Advances in single chain technology

González-Burgos, Marina; Latorre-Sánchez, Alejandro; Pomposo, José A.

doi:10.1039/c5cs00209e

Cited by 229 publications

(225 citation statements)

References 155 publications

(335 reference statements)

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“…[2][3][4] SCPNs based on synthetic polymers benefit from the possibility of a controlled construction of the precursors in order to prepare tuned SCPNs with desired size and functionality.3 Additionally, a wide variety of biocompatible, non-toxic and ready-to-use natural polymers are available. Consequently, SCPNs have gained interest as potential mimetics of biomacromolecules such as proteins 5,6 and for application in different fields including nanomedicine.…”

Section: Synthesis and Functionalization Of Dextran-based Single-chaimentioning

confidence: 99%

Synthesis and functionalization of dextran-based single-chain nanoparticles in aqueous media

et al. 2017

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Synthesis and Functionalization of Dextran-Based Single-Chain Nanoparticles in Aqueous Media IK4-CIDETEC, Pº Miramón 196, 20014, Donostia-San Sebastián, Spain. b. Radiochemistry and Nuclear Imaging Group, CIC biomaGUNE, Pº Miramón 182, 20014, Donostia-San Sebastián, Spain. Water-dispersible dextran-based single-chain polymer nanoparticles (SCPNs) were prepared in aqueous media and mild conditions. Radiolabeling of the resulting biocompatible materials allowed the study of lung deposition of aqueous aerosols after intratracheal nebulization by means of single-photon emission computed tomography (SPECT), demostrating their potential use as imaging contrast agents.Advances in engineering polymer chains at the molecular level 1 have pushed the development of synthetic strategies for the controlled compaction of single polymer coils into unimolecular soft nano-objects, named single-chain polymer nanoparticles (SCPNs).2-4 SCPNs based on synthetic polymers benefit from the possibility of a controlled construction of the precursors in order to prepare tuned SCPNs with desired size and functionality.3 Additionally, a wide variety of biocompatible, non-toxic and ready-to-use natural polymers are available. Consequently, SCPNs have gained interest as potential mimetics of biomacromolecules such as proteins 5,6 and for application in different fields including nanomedicine.7-9 Among natural polymers, polysaccharides can be envisaged as natural analogues of polyethylene glycol (PEG). For example, dextrans have been used in several biomedical applications due to aqueous solubility, biocompatibility, biodegradability, wide availability, ease of modification and non-fouling properties.10,11 However, in vivo application of SCPNs can be limited due to their small size. Rapid blood clearance is expected after intravenous administration of particles below 5 nm size. 12 In the last years, non-invasive lung administration route has been broadly studied, 13 and SCPNs could be beneficial due to their small size.14 Synthetic routes to SCPNs are mainly based on intrachain homo-and hetero-coupling or cross-linking-induced collapseof pre-functionalized polymers through covalent, dynamic covalent, and non-covalent bonding. 15,16 Most of the covalent strategies are performed in organic solvents and require highly diluted polymer solutions (usually <1 mg/mL), high temperatures and/or the presence of metal catalysts. The preparation of SCPNs through "continuous addition" avoids ultra-dilution conditions, which is beneficial for multigram scale preparations. 17 Recently, it has been described that the presence of oligo(ethylene glycol) brushes as side-chains allows to achieve SCPNs at high polymer concentrations (100 mg/mL). 18 However, the development of general procedures to obtain functionalizable SCPNs in aqueous media, mild conditions and scalable conditions is still a challenging issue.Our group reported a strategy to generate structurally defined and water-dispersible poly(methacrylic acid)-based SCPNs.19 In pursuit of novel types of...

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Section: Synthesis and Functionalization Of Dextran-based Single-chaimentioning

confidence: 99%

Synthesis and functionalization of dextran-based single-chain nanoparticles in aqueous media

et al. 2017

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“…In order to engineering functional soft nanomaterials that closely mimic biomolecules in structure and behaviour, a paradigm in polymer synthesis involves handling single polymer chains 1 . Among the various techniques employed to these ends, the collapse of single polymer chains (precursors) via purely intramolecular cross-linking, into single-chain nanoparticles (SCNPs), has gained increasing interest over recent years [2][3][4][5] . Significant effort is being devoted to endow SCNPs with useful functions for multiple applications in, e.g., nanomedicine, biosensing, bioimaging or catalysis [6][7][8][9][10] .…”

Section: Introductionmentioning

confidence: 99%

Tunable slow dynamics in a new class of soft colloids

et al. 2016

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By means of extensive simulations, we investigate concentrated solutions of globular single-chain nanoparticles (SCNPs), an emergent class of synthetic soft nano-objects. By increasing the concentration, the SCNPs show a reentrant behaviour in their structural and dynamical correlations, as well as a soft caging regime and weak dynamic heterogeneity. The latter is confirmed by validation of the Stokes-Einstein relation up to concentrations far beyond the overlap density. Therefore SCNPs arise as a new class of soft colloids, exhibiting slow dynamics and actualizing in a real system structural and dynamical anomalies proposed by models of ultrasoft particles. Quantitative differences in the dynamical behaviour depend on the SCNP deformability, which can be tuned through the degree of internal cross-linking.

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“…The equations of motion are integrated using the velocity-Verlet algorithm with a time step of ∆t = 0.01τ, following the impulse approach as put forward in, e.g., refs 40 and 41 . The size of our simulation box is V = L 3 = (100σ ) 3 and we run simulations with three different monomer densities ρ = NN c /L 3 = {0.1, 0.2, 0.3}, where N c is the total number of molecules in the system. This range of densities lies well over the overlap density (5-15 times) for both precursor molecules,…”

Section: Model and Simulation Detailsmentioning

confidence: 99%

“…Single-chain nanoparticles (SCNPs) are an emergent class of soft nano-objects of molecular size of 5-20 nm [1][2][3][4][5] . They are synthesized, generally at high dilution (∼ 1 mg/mL), through purely intramolecular cross-linking of the reactive functional groups of single polymer precursors.…”

Section: Introductionmentioning

confidence: 99%

Effects of precursor topology and synthesis under crowding conditions on the structure of single-chain polymer nanoparticles

Formanek

Moreno

2017

Soft Matter

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By means of molecular dynamics simulations we investigate the formation of single-chain nanoparticles through intramolecular cross-linking of polymer chains, in the presence of their precursors acting as purely steric crowders in concentrated solution. In the case of the linear precursors, the structure of the resulting SCNPs is weakly affected by the density at which the synthesis is performed. Crowding has significant effects if ring precursors are used: higher concentrations lead to the formation of SCNPs with more compact and spherical morphologies. Such SCNPs retain in the swollen state (high dilution) the crumpled globular conformations adopted by the ring precursors in the crowded solutions. Increasing the concentration of both the linear and ring precursors up to 30 % leads to faster formation of the respective SCNPs.

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Advances in single chain technology

Cited by 229 publications

References 155 publications

Synthesis and functionalization of dextran-based single-chain nanoparticles in aqueous media

Synthesis and functionalization of dextran-based single-chain nanoparticles in aqueous media

Tunable slow dynamics in a new class of soft colloids

Effects of precursor topology and synthesis under crowding conditions on the structure of single-chain polymer nanoparticles

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