Controlling the size and swellability of stimuli-responsive polyvinylpyrrolidone–poly(acrylic acid) nanogels synthesized by gamma radiation-induced template polymerization

Poly(vinylpyrrolidone) – A Versatile Polymer for Biomedical and Beyond Medical Applications

“…That kind of PVP/PAAc hydrogels are of interest as chemical sensors [31,33] , pHcontrolled drug delivery systems [34] , ocular drug solutions [25] , etc.…”

“…Hydrogel nanoparticles are of great interest since they can be obtained in tunable sizes, large surface area, stable interior network structure, and rapid feedback to environmental stimuli, such as ionic strength, pH, and temperature [31,32] . Abd El-Rehim et al reported the fabrication of pH-sensitive PVP/PAAc hydrogel nanoparticles of narrow size distribution by gamma radiation-induced polymerization of acrylic acid (AAc) in an aqueous solution of PVP as a template polymer [31] .…”

“…Hydrogel nanoparticles are of great interest since they can be obtained in tunable sizes, large surface area, stable interior network structure, and rapid feedback to environmental stimuli, such as ionic strength, pH, and temperature [31,32] . Abd El-Rehim et al reported the fabrication of pH-sensitive PVP/PAAc hydrogel nanoparticles of narrow size distribution by gamma radiation-induced polymerization of acrylic acid (AAc) in an aqueous solution of PVP as a template polymer [31] . The authors reported that the controllable sizes of PVP/PAAc nanogels make them useful in drug delivery and bio-imaging, and the existence of carboxylic groups enables the particles to adsorb cationic drugs or to be conjugated with some bioactive molecules [31] .…”

Gamma ray-induced synthesis of hyaluronic acid/chondroitin sulfate-based hydrogels for biomedical applications

“…Also, the radiolysis of Contents lists available at ScienceDirect journal homepage: www.elsevier.com/locate/radphyschem water molecules results in the formation of hydroxyl radicals, which also attack the polymer chains, resulting in the formation of macro-radicals. The recombination of the macro-radicals on different chains results in the formation of covalent bonds, so finally, a cross-linked structure is formed (Abd El-Rehim et al, 2013;Abd Alla. et al, 2012;Magda et al, 2014).…”

Preparation of Poly Acrylic Acid-Poly Acrylamide Composite Nanogels by Radiation Technique

“…12 Ionizing radiation, such as gamma radiation, has been applied for the cross-linking of polymers by the different research groups. 13,14 The advantage of this method is the ability for scaling up and the absence of both potentially toxic monomers and cross-linking agents. The only necessary materials are polymer molecules and water.…”