Controlled Trapping of Onion-Like Carbon (OLC) via Dielectrophoresis

Olariu, Marius; Arcire, Alexandru; Płońska‐Brzezińska, Marta E.

doi:10.1007/s11664-016-4870-1

Cited by 11 publications

(4 citation statements)

References 19 publications

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“…This is done, for instance, in the device for the separation of circulating tumor cells from whole blood presented in ref. 15 or in a recent report on the separation of onion-like carbon 16 . The micro electrodes employed in such devices are usually in the same size range as the particles to be separated.…”

Section: Introductionmentioning

confidence: 99%

Bridging the scales in high-throughput dielectrophoretic (bio-)particle separation in porous media

Pesch

Lorenz

Sachdev

et al. 2018

Sci Rep

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Dielectrophoresis (DEP) is a versatile technique for the solution of difficult (bio-)particle separation tasks based on size and material. Particle motion by DEP requires a highly inhomogeneous electric field. Thus, the throughput of classical DEP devices is limited by restrictions on the channel size to achieve large enough gradients. Here, we investigate dielectrophoretic filtration, in which channel size and separation performance are decoupled because particles are trapped at induced field maxima in a porous separation matrix. By simulating microfluidic model porous media, we derive design rules for DEP filters and verify them using model particles (polystyrene) and biological cells (S. cerevisiae, yeast). Further, we bridge the throughput gap by separating yeast in an alumina sponge and show that the design rules are equally applicable in real porous media at high throughput. While maintaining almost 100% efficiency, we process up to 9 mL min−1, several orders of magnitude more than most state-of-the-art DEP applications. Our microfluidic approach provides new insight into trapping dynamics in porous media, which even can be applied in real sponges. These results pave the way toward high-throughput retention, which is capable of solving existing problems such as cell separation in liquid biopsy or precious metal recovery.

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Section: Introductionmentioning

confidence: 99%

Bridging the scales in high-throughput dielectrophoretic (bio-)particle separation in porous media

Pesch

Lorenz

Sachdev

et al. 2018

Sci Rep

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show abstract

“…In addition to the medical applications, DEP has also been widely used in other industrial applications, such as separating minerals (Ballantyne and Holtham, 2010;Ballantyne and Holtham, 2014;Olariu et al, 2017), self-recovering current limiting fuse (Ohtsuka et al, 2006), depositing a patterned coating of a nanostructure material onto a substrate (Pethig, 2010;Froude and Zhu, 2009), collecting of micron-scale particles (granular, threadlike, sheets, or microelectronic parts) (Pethig, 2010;Allahrabbi et al, 2015), polishing local areas of 3D surfaces using abrasive powders (Pethig, 2010;Kim et al, 2004), biodegradation of organic pollutants in soil (Pethig, 2010;Luo et al, 2005), and in water treatments systems (Pethig, 2010;Abbasi Monfared et al, 2018). During the separating of minerals, DEP is applied at different frequencies and based on the frequency, the polarizability of the mineral particles' changes.…”

Section: Dielectrophoresis: Utility Of Electric Fields To Detect Circ...mentioning

confidence: 99%

Recent progress in microRNA detection using integrated electric fields and optical detection methods

Velmanickam,

Nawarathna

2024

Front. Lab. Chip. Technol.

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Low-cost, highly-sensitivity, and minimally invasive tests for the detection and monitoring of life-threatening diseases and disorders can reduce the worldwide disease burden. Despite a number of interdisciplinary research efforts, there are still challenges remaining to be addressed, so clinically significant amounts of relevant biomarkers in body fluids can be detected with low assay cost, high sensitivity, and speed at point-of-care settings. Although the conventional proteomic technologies have shown promise, their ability to detect all levels of disease progression from early to advanced stages is limited to a limited number of diseases. One potential avenue for early diagnosis is microRNA (miRNA). Due to their upstream positions in regulatory cascades, blood-based miRNAs are sensitive biomarkers that are detectable earlier than those targeted by other methods. Therefore, miRNA is a promising diagnostic biomarker for many diseases, including those lacking optimal diagnostic tools. Electric fields have been utilized to develop various biomedical assays including cell separation, molecules detection and analysis. Recently, there has been a great interest in the utility of electric fields with optical detection methods, including fluorescence and surface plasmons toward biomarker detection. This mini review first summarizes the recent development of miRNA as a biomarker. Second, the utility of electric fields and their integration with fluorescence detection methods will be discussed. Next, recent studies that utilized electric fields and optical detection methods will be discussed. Finally, in conclusion, technology gaps and improvements needed to enable low-cost and sensitive biomarker detection in point-of-care settings will be discussed.

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“…Herein, oxidised boron-nitrogen codoped carbon nano-onions (oxi-BNCNO) and electrochemically synthesised microscale branched copper clusters (CuC/oxi-BNCNO) were explored as electrocatalysts in the preparation of an electrochemical sensor for the determination of EFV in wastewater and pharmaceutical formulations. The interest in the zerodimensional, quasi-spherical and polyhedral fullerene-like carbon nano-onions arises due to their high electrical conductivity (≈ 71.8 µS), catalytic activity, large surface area, resistance to corrosion, low cytotoxicity, and their ability to form composites with other materials [29][30][31][32][33][34][35][36][37][38]. In addition, copper and its oxides have gained prominence as electrocatalysts in sensor fabrication due to their natural abundance, ease of preparation, relatively low cost, excellent electrical conductivity and electrocatalytic activity, large surface area and good reproducibility [39][40][41][42].…”

Section: Introductionmentioning

confidence: 99%

Copper-Modified Carbon Nano-Onions as Electrode Modifiers for the Electroanalysis of the Antiretroviral Drug Efavirenz

Mokwebo

Murphy

Guin

et al. 2023

Preprint

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Controlled Trapping of Onion-Like Carbon (OLC) via Dielectrophoresis

Cited by 11 publications

References 19 publications

Bridging the scales in high-throughput dielectrophoretic (bio-)particle separation in porous media

Bridging the scales in high-throughput dielectrophoretic (bio-)particle separation in porous media

Recent progress in microRNA detection using integrated electric fields and optical detection methods

Copper-Modified Carbon Nano-Onions as Electrode Modifiers for the Electroanalysis of the Antiretroviral Drug Efavirenz

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