Controlled self-assembly of amphiphilic monotailed single-chain nanoparticles

Wen, Jianguo; Zhang, Jing; Zhang, Yue; Yang, Yongfang; Zhao, Hanying

doi:10.1039/c4py00100a

Cited by 41 publications

(44 citation statements)

References 41 publications

(14 reference statements)

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“…The tertiary amine block was cross-linked with 1,4-diiodobutane via the Menschutkin reaction to form "tadpole"-shaped amphiphiles. 52,86 These shape amphiphiles, bearing a hydrophilic SCNP head and a hydrophobic polystyrene tail, were capable of self-assembling into micelles or vesicles based on solvent conditions. The diameters of these micelles were between 30 and 80 nm.…”

Section: ■ the Pressing Challengesmentioning

confidence: 99%

What Is Next in Single-Chain Nanoparticles?

2015

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With the increasing appeal of nanotechnology, there is a demand for development of synthetic techniques for the fabrication of nanosized objects that allow for precise size control and tailored functionalization. To this end, the collapse or folding of single polymer chains into architecturally defined nanostructures is a rapidly growing research topic in polymer science. Many synthetic approaches have been developed for the formation of single-chain nanoparticles (SCNP), and a variety of characterization methods and computational efforts have been utilized to detail their formation and probe their morphological characteristics. Interest in this field continues to grow partially due to the variety of potential applications of SCNP including catalysis, sensors, nanoreactors, and nanomedicine. While numerous developments have been made, the field is continuing to evolve, and there are still many unanswered questions regarding synthesis and characterization of SCNP. This Perspective serves to identify recent accomplishments in the synthesis and characterization of SCNP while distinguishing areas that are in need of advancement and innovation to move forward. This includes exploring more complex synthetic strategies, obtaining folding control, employing nanoparticle functionalization, developing scalable methods, investigating hierarchical self-assembly of SCNP, and exploiting unique characterization techniques and in-depth simulations.

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Section: ■ the Pressing Challengesmentioning

confidence: 99%

What Is Next in Single-Chain Nanoparticles?

2015

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“…In a further study by the same group, 119 the effect of charge density on self-assembly was investigated for PS x -b-PDMAEMA y tadpoles of different block length (x, y = number of PS and PDMAEMA repeat units, respectively). The morphology and the size of the aggregates changed significantly with the charge density.…”

Section: Single Chain Tadpolesmentioning

confidence: 99%

Advances in single chain technology

2015

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The recent ability to manipulate and visualize single atoms at atomic level has given rise to modern bottom-up nanotechnology. Similar exquisite degree of control at the individual polymeric chain level for producing functional soft nanoentities is expected to become a reality in the next few years through the full development of so-called "single chain technology". Ultra-small unimolecular soft nano-objects endowed with useful, autonomous and smart functions are the expected, long-term valuable output of single chain technology. This review covers the recent advances in single chain technology for the construction of soft nano-objects via chain compaction, with an emphasis in dynamic, letter-shaped and compositionally unsymmetrical single rings, complex multi-ring systems, single chain nanoparticles, tadpoles, dumbbells and hairpins, as well as the potential end-use applications of individual soft nano-objects endowed with useful functions in catalysis, sensing, drug delivery and other uses.

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“…By varying the irradiation time of the photo crosslinking and the lengths of the hydrophilic block, a library of different morphologies including vesicles, spheres, tubes, lamellae, doughnuts, and connected spheres was obtained, providing architectural guidelines on how the design of SCNPs controls their self‐assembly. In addition to the degree of folding, the modulation of the charge density of the folded block has shown to affect the morphologies of SCNP assemblies …”

Section: Architecture Beyond Intramolecular Crosslinksmentioning

confidence: 99%

Macromolecular Superstructures: A Future Beyond Single Chain Nanoparticles

Frisch

Tuten

Barner‐Kowollik

2020

Israel Journal of Chemistry

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Over the last 100 years polymer chemistry has flourished in all areas and enabled control over synthetic polymer architectures – including chain lengths, dispersity and monomer sequences. Compared to the architectures of biomacromolecules, these scientific achievements mainly took place on the level of primary structures. The plethora of functions carried out by proteins in nature, however, does not only result from their primary structure, but from its folding into perfectly defined 3D structures. Striving towards a similar architectural control and function in synthetic polymers, the field of single chain nanoparticles (SCNPs) emerged. In this review, we analyze the state of the art and identify what is currently standing between polymer chemistry and perfectly controlled synthetic macromolecular architectures. Based on the current challenges in the field of SCNPs, we discuss potential avenues to break today's barriers and explore future applications reaching beyond the current‐state‐of‐the‐art.

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Controlled self-assembly of amphiphilic monotailed single-chain nanoparticles

Cited by 41 publications

References 41 publications

What Is Next in Single-Chain Nanoparticles?

What Is Next in Single-Chain Nanoparticles?

Advances in single chain technology

Macromolecular Superstructures: A Future Beyond Single Chain Nanoparticles

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