Controlled-release solid dispersions of Eudragit® FS 100 and poorly soluble spironolactone prepared by electrospinning and melt extrusion

Balogh, Attila; Farkas, Balázs; Domokos, András; Farkas, Attila; Démuth, Balázs; Borbás, Enikő; Nagy, Brigitta; Marosi, György

doi:10.1016/j.eurpolymj.2017.08.032

Cited by 42 publications

(26 citation statements)

References 37 publications

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“…In addition to the conventional use as granules, powders, and aqueous solutions, Eudragit copolymers have been applied as support for electrospinning procedure . The retention in the bioactivity of specific molecules—proteins and drugs (such as spironolactone, budesonide, and indomethacin) in aggressive acidic environments (stomach) and release throughout ileum and colon represent important applications for Eudragit‐based electrospun fibers …”

Section: Introductionmentioning

confidence: 99%

Eudragit E100/poly(ethylene oxide) electrospun fibers for DNA removal from aqueous solution

Barbosa

França

Gouveia

et al. 2019

J of Applied Polymer Sci

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The development of new strategies for production of low‐cost deoxyribonucleic acid (DNA) adsorbents based on electrospun fibers of block copolymers [Eudragit E‐100/poly(ethylene oxide) (PEO)] is a promising way for fast retrieval of free of degradation double‐stranded DNA chains from aqueous solution. The adsorption takes place through electrostatic interaction between DNA and oppositely charged electrospun fibers that provide high surface area for DNA adsorption. The adsorption capacity observed for electrospun fibers of Eudragit E100/PEO (considering as target molecules the salmon sperm DNA) was in order of 44.31 mg g−1, following the Langmuir model in a typical adsorption at solid/liquid interface (pseudo‐second‐order model), that characterizes the electrospun fibers as promising templates for removal of biologic components and further use in molecular biology techniques, as DNA amplification by polymerase chain reaction. The reuse and integrity of membranes after long period of adsorption were tested, confirming the potential of material as adsorbent. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47479.

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Section: Introductionmentioning

confidence: 99%

Eudragit E100/poly(ethylene oxide) electrospun fibers for DNA removal from aqueous solution

Barbosa

França

Gouveia

et al. 2019

J of Applied Polymer Sci

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“…However, the productivity of SNES does not satisfy the pharmaceutical requirements thus scaling-up of the technology is essential. In recent years, many methods have been created for this purpose such as needleless electrospinning [25][26][27][28], multineedle electrospinning [29], alternating current electrospinning [30][31][32], and high-speed electrospinning (HSES) [33]. The latter one, where electrostatic and centrifugal forces are combined, may be a highly suitable technology in the pharmaceutical industry for mass production of fibrous drug delivery systems.…”

mentioning

confidence: 99%

Scaled-up preparation of drug-loaded electrospun polymer fibres and investigation of their continuous processing to tablet form

Szabó

Démuth

Nagy

et al. 2018

Express Polym. Lett.

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“…Among the different kinds of strategies that have been broadly investigated to resolve this problem, drug solid dispersions (SDs) are some of the most promising ways with many commercial products [ 5 , 6 , 7 , 8 , 9 ]. New methods for creating new kinds of high-performance SDs are always desired and are thus becoming a rapidly developing branch of pharmaceutical technologies [ 10 , 11 , 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Fast Dissolving of Ferulic Acid via Electrospun Ternary Amorphous Composites Produced by a Coaxial Process

et al. 2018

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Enhancing the dissolution of insoluble active ingredients comprises one of the most important issues in the pharmaceutical and biomaterial fields. Here, a third generation solid dispersion (3rd SD) of ferulic acid was designed and fabricated by a modified coaxial electrospinning process. A traditional second generation SD (2nd SD) was also prepared by common one-fluid blending electrospinning and was used as a control. With poly(vinyl alcohol) as the fiber matrix and polyvinylpyrrolidone K10 as an additive in the 3rd SDs, the two electrospinning processes were investigated. The prepared 2nd and 3rd SDs were subjected to a series of characterizations, including X-ray diffraction (XRD), scanning electron microscope (SEM), hydrophilicity and in vitro drug dissolving experiments. The results demonstrate that both SDs were monolithic nanocomposites and that the drugs were amorphously distributed within the matrix. However, the 3rd SDs had better morphology with smaller size, narrower size distribution, and smaller water contact angles than the 2nd SDs. Dissolution tests verified that the 3rd SDs could release their loaded cargoes within 60 s, which was over three times faster than the 2nd SDs. Therefore, a combined strategy based on the modified coaxial electrospinning and the logical selections of drug carriers is demonstrated for creating advanced biomaterials.

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Controlled-release solid dispersions of Eudragit® FS 100 and poorly soluble spironolactone prepared by electrospinning and melt extrusion

Cited by 42 publications

References 37 publications

Eudragit E100/poly(ethylene oxide) electrospun fibers for DNA removal from aqueous solution

Eudragit E100/poly(ethylene oxide) electrospun fibers for DNA removal from aqueous solution

Scaled-up preparation of drug-loaded electrospun polymer fibres and investigation of their continuous processing to tablet form

Fast Dissolving of Ferulic Acid via Electrospun Ternary Amorphous Composites Produced by a Coaxial Process

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