Controlled synthesis of calcium carbonate nanoparticles and stimuli-responsive multi-layered nanocapsules for oral drug delivery

Elbaz, Nancy M.; Owen, Andrew; Rannard, Steve; McDonald, Tom O.

doi:10.1016/j.ijpharm.2019.118866

Cited by 48 publications

(37 citation statements)

References 46 publications

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“…Metallic materials such as iron oxide [ 78 ] and gold [ 33 , 47 ] spheres were used as template core and are able to be removed by hydrochloric acid solution or potassium cyanide solution after polysaccharide shell is formed. Calcium carbonate as an inorganic candidate template core of nanocapsules can be removed by adding ethylene diamine tetra acetic acid into a nanocapsule water dispersion at pH 7 [ 79 ]. In addition, silica is another inorganic material generally used as template core and removable by complete dissolution in hydrofluoric acid [ 80 ].…”

Section: Current Status Of Nanocapsules: Materials and Formulationmentioning

confidence: 99%

“…A pH-responsive multilayer prepared by LBL methods was developed which was composed of four polyelectrolytes: poly-L-arginine, sodium alginate, chitosan and Eudragit L100. When using chitosan as outer layer, the nanocapsules showed a desirable delay of drug release at pH 1.2, while, a promising sustained release at pH 7.4 due to the protonated and deprotonated effect of chitosan at pH 1.2 and 7.4, respectively [ 79 ]. It has been demonstrated that this pH-sensitive nanocapsule can be considered as potential drug delivery system to achieve intestine targeting via oral administration.…”

Section: Current Status Of Nanocapsules: Materials and Formulationmentioning

confidence: 99%

“…A kind of multilayer nanocapsule—fabricated by a layer-by-layer method—has been developed and has achieved intestine release via oral administration [ 79 ]. The payload was successfully protected against degradation in the first part of digestive system via nanocapsule encapsulation.…”

Section: Highlighted Applications Of Nanocapsules As Drug Deliverymentioning

confidence: 99%

See 2 more Smart Citations

Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

et al. 2020

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Polymer-based nanocapsules have been widely studied as a potential drug delivery system in recent years. Nanocapsules—as one of kind nanoparticle—provide a unique nanostructure, consisting of a liquid/solid core with a polymeric shell. This is of increasing interest in drug delivery applications. In this review, nanocapsules delivery systems studied in last decade are reviewed, along with nanocapsule formulation, characterizations of physical/chemical/biologic properties and applications. Furthermore, the challenges and opportunities of nanocapsules applications are also proposed.

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Section: Current Status Of Nanocapsules: Materials and Formulationmentioning

confidence: 99%

Section: Current Status Of Nanocapsules: Materials and Formulationmentioning

confidence: 99%

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Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

et al. 2020

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“…The templating synthesis is commonly used as it allows the preparation of capsules of finely tuned properties, various compositions and morphologies, modified release kinetics, and controlled size [ 31 ]. The use of solid colloidal templates (e.g., polystyrene, calcium carbonate, silica) led to the formation of monodisperse carriers of well-defined properties [ 38 , 39 , 40 , 41 ]. Despite many desirable features, the fabrication of capsules templated on hard colloidal cores is not free from limitations.…”

Section: Fabrication Of Polymer Core-shell Nanocapsulesmentioning

confidence: 99%

Polymer Capsules with Hydrophobic Liquid Cores as Functional Nanocarriers

et al. 2020

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Recent developments in the fabrication of core-shell polymer nanocapsules, as well as their current and future applications, are reported here. Special attention is paid to the newly introduced surfactant-free fabrication method of aqueous dispersions of nanocapsules with hydrophobic liquid cores stabilized by amphiphilic copolymers. Various approaches to the efficient stabilization of such vehicles, tailoring their cores and shells for the fabrication of multifunctional, navigable nanocarriers and/or nanoreactors useful in various fields, are discussed. The emphasis is placed on biomedical applications of polymer nanocapsules, including the delivery of poorly soluble active compounds and contrast agents, as well as their use as theranostic platforms. Other methods of fabrication of polymer-based nanocapsules are briefly presented and compared in the context of their biomedical applications.

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“…However, the difficultly to obtain non-aggregated and monodisperse crystals is still pronounced. Experimental conditions, such as the concentration of the respective precursor salts, the pH, the agitation time and speed, and the temperature, can affect the final crystal size and morphology [ 150 , 151 , 152 , 153 ], as illustrated in Figure 5 B. For instance, if precursor salt concentrations are increased whilst the remaining parameters remain constant, smaller vaterite crystals will be produced.…”

Section: The Fabrication Of Pemc Structuresmentioning

confidence: 99%

Polyelectrolyte Multilayer Capsule (PEMC)-Based Scaffolds for Tissue Engineering

et al. 2020

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Tissue engineering (TE) is a highly multidisciplinary field that focuses on novel regenerative treatments and seeks to tackle problems relating to tissue growth both in vitro and in vivo. These issues currently involve the replacement and regeneration of defective tissues, as well as drug testing and other related bioapplications. The key approach in TE is to employ artificial structures (scaffolds) to support tissue development; these constructs should be capable of hosting, protecting and releasing bioactives that guide cellular behaviour. A straightforward approach to integrating bioactives into the scaffolds is discussed utilising polyelectrolyte multilayer capsules (PEMCs). Herein, this review illustrates the recent progress in the use of CaCO3 vaterite-templated PEMCs for the fabrication of functional scaffolds for TE applications, including bone TE as one of the main targets of PEMCs. Approaches for PEMC integration into scaffolds is addressed, taking into account the formulation, advantages, and disadvantages of such PEMCs, together with future perspectives of such architectures.

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Controlled synthesis of calcium carbonate nanoparticles and stimuli-responsive multi-layered nanocapsules for oral drug delivery

Cited by 48 publications

References 46 publications

Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

Polymer Capsules with Hydrophobic Liquid Cores as Functional Nanocarriers

Polyelectrolyte Multilayer Capsule (PEMC)-Based Scaffolds for Tissue Engineering

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