Controlled release of protein drugs from newly developed amphiphilic polymer-based microparticles composed of nanoparticles

Kakizawa, Yasushi; Nishio, Reiji; Hirano, Taisuke; Koshi, Yoichiro; Nukiwa, Mio; Koiwa, Masakazu; Michizoe, Junji; Ida, Nobuo

doi:10.1016/j.jconrel.2009.09.024

Cited by 37 publications

(19 citation statements)

References 26 publications

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“…[1][2][3] Biodegradable polyesters such as poly (lactide-co-glycolide) (PLGA), poly (lactic acid) (PLA) and poly (e-caprolactone) (PCL) have been widely used as carriers in controlled-release delivery systems due to their biocompatibility and biodegradability. 3,4 Their degradation time can be varied from days to years by altering the type of polymer, the polymer molecular weight, or the structure of the microspheres.…”

Section: Introductionmentioning

confidence: 99%

“…Macromolecular drug, as proteins and peptides, were preferred as water-soluble model drug for various microspheres release analysis 2,12 and the two main release mechanisms associated with drug release from PLGA microspheres were thought to be diffusion and degradation/erosion. However, few literatures concentrated on the release kinetics of small water-soluble drugs had been reported, 13 which may different from macromolecular drugs.…”

Section: Introductionmentioning

confidence: 99%

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Effects of drug and polymer molecular weight on drug release from PLGA‐mPEG microspheres

Feng

Nie

Zou

et al. 2014

J of Applied Polymer Sci

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This study investigated the effects of drug and polymer molecular weight on release kinetics from poly (G-co-glycolic acid)-methoxypoly(ethyleneglycol) (PLGA-mPEG) microspheres. Bovine serum albumin (BSA, 66 kDa), lysozyme (LZ, 13.4 kDa), and vancomycin (VM, 1.45 kDa) were employed as the model drugs, and encapsulated in PLGA-mPEG microspheres of different molecular weight. Release of macromolecular BSA was mainly dependent on diffusion of drug at/ near the surface of the matrix initially and dependent on degradation of matrix at later stages, while, the small drug of vancomycin seemed to depend totally on diffusion for the duration of the release study. The release behavior of lysozyme was similar to bovine serum albumin, except a shorter lag period. PLGA-mPEG molecular weight also affected the release behavior of bovine serum albumin and lysozyme, but not obviously. PLGAmPEG microspheres in smaller molecular weight seemed to degrade more quickly to obtain a mass lose and matrix erosion, and thus, an accelerated release rate of bovine serum albumin and lysozyme. Vancomycin released much faster than bovine serum albumin and lysozyme, and exhibited no lag period, as it is thought to be diffusion-controlled. Besides, vancomycin showed no difference in release behavior as PLGA-mPEG molecular weight change.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of drug and polymer molecular weight on drug release from PLGA‐mPEG microspheres

Feng

Nie

Zou

et al. 2014

J of Applied Polymer Sci

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“…In a recent study, Katizawa et al reported that a S/O suspension containing hGH was prepared through the W/O emulsion-lyophilization process. Subsequently, a S/O/W emulsion was formed and solvent evaporation was performed to form novel biodegradable microparticles, resulting in high yields of hGH (Kakizawa et al, 2010). However, many researchers have recognized a secondary limitation that the release ratio of proteins from particles is generally very low and proteins are strongly retained in these polymeric particles, for periods exceeding several weeks, because high molecular weight emulsifiers are used.…”

Section: )mentioning

confidence: 99%

Solid-in-oil dispersion: A novel core technology for drug delivery systems

Tahara

Kamiya

Goto

2012

International Journal of Pharmaceutics

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“…Due to their properties in aqueous solution, which are caused by the interaction of intramolecular and intermolecular chains between the hydrophobic groups, they are widely used in oil and gas development, engineering materials, industrial coatings, sewage sludge, and drug controlled release [1,2], but their properties and structures can be greatly affected by salinity and temperature. Most studies have only revealed the effect of salinity on the viscosity of polymer solutions, but the effects on the microstructure and other rheological properties have rarely been reported [3,4].…”

Section: Introductionmentioning

confidence: 99%

Novel Hydrophobic Associating Polymer with Good Salt Tolerance

et al. 2018

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Abstract:A hydrophobic associating polymer named DiPHAM (acrylamide/sodium acrylamide-2-methylpropanesulfonic/sodium acrylate/N,N-di-n-dodecylacrylamide) with good salt tolerance was synthesized via photo-initiation polymerization. The critical association concentration (CAC) of DiPHAM was determined by viscosity changes to be 490 mg/L with different DiPHAM concentrations and particle sizes varied under such dynamic conditions. The influences of aqueous metal ions with different charges on its aqueous solution were investigated by measuring apparent viscosity, viscoelasticity, thixotropy, rheology, and particle size, and by SEM observation. The apparent viscosity of the DiPHAM solution was affected by metal ions to some extent, but the viscosity of the polymer can be still maintained at 55 mPa·s under 20 × 10 4 mg/L NaCl. Divalent metal ions show greater impact on DiPHAM aqueous solutions, but the polymer solutions showed resistance to the changes caused in viscosity, structure, and viscoelasticity by Ca 2+ and Mg 2+ ions. The salt tolerance of DiPHAM is due to the combination of hydrophobic association, the electrostatic shield, and double layer compression of the hydration shell. Increasing the ion concentration enhances the dehydration and further compresses the hydration shell, making the non-structural viscosity decrease, even "salting out". Measurements of rheological properties showed that DiPHAM solutions could maintain a relatively high viscosity (0.6%-71 mPa·s/0.3%-50 mPa·s) after 120 min of continuous shearing (170 s −1 ) at 140 • C. Under high-salinity (5000 mg/L Ca 2+ /3000 mg/L Mg 2+ ) conditions, the solution with 0.6 wt% DiPHAM still maintained a high viscosity (50 mPa·s/70 mPa·s) after continuously shearing for 120 min at 120 • C and 170 s −1 . The good salt tolerance of DiPHAM can lead to a variety of applications, including in fracturing fluids for enhanced oil recovery (EOR) and in sewage treatment.

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Controlled release of protein drugs from newly developed amphiphilic polymer-based microparticles composed of nanoparticles

Cited by 37 publications

References 26 publications

Effects of drug and polymer molecular weight on drug release from PLGA‐mPEG microspheres

Effects of drug and polymer molecular weight on drug release from PLGA‐mPEG microspheres

Solid-in-oil dispersion: A novel core technology for drug delivery systems

Novel Hydrophobic Associating Polymer with Good Salt Tolerance

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