Controlling Bioprocesses with Inorganic Surfaces:  Layered Clay Hemostatic Agents

Baker, Sarah E.; Sawvel, April M.; Stucky, Galen D.

doi:10.1021/cm071457b

Cited by 102 publications

(111 citation statements)

References 24 publications

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“…This has been confirmed using TEG, a method that has been used to characterize various aluminosilicate materials for hemostasis [18]. It should be noted that the observed hemostatic effects of all agents, could not be attributed to an increase in blood viscosity, because in a control study where no calcium was added, no coagulation effects (i.e., no changes in blood viscosity) were observed in terms of R, α and MA values.…”

Section: Discussionsupporting

confidence: 53%

Comparative Study of Hemostatic Agents Using Thrombelastography

Peng¹

2016

Mater. Sci. Eng. Adv. Res

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Hemorrhage is one of the leading causes of death in civilian and military trauma. Thrombelastography (TEG) quantitatively measures the viscoelastic changes of whole blood during clotting, from the beginning of coagulation to the end with fibrinolysis. In this study, we successfully developedand used a TEG method to compare a well-known Chinese herb medicine (i.e., Yunnan Baiyao) for hemorrhage control with other commercial hemostatic products (e.g., Celox TM and QuikClot TM ) and chitosan in the form of dry powder or dispersion. When tested in the powder form, the herbal material outperformed Celox TM as indicated by all three TEG parameters (i.e., reaction time R, clot formation rate α and maximum clot strength MA), and was comparable with QuikClot TM , but showed no exothermic effects. When tested in the dispersion form, which may be easier to use (as a spray) than in the powder form, the herbal material provided better hemostasis than the other materials, where the coagulation actions of the latter were reduced in the dispersion form. In addition, comparison among Celox TM and various types of chitosan showed the effects of physical and chemical properties of the chitosan-based biomaterials on hemostasis. The hemostatic mechanisms of these agents and their potential benefitsas an inexpensive, safe, and easily available material for hemorrhage control are discussed.

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Section: Discussionsupporting

confidence: 53%

Comparative Study of Hemostatic Agents Using Thrombelastography

Peng¹

2016

Mater. Sci. Eng. Adv. Res

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“…However, it has been suggested that the modification introduced in the Mt changes substantially its behavior in the experimental model (Maisanaba et al, 2014a). Baker et al (2007) reported that the changes in clay structure and surface property may alter their response to blood-clotting. Therefore, it seems that the organo-modifiers used are the responsible for the higher toxic effects observed in the endothelial cells.…”

Section: Tablementioning

confidence: 99%

Cytotoxicity and mutagenicity assessment of organomodified clays potentially used in food packaging

Maisanaba

Prieto

Pichardo

et al. 2015

Toxicology in Vitro

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“…Desenvolvimentos recentes sobre as argilas têm ampliado sua aplicação além das convencionais como nanocompósitos, adsorventes e catalisadores. Novas aplicações para argilas têm avançado para muitas aplicações biomédicas incluindo sistemas de liberação controlada de drogas, agentes hemostáticos e agente antibacteriano, sendo concluído que a MMT pode ser considerada segura para uma infinidade de aplicações [3][4][5][6][7] . [10] .…”

Section: Introductionunclassified

Viabilidade celular de nanofibras de polímeros biodegradáveis e seus nanocompósitos com argila montmorilonita

Góes¹,

Carvalho²,

Oréfice³

et al. 2012

Polímeros

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Resumo: Mantas não tecidas de nanofibras de três polímeros biodegradáveis poli(ácido láctico), PDLLA, poli(ε-caprolactona), PCL, e poli(butileno adipato-co-tereftalato), PBAT e seus nanocompósitos com uma nanoargila montmorilonita (MMT) foram produzidas por eletrofiação. A morfologia, o comportamento térmico e a estrutura interna das nanofibras foram analisados por microscopia eletrônica de varredura e transmissão, calorimetria diferencial de varredura e difração de raios X, respectivamente. Observou-se que as nanofibras dos nanocompósitos possuíam diâmetros menores do que os correspondentes polímeros puros e que as nanofibras de PBAT puro e de PBAT/MMT apresentavam a menor cristalinidade de todas as mantas. A viabilidade celular de todas as nanofibras foi analisada pela técnica de redução do sal de tetrazolium pelo complexo enzimático piruvato desidrogenase presente na matriz de mitocôndrias (teste MTT). Os resultados mostraram que nenhuma manta nanofibrílica apresentou toxicidade às células e que as nanofibras de PBAT puro e seu nanocompósito propiciaram ainda um ambiente mais favorável ao desenvolvimento celular de fibroblastos de cardiomiócitos do que as condições oferecidas pelo controles, provavelmente por apresentarem menores diâmetros e baixa cristalinidade em relação às demais nanofibras. Estes resultados mostram o potencial de uso destas mantas nanofibrílicas como suportes de crescimento celular. Palavras-chave: Viabilidade celular, nanofibras, eletrofiação, nanocompósitos, polímeros biodegradáveis. Cell Viability of Nanofibers from Biodegradable Polymers and their Nanocomposites with MontmorilloniteAbstract: Non-woven mats of nanofibers of three biodegradable polymers, viz. poly(lactic acid), PDLLA, poly(ε-caprolactone), PCL, and poly(butylene adipate-co-terephthalate), PBAT, and their nanocomposites with montmorillonite nanoclay (MMT) were produced by electrospinning. The morphology, thermal behavior and internal structure of the nanofibers were analyzed by scanning and transmission electron microscopy, differential scanning calorimetry and wide angle X-ray diffraction, respectively. The nanofibers of the nanocomposites had lower diameters than the nanofibers of the corresponding neat polymers, while the nanofibers from PBAT and PBAT/MMT were the least crystalline. The cell viability of all the nanofibers was analyzed by reduction of the tetrazolium salt by the pyruvate dehydrogenase enzymatic complex present in the mitochondria (MTT test). None of the nanofibers was toxic to the cells and the PBAT and PBAT/MMT nanofibers exhibited a more favorable environment for developing fibroblasts from cardiomyocytes than the control, probably due to their low crystallinity. These results demonstrated the potential use of nanofibers´ mats as scaffolds for cell growth. Keywords: Cell viability, nanofibers, electrospinning, nanocomposites, biodegradable polymers. IntroduçãoNanofibras de polímeros podem ser facilmente produzidas pelo processo de eletrofiação, desde que os polímeros tenham uma boa solubilidade em s...

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Controlling Bioprocesses with Inorganic Surfaces: Layered Clay Hemostatic Agents

Cited by 102 publications

References 24 publications

Comparative Study of Hemostatic Agents Using Thrombelastography

Comparative Study of Hemostatic Agents Using Thrombelastography

Cytotoxicity and mutagenicity assessment of organomodified clays potentially used in food packaging

Viabilidade celular de nanofibras de polímeros biodegradáveis e seus nanocompósitos com argila montmorilonita

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