Controlled release of vancomycin from thin sol–gel films on titanium alloy fracture plate material

Radin, S.; Ducheyne, Paul

doi:10.1016/j.biomaterials.2006.11.035

Cited by 149 publications

(87 citation statements)

References 21 publications

(42 reference statements)

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“…Specifically, we incorporated the antibiotic vancomycin and the analgesic bupivacaine. The selection of these molecules was related to our parallel programs that focus on osteomyelitis treatment [19] and surgical pain control [20]. Herein, we report on the synthesis parameters of emulsified acid -base catalyzed microspheres that affect optimal controlled release, with optimization being related to achieving release kinetics of vancomycin and bupivacaine with a desirable therapeutic profile.…”

Section: U N C O R R E C T E D P R O O Fmentioning

confidence: 99%

The controlled release of drugs from emulsified, sol gel processed silica microspheres

2009

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Controlled release silica sol gels are room temperature processed, porous, resorbable materials with generally good compatibility. Many molecules including drugs, proteins and growth factors can be released from sol gels and the quantity and duration of the release can vary widely. Processing parameters render these release properties exquisitely versatile. The synthesis of controlled release sol gels typically includes acid catalyzed hydrolysis to form a sol with the molecules included. This is then followed by casting, aging and drying. Additional steps such as grinding and sieving are required to produce sol gel granules of a desirable size. In this study, we focus on the synthesis of sol gel microspheres by using a novel process with only two steps. The novelty is related to acid-base catalysis of the sol prior to emulsification. Sol gel microspheres containing either vancomycin (antibiotic) or bupivacaine (analgesic) were successfully synthesized using this method. Both drugs showed controlled, load dependent and time dependent release from the microspheres. The in vitro release properties of sol gel microspheres were remarkably different from those of sol gel granules produced by grinding and sieving. In contrast to a fast, short-term release from granules, the release from microspheres was slower and of longer duration. In addition, the degradation rate of microspheres was significantly slower than that of the granules. Using various mathematical models, the data reveal that the release from sol gel powder is governed by two distinct phases of release. In addition, the release from emulsified microspheres is delayed, a finding that can be attributed to differences in surface properties of the particles produced by emulsification and those produced by casting and grinding. The presented results represent an excellent data set for designing and implementing preclinical studies. t r a c tControlled release silica sol gels are room temperature processed, porous, resorbable materials with generally good compatibility. Many molecules including drugs, proteins and growth factors can be released from sol gels and the quantity and duration of the release can vary widely. Processing parameters render these release properties exquisitely versatile. The synthesis of controlled release sol gels typically includes acid catalyzed hydrolysis to form a sol with the molecules included. This is then followed by casting, aging and drying. Additional steps such as grinding and sieving are required to produce sol gel granules of a desirable size. In this study, we focus on the synthesis of sol gel microspheres by using a novel process with only two steps. The novelty is related to acid-base catalysis of the sol prior to emulsification. Sol gel microspheres containing either vancomycin (antibiotic) or bupivacaine (analgesic) were successfully synthesized using this method. Both drugs showed controlled, load dependent and time dependent release from the microspheres. The in vitro release properties of sol gel microspher...

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Section: U N C O R R E C T E D P R O O Fmentioning

confidence: 99%

The controlled release of drugs from emulsified, sol gel processed silica microspheres

2009

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“…These materials have many different action mechanisms. Materials can interfere with bacterial adhesion by modifying surface energy 20) and immobilizing molecules onto the surface (bactericidal) 21) , photocatalytic 22) , releasing metal ions 23) or antibiotics 24) . Because of material corrosion, which is usually caused by saliva electrolyte solution and tooth brushing, the function period of the strong and active bactericidal activity of the above materials was short, sometimes only 1 month in vitro 25) .…”

Section: Discussionmentioning

confidence: 99%

The anti-bacterial activity of titanium-copper sintered alloy against <i>Porphyromonas gingivalis</i> <i>in vitro </i>

Bai

Zhang

Liu

et al. 2016

Dental Materials Journal

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This study investigates the anti-bacterial property of Ti-Cu sintered alloys against Porphyromonas gingivalis. The anti-anaerobic property of Ti-Cu sintered alloys against P. gingivalis was investigated by antibacterial activity test, DNA measurement, DAPI staining and morphology observation. The antibacterial rates of the Ti-5Cu against P. gingivalis after 18 and 24 h incubation were 36.04 and 54.39%, and those of Ti-10Cu were 68.69 and 75.39%, which were lower than their anti-aerobic abilities. The concentration of P. gingivalis DNA gradually decreased with the increasing Cu content, which was nearly 50% after 24 h incubation on Ti-10Cu. SEM results showed that the shape of P. gingivalis changed and the bacteria broke apart with the addition of Cu and the extension of the culture time. Ti-Cu sintered alloys could not only kill anaerobic bacteria but also reduce the activity of the survived bacteria. The anti-anaerobic mechanism was thought to be in associated with the Cu ion released from Ti-Cu alloy.

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“…A close correlation between vancomycin release and sol-gel film degradation rates indicated that film degradation is the main mechanism underlying the control of release. 50,51 Polyelectrolyte multilayer materials. Although many antimicrobial orthopedic implant coatings are developed, drug dosage or release rate cannot be easily tuned in most cases.…”

Section: Coating Materialsmentioning

confidence: 99%

Recent advances in materials for extended-release antibiotic delivery system

et al. 2011

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To maintain antimicrobial activity, frequent administration of conventional formulations of many antibiotics with short half-life is necessary. Otherwise, concentration under MIC occurs frequently in the course of anti-infective treatment, which induces antibiotic resistance. By maintaining a constant plasma drug concentration over MIC for a prolonged period, extended-release dosage forms maximize the therapeutic effect of antibiotics while minimizing antibiotic resistance. Another undoubted advantage of extended-release formulation is improved patient compliance. For better release properties, many materials have been introduced into the matrix and coating extended-release system in the past few years. Materials that have been widely used in industry are hydrophilic matrix materials such as hydroxypropylmethylcellulose. The excellent biocompatibility and extensive laboratory studies provide biodegradable polymers great potential for industrial applications. In addition, it seems like the researches on tailored materials that are obtained by chemical modification of the existing materials or combination of different carriers in physical mixtures have a long way to go. Meanwhile, with the development of polymers and inorganic porous nanocarriers, nanotechnology is applied increasingly for the extended delivery of antibiotics. This review highlights the development of materials used in extended-release formulation and nanoparticles for antibiotic delivery. We also provide an overview of the antibiotic extended-release products that have provided clinical benefit or are undergoing the clinical trial.

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Controlled release of vancomycin from thin sol–gel films on titanium alloy fracture plate material

Cited by 149 publications

References 21 publications

The controlled release of drugs from emulsified, sol gel processed silica microspheres

The controlled release of drugs from emulsified, sol gel processed silica microspheres

The anti-bacterial activity of titanium-copper sintered alloy against <i>Porphyromonas gingivalis</i> <i>in vitro </i>

Recent advances in materials for extended-release antibiotic delivery system

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