Polymer Capsules with Hydrophobic Liquid Cores as Functional Nanocarriers

Szafraniec-Szczęsny, Joanna; Janik-Hazuka, Małgorzata; Odrobińska, Joanna; Zapotoczny, Szczepan

doi:10.3390/polym12091999

Cited by 28 publications

(19 citation statements)

References 207 publications

(232 reference statements)

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“…Our previous works demonstrated that HyC12-based nanocapsules with liquid hydrophobic cores represent a promising and tunable nanodelivery system for lipophilic active compounds via both, oral and intravenous, administration in vivo. 28 , 29 Interestingly, our in vitro studies revealed that nanocapsules were taken up by mouse liver sinusoidal endothelial cells and lung vascular endothelial cells, suggesting their possible application as a hydrophobic drug delivery system targeted to the vascular wall. 28 Moreover, we showed also the potential for the delivery of lipophilic compounds due to their high stability and efficient uptake by various cells, especially the ones exposing CD44 receptors.…”

Section: Introductionmentioning

confidence: 86%

Low Dose Curcumin Administered in Hyaluronic Acid-Based Nanocapsules Induces Hypotensive Effect in Hypertensive Rats

Czyżyńska-Cichoń¹,

Janik-Hazuka²,

Szafraniec-Szczęsny³

et al. 2021

IJN

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Background Vascular drug delivery becomes a promising direction in the development of novel therapeutic strategies in the treatment of cardiovascular pathologies, such as hypertension. However, targeted delivery of hydrophobic substances, with poor bioavailability, remains a challenge. Here, we described the hypotensive effects of a low dose of curcumin delivered to the vascular wall using hyaluronic acid-based nanocapsules. Methods The group of hypertensive TGR(m-Ren2)27 rats, was administrated respectively with the vehicle, curcumin solution or curcumin delivered using hyaluronic acid-based nanocapsules (HyC12-Cur), for 7 days each, maintaining the wash-out period between treatments. Arterial blood pressure (systolic - SBP, diastolic – DBP) and heart rate (HR) were monitored continuously using a telemetry system (Data Science International), and Mean Arterial Pressure (MAP) was calculated from SBP and DBP. Results In hypertensive rats, a low dose of curcumin (4.5 mg/kg) administrated in HyC12-Cur for 7 days resulted in a gradual inhibition of SBP, DBP and MAP increase without an effect on HR. At the end of HyC12-Cur – based treatment changes in SBP, DBP and MAP amounted to −2.0±0.8 mmHg, −3.9±0.7 mmHg and −3.3±0.7 mmHg, respectively. In contrast, the administration of a curcumin solution (4.5 mg/kg) did not result in a significant hypotensive effect and the animals constantly developed hypertension. Vascular delivery of capsules with curcumin was confirmed using newly developed fluorine-rich nanocapsules (HyFC10-PFOB) with a shell based on a HA derivative and similar size as HyC12-Cur. HyFC10-PFOB gave fluorine signals in rat aortas analyzed ex vivo with a 19 F NMR technique after a single intragastric administration. Conclusion These results suggest that nanocapsules based on hyaluronic acid, the ubiquitous glycosaminoglycan of the extracellular matrix and an integral part of endothelial glycocalyx, may represent a suitable approach to deliver hydrophobic, poorly bioavailable compounds, to the vascular wall.

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Section: Introductionmentioning

confidence: 86%

Low Dose Curcumin Administered in Hyaluronic Acid-Based Nanocapsules Induces Hypotensive Effect in Hypertensive Rats

Czyżyńska-Cichoń¹,

Janik-Hazuka²,

Szafraniec-Szczęsny³

et al. 2021

IJN

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“…The latest approach is the use of nanocapsules to deliver RIPs to virus-infected cells. Nanocapsules are vesicular objects in which the encapsulated compound is confined in an internal cavity surrounded by an outer membrane [ 182 , 183 ]. Nanocapsules containing MAP30 [ 180 ] or ricin A-chain [ 181 ] have shown antiviral activity in vitro against HIV.…”

