Controlled Release of the α-Tocopherol-Derived Metabolite α-13′-Carboxychromanol from Bacterial Nanocellulose Wound Cover Improves Wound Healing

Abstract

Inflammation is a hallmark of tissue remodeling during wound healing. The inflammatory response to wounds is tightly controlled and well-coordinated; dysregulation compromises wound healing and causes persistent inflammation. Topical application of natural anti-inflammatory products may improve wound healing, in particular under chronic pathological conditions. The long-chain metabolites of vitamin E (LCM) are bioactive molecules that mediate cellular effects via oxidative stress signaling as well as anti-inflammatory pathways. However, the effect of LCM on wound healing has not been investigated. We administered the α-tocopherol-derived LCMs α-13′-hydroxychromanol (α-13′-OH) and α-13′-carboxychromanol (α-13′-COOH) as well as the natural product garcinoic acid, a δ-tocotrienol derivative, in different pharmaceutical formulations directly to wounds using a splinted wound mouse model to investigate their effects on the wounds’ proinflammatory microenvironment and wound healing. Garcinoic acid and, in particular, α-13′-COOH accelerated wound healing and quality of the newly formed tissue. We next loaded bacterial nanocellulose (BNC), a valuable nanomaterial used as a wound dressing with high potential for drug delivery, with α-13′-COOH. The controlled release of α-13′-COOH using BNC promoted wound healing and wound closure, mainly when a diabetic condition was induced before the injury. This study highlights the potential of α-13′-COOH combined with BNC as a potential active wound dressing for the advanced therapy of skin injuries.

Integrated network pharmacology and experimental validation to explore the mechanisms underlying naringenin treatment of chronic wounds

“…Many natural products with therapeutic potential have been applied in clinical practice and have attracted increasing interest in recent years 23 . Meanwhile, an increasing number of natural products combined with other dressings and agents for the treatment of chronic wounds have achieved satisfactory results 24 , 25 . Naringenin (the chemical structure is shown in Fig.…”

Advances in the Preparation of Nanofiber Dressings by Electrospinning for Promoting Diabetic Wound Healing

“…The main pathological abnormalities in diabetic wounds are vascular problems and long-term inflammatory response, so single-therapy approaches often fail to achieve the desired results. Studies have shown that wound closure is a closely regulated and highly coordinated process between pro- and anti-inflammation [ 45 ]. Therefore, intervention in the healing process to reduce the inflammatory response and stimulate tissue regeneration is currently essential to achieve the faster healing of diabetic wounds [ 46 ].…”

Natural Polysaccharide-Based Nanodrug Delivery Systems for Treatment of Diabetes

“…The results indicated that the NBCH have great potential as an ideal wound dressing for efficient and rapid healing in patients with diabetes. For another example, Adrian T. Press et al [ 106 ] used bacterial nanocelluloses (BNC) as wound dressing to load α -13′-COOH (α-Tocopherol-Derived Metabolite), which was directly applied to wounds using a splinted wound mouse model under the condition of diabetes, to investigate their effects on wounds’ proinflammatory microenvironment and wound healing. The results showed that BNC could control the release of α -13′-COOH and promote wound healing and wound closure.…”