Controlling Particle Size and Release Kinetics in the Sustained Delivery of Oral Antibiotics Using pH-Independent Mucoadhesive Polymers

Yus, Cristina; Irusta, Silvia; Sebastián, Víctor; Arruebo, Manuel

doi:10.1021/acs.molpharmaceut.0c00408

Cited by 11 publications

(11 citation statements)

References 54 publications

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“… Poly(lactic-co-glycolic acid) Docetaxel Lymphatic absorption 129 42. Chitosan and Eudragit L-100 Insulin Oral insulin delivery system 130 43. Acrylic acid and methacrylic Rifampicin Sustained release and mucoadhesive delivery 131 44.…”

Section: Enteric-coated Nanoparticle Formulations For Non-colorectal mentioning

confidence: 99%

<p>Enteric-Coated Strategies in Colorectal Cancer Nanoparticle Drug Delivery System</p>

Wathoni

Nguyen

Rusdin

et al. 2020

DDDT

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Colorectal cancer is one of the most common cancer diseases with the increase of cases prevalence >5% every year. Multidrug resistance mechanisms and non-localized therapy become primary problems of chemotherapy drugs for curing colorectal cancer disease. Therefore, the enteric-coated nanoparticle system has been studied and proved to be able to resolve those problems with good performance for colorectal cancer. The highlight of our review aims to summarize and discuss the enteric-coated nanoparticle drug delivery system specific for colorectal cancer disease. The main and supporting literatures were collected from published research articles of journals indexed in Scopus and PubMed databases. In the oral route of administration, Eudragit pH-sensitive copolymer as a coating agent prevents the degradation of the nanoparticle system from the gastric fluid and releases drug to intestinal-colon track. Therefore, it provides a colon-specific targeting ability. Impressively, enteric-coated nanoparticles having a sustained release profile significantly increase the cytotoxic effect of chemotherapeutic drugs and achieve cell-specific target delivery. The enteric-coated nanoparticle drug delivery system represents an excellent modification to improve the effectiveness and performance of anticancer drugs for colorectal cancer disease in terms of the oral route of administration.

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Section: Enteric-coated Nanoparticle Formulations For Non-colorectal mentioning

confidence: 99%

<p>Enteric-Coated Strategies in Colorectal Cancer Nanoparticle Drug Delivery System</p>

Wathoni

Nguyen

Rusdin

et al. 2020

DDDT

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“…For each residence time, two aqueous/organic solution phase ratios, 60:40 and 80:20, were evaluated according to the turbidity curve registered by nanoprecipitation (Figure S3, Supporting Information). Considering that the nanoprecipitation process is highly sensitive to the concentration profiles localized in the reaction media, [28,38] the mixing time of the organic and aqueous miscible streams should be as short as possible to promote a fast nucleation and growth of PEG-b-PDAP NPs. The slit interdigital micromixer selected to achieve a molecular mixing of reagents is able to control the efficient mixing of reagents by the shear stress generated at the fluid-fluid interphase and channel-fluid interphase.…”

Section: Self-assembly On Peg-b-pdap By Microfluidics In Watermentioning

confidence: 99%

“…However, it is important to consider that the aim is to translate the production of polymeric vectors from lab to market and simple systems should be used to ease their operation by nonskilled users. As a result, interdigital micromixers were demonstrated to achieve an excellent control [12,27,28] in nanovector specifications while maintaining a production rate as high as 10 g h −1 .…”

Section: Introductionmentioning

confidence: 99%

Microfluidic Synthesis of Block Copolymer Micelles: Application as Drug Nanocarriers and as Photothermal Transductors When Loading Pd Nanosheets

Abad

Mendoza

Usón

et al. 2022

Macromolecular Bioscience

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The synthesis of polymeric nanoparticles from a block copolymer based on poly(ethylene glycol) and a polymethacrylate containing the nucleobase analog 2,6‐diacylaminopyridine is optimized by microfluidics to obtain homogeneous spherical micelles. Loading and delivery properties are studied using naproxen as a model. The incorporation of a Pd precursor in the polymer organic solution fed into the micromixer allows the preparation of Pd(II) precursor‐polymer hybrid systems and the subsequent reduction with CO leads to the in situ synthesis of Pd nanosheets inside of the hydrophobic core of the polymeric micelles. This methodology is highly efficient to yield all polymeric nanoparticles loaded with Pd nanosheets as detected by electron microscopy and energy‐dispersive X‐ray spectroscopy. The cell viability of these Pd nanosheets‐containing polymeric nanoparticles is evaluated using five cell lines, showing a high cytocompatibility at the tested concentrations without detrimental effects in cell membrane and nuclei. Furthermore, the use of these hybrid polymeric nanoparticles as photothermal transductors is evaluated using near infrared as irradiation source as well as its application in photothermal therapy using different cell lines demonstrating a high efficiency in all cell cultures.

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“…Complex size can impact myriad aspects of delivery, such as cellular internalization mechanism, endosomal escape, intracellular trafficking, and complex dissociation kinetics. [55][56][57][58][59][60] Thus, the use of longer PTDMs offers a convenient method for limiting the size of protein nanoparticles as well as boosting the IA of the delivered cargo.…”

Section: Papermentioning

confidence: 99%

Increased block copolymer length improves intracellular availability of protein cargo

et al. 2022

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Controlling Particle Size and Release Kinetics in the Sustained Delivery of Oral Antibiotics Using pH-Independent Mucoadhesive Polymers

Abstract: Copolymers synthesized from acrylic acid and methacrylic acid used as gastroprotective and mucoadhesive enteric coatings have been used to prepare micro (~2 µm),

Cited by 11 publications

References 54 publications

<p>Enteric-Coated Strategies in Colorectal Cancer Nanoparticle Drug Delivery System</p>

<p>Enteric-Coated Strategies in Colorectal Cancer Nanoparticle Drug Delivery System</p>

Microfluidic Synthesis of Block Copolymer Micelles: Application as Drug Nanocarriers and as Photothermal Transductors When Loading Pd Nanosheets

Increased block copolymer length improves intracellular availability of protein cargo

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