limit of 0.1 μM based on a signal-to-noise ratio of 3, which was mainly attributed to the ability of loading a small amount of Au with good electron conductivity on the surface of cobalt oxide nanosheets with large active surface area and synergistic electrocatalytic activity of Au and cobalt oxide toward glucose electrooxidation. This facile, sensitive, and selective glucose sensor is also proven to be suitable for the detection of glucose in human serum.

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Controlling the surface enhanced Raman effect via the nanoshell geometry

Cited by 400 publications

References 15 publications

Application of Surface-Enhanced Raman Spectroscopy for Detection of Beta Amyloid Using Nanoshells

Application of Surface-Enhanced Raman Spectroscopy for Detection of Beta Amyloid Using Nanoshells

Facile approach to synthesize magnesium oxide nanoparticles by using Clitoria ternatea—characterization and in vitro antioxidant studies

Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

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