Controlled Release Strategies for the Combination of Fresh and Lyophilized Platelet-Rich Fibrin on Bone Tissue Regeneration

Liu, Zhongshuang; Jin, Han; Xie, Qingguo; Jiang, Zhuling; Guo, Shouli; Liu, Ying; Zhang, Bin

doi:10.1155/2019/4923767

Cited by 19 publications

(18 citation statements)

References 20 publications

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“…Since the primary macrophages of different individuals differed, we did not extract primary cells. Although many literatures have reported the use of i‐PRF to treat cells of heterogeneous origin (Dai et al, ; do Lago, Ferreira, Garcia Jr., Okamoto, & Mariano, ; Kargarpour et al, ; Liu et al, ), this is a limitation of current research. For example, without using primary cells, it may not be possible to accurately simulate the immune response in the body.…”

Section: Discussionmentioning

confidence: 88%

Anti‐inflammation effects of injectable platelet‐rich fibrin via macrophages and dendritic cells

Zhang

Yin

Zhao

et al. 2019

J Biomedical Materials Res

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Immune response to implantation materials plays a critical role during early local inflammation and biomaterial-induced regeneration or restoration. A novel platelet concentrate termed i-PRF (injectable platelet-rich fibrin) has recently been developed without any additives by low centrifugation speeds. To date, scientists have investigated the capability of releasing growth factors to improve regeneration but have ignored whether i-PRF can inhibit the inflammatory effect around the wound. The present study investigated the anti-inflammation effects of i-PRF on immune response-related cells, especially macrophages and dendric cells. We found that i-PRF reduced pro-inflammatory M1 phenotype of macrophages and activated dendritic cells around muscle defect that was injected with bacterial suspension. Moreover, in vitro experiments showed similar results. i-PRF deleted inflammatory response caused by lipopolysaccharide to some extent. We determined that TLR4, an activator of inflammatory stimulation and p-p65, a key factor belongs to classical inflammatory related NF-κB signal pathway, can be inhibited by use of i-PRF. Results indicate the potential anti-inflammatory role of i-PRF during regeneration and restoration.

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Section: Discussionmentioning

confidence: 88%

Anti‐inflammation effects of injectable platelet‐rich fibrin via macrophages and dendritic cells

Zhang

Yin

Zhao

et al. 2019

J Biomedical Materials Res

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“…In another example, FD-PRP was used to enhance the biological activities of fresh PRP formulations. Supplementing fresh PRF with allogeneic FD-PRF increased the concentration of GFs and other signaling cytokines, thereby enhancing bone regeneration in two different rodent calvarial models [66,67].…”

Section: Dentistry Researchmentioning

confidence: 99%

Freeze-Drying of Platelet-Rich Plasma: The Quest for Standardization

Andı́a

Perez‐Valle

Amo

et al. 2020

IJMS

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The complex biology of platelets and their involvement in tissue repair and inflammation have inspired the development of platelet-rich plasma (PRP) therapies for a broad array of medical needs. However, clinical advances are hampered by the fact that PRP products, doses and treatment protocols are far from being standardized. Freeze-drying PRP (FD-PRP) preserves platelet function, cytokine concentration and functionality, and has been proposed as a consistent method for product standardization and fabrication of an off-the-shelf product with improved stability and readiness for future uses. Here, we present the current state of experimental and clinical FD-PRP research in the different medical areas in which PRP has potential to meet prevailing medical needs. A systematic search, according to PRISMA (Preferred Reported Items for Systematic Reviews and Meta-Analyses) guidelines, showed that research is mostly focused on wound healing, i.e., developing combination products for ulcer management. Injectable hydrogels are investigated for lumbar fusion and knee conditions. In dentistry, combination products permit slow kinetics of growth factor release and functionalized membranes for guided bone regeneration.

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“…Recently, L‐GFs have been used in different fields including ophthalmology treating ocular surface disorders, 9 orthopedic surgery for bone tissue regeneration, 10 and in plastic surgery treating chronic wounds 11 as well as acute wounds of burns 12 . It has not been used widely in dermatological fields.…”

Section: Discussionmentioning

confidence: 99%

“…This handling is recommended for facilitating platelets storage, reducing the frequency of its contamination, and increasing the period of its validity. 7,8 Recently, L-GFs have been used in different medical and surgical fields including ophthalmology, 9 orthopedic surgery, 10 and plastic surgery. 11,12 Based on its previously proved efficacy in tissue restoration and healing process, we decided to evaluate its possible therapeutic role in post-acne scars.…”

mentioning

confidence: 99%

Fractional carbon dioxide laser‐assisted delivery of lyophilized‐growth factors is a promising treatment modality of post‐acne scars

Neinaa

Al-Khayat²,

Suliman

et al. 2020

Dermatologic Therapy

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Lyophilized-growth factors (L-GFs), is a new platelet rich plasma (PRP) preparation that is standardized in growth factors concentrations. The aim of this study was to compare the therapeutic efficacy of ablative fractional CO 2 laser in combination with L-GFs vs PRP in post-acne scars. This study was conducted on 45 patients presented with facial post-acne scars. Each patient received three sessions of fractional CO 2 laser on both sides of the face followed by topical application of L-GFs on one side and conventional PRP on the other side. Assessment was done before and after treatment semiquantitatively by Echella d'Èvaluation Clinique des Cicatrices d'Acné (ECCA) score and qualitatively by Goodman and Baron's qualitative scar (GBQS) scale, in addition to dermoscopic evaluation. The current study reported significant clinical improvement of post-acne scars on both sides of the face evidenced by significant reduction of both ECCA score and GBQS scale with minimal side effects. The degree of clinical improvement and patients' satisfaction were significantly higher with shorter downtime in response to fractional CO 2 laser combined with L-GFs rather than its combination with PRP. In conclusion, laser assisted delivery of L-GFs via fractional CO 2 laser could be considered a novel successful therapeutic modality for post-acne scars.

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Controlled Release Strategies for the Combination of Fresh and Lyophilized Platelet-Rich Fibrin on Bone Tissue Regeneration

Cited by 19 publications

References 20 publications

Anti‐inflammation effects of injectable platelet‐rich fibrin via macrophages and dendritic cells

Anti‐inflammation effects of injectable platelet‐rich fibrin via macrophages and dendritic cells

Freeze-Drying of Platelet-Rich Plasma: The Quest for Standardization

Fractional carbon dioxide laser‐assisted delivery of lyophilized‐growth factors is a promising treatment modality of post‐acne scars

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