Section: Experimental Therapymentioning

confidence: 99%

Antiviral Activity of Ribosome-Inactivating Proteins

Citores

Iglesias

Ferreras

2021

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Ribosome-inactivating proteins (RIPs) are rRNA N-glycosylases from plants (EC 3.2.2.22) that inactivate ribosomes thus inhibiting protein synthesis. The antiviral properties of RIPs have been investigated for more than four decades. However, interest in these proteins is rising due to the emergence of infectious diseases caused by new viruses and the difficulty in treating viral infections. On the other hand, there is a growing need to control crop diseases without resorting to the use of phytosanitary products which are very harmful to the environment and in this respect, RIPs have been shown as a promising tool that can be used to obtain transgenic plants resistant to viruses. The way in which RIPs exert their antiviral effect continues to be the subject of intense research and several mechanisms of action have been proposed. The purpose of this review is to examine the research studies that deal with this matter, placing special emphasis on the most recent findings.

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“…Most studies focused on the molecular effects of these compounds report dissolving DADS [13,14] and DATS [15] in dimethyl sulfoxide (DMSO). However, during the last few decades, there have been an increasing number of works considering the delivery of hydrophobic actives using drug-delivery systems (DDSs) based on, e.g., polymers, including e.g., polysaccharides [16][17][18][19][20], liposomes [21], bilosomes [22]. In particular, the nanoscale systems are of high interest for the encapsulation of hydrophobic pharmaceuticals and nutraceuticals [23][24][25].…”

Section: Introductionmentioning

confidence: 99%

“…To address these challenges, the study presented herein includes the encapsulation of sparingly water soluble natural garlic oil compounds (DADS and DATS) aiming mainly at effectively carrying them in physiological environments and protection against oxidation for safe storage and therapeutic action. The formulation is based on nanocapsules with a hyaluronate shell surrounding liquid oil cores dispersed in an aqueous medium [19,37,38]. The hydrophobically modified natural polysaccharide, the sodium salt of hyaluronic acid (HA), constitutes a shell that stabilizes the nanodroplets by the polymeric hydrophobic chains anchoring in the oil core.…”

Section: Introductionmentioning

confidence: 99%

Hyaluronic Acid-Based Nanocapsules as Efficient Delivery Systems of Garlic Oil Active Components with Anticancer Activity

et al. 2021

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Diallyl disulfide (DADS) and diallyl trisulfide (DATS) are garlic oil compounds exhibiting beneficial healthy properties including anticancer action. However, these compounds are sparingly water-soluble with a limited stability that may imply damage to blood vessels or cells after administration. Thus, their encapsulation in the oil-core nanocapsules based on a derivative of hyaluronic acid was investigated here as a way of protecting against oxidation and undesired interactions with blood and digestive track components. The nuclear magnetic resonance (1H NMR) technique was used to follow the oxidation processes. It was proved that the shell of the capsule acts as a barrier limiting the sulfur oxidation, enhancing the stability of C=C bonds in DADS and DATS. Moreover, it was shown that the encapsulation inhibited the lysis of the red blood cell membrane (mainly for DADS) and interactions with serum or digestive track components. Importantly, the biological functions and anticancer activity of DADS and DATS were preserved after encapsulation. Additionally, the nanocapsule formulations affected the migration of neoplastic cells—a desirable preliminary observation concerning the inhibition of migration. The proposed route of administration of these garlic extract components would enable reaching their higher concentrations in blood, longer circulation in a bloodstream, and thus, imply a better therapeutic effect.

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Polymer Capsules with Hydrophobic Liquid Cores as Functional Nanocarriers

Cited by 28 publications

References 207 publications

Low Dose Curcumin Administered in Hyaluronic Acid-Based Nanocapsules Induces Hypotensive Effect in Hypertensive Rats

Low Dose Curcumin Administered in Hyaluronic Acid-Based Nanocapsules Induces Hypotensive Effect in Hypertensive Rats

Antiviral Activity of Ribosome-Inactivating Proteins

Hyaluronic Acid-Based Nanocapsules as Efficient Delivery Systems of Garlic Oil Active Components with Anticancer Activity

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