Controlled release of paroxetine from chitosan/montmorillonite composite films

Altunkaynak, Funda; Okur, Müjgan; Saraçoğlu, Nurdan

doi:10.1016/j.jddst.2022.103099

Cited by 24 publications

(18 citation statements)

References 34 publications

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“…Values of n < 0.5 may be due to drug diffusion partially through swelling behavior. 30 As a result, the n value was decreased from 0.236 to 0.196 as the addition of AA increased. All n values were less than 0.5, which means those drug releases were caused by swelling behaviors of the film in PBS.…”

Section: Resultsmentioning

confidence: 97%

“…If the n value is approximately equal to 0.5, the drug-release mechanism is defined as a diffusion-controlled mechanism (Fickian diffusion). Values of n < 0.5 may be due to drug diffusion partially through swelling behavior . As a result, the n value was decreased from 0.236 to 0.196 as the addition of AA increased.…”

Section: Resultsmentioning

confidence: 99%

“…Values of n < 0.5 may be due to drug diffusion partially through swelling behavior. 30 As a result, the n value was decreased from 0.236 to 0.196 as the addition of AA increased.…”

Section: Drug-release Testing Of Dox-loaded Filmsmentioning

confidence: 97%

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Drug-Loaded Biocompatible Chitosan Polymeric Films with Both Stretchability and Controlled Release for Drug Delivery

et al. 2022

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Chitosan is a natural polysaccharide with the advantageous qualities of biocompatibility and biodegradability, and it has recently been spotlighted as a soft material for a sustainable society. Advantages such as these are in demand for application in various biomaterials. Although extensive studies have been conducted on the preparation of chitosan films, overcoming the problems of weak mechanical properties remains a significant barrier. In the present study, we developed stretchable doxorubicin-loaded biocompatible chitosan films by adding acetic acid in controlled concentrations. The stretchable properties of doxorubicin-loaded chitosan film at various concentrations of acetic acid were measured. Elongation to the point of breakage reached 27% with a high concentration of acetic acid, which could be described as high stretchability. The release ratio of doxorubicin from chitosan film reached 70% with a high acetic acid concentration. The cytotoxicity of doxorubicin-loaded chitosan films was measured, and cancer spheroids had completely collapsed after 7 days. According to the results of skin permeability testing, use of the doxorubicin-loaded chitosan film is a plausible choice for a drug sealant.

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Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

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Drug-Loaded Biocompatible Chitosan Polymeric Films with Both Stretchability and Controlled Release for Drug Delivery

et al. 2022

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“…It is also found that increasing the ratio of clay in the film decreased the release rate of the drug. [ 119 ] Solvent casting method was used for the synthesis of chitosan/montmorrillonite nanocomposite films for the release of ibuprofen. The film with 10% clay released the drug in a controlled pattern.…”

Section: Chitosan Films In Drug Delivery Applicationsmentioning

confidence: 99%

Chitosan‐Based Films in Drug Delivery Applications

2022

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The idea of controlled release of the pharmaceutical active ingredients in the human body has become a major thrust for designing sophisticated drug delivery systems. The mandatory requirement for developing these delivery vehicles is to support the delivery of pharmaceutical drugs in a pharmokinetically controlled manner. Though a variety of synthetic polymers address the above mentioned conditions, their toxicity and high cost have ultimately hampered their role. Consequently, natural polymers owing to their biocompatibility, biodegradability, and nontoxicity can be used for the successful designing of drug delivery supports. One such natural polymer extracted from crustaceans, is chitosan. Chitosan can be used in drug delivery in various forms like hydrogels, nanoparticles, nanofibers, films, etc. This review presents the properties of chitosan films and their pivotal role in various drug delivery approaches.

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“…Montmorillonite (MMT) is the most used clay from the smectite class to prepare CS/clay hydrogels or films. Recently, Altunkaynak et al [ 12 ] have prepared, by solvent casting method, CS/MMT composite films which can be used as controlled release systems of Paroxetine Hydrochloride. The composite films containing the sodium form of MMT exhibited a higher percentage of released drugs due to the increase of space between silicate layers, determining the increase of swelling capacity.…”

Section: Introductionmentioning

confidence: 99%

Development of Hybrid Materials Based on Chitosan, Poly(Ethylene Glycol) and Laponite® RD: Effect of Clay Concentration

Morariu¹,

Brunchi²,

Honciuc³

et al. 2023

Polymers

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In the context of increasing interest in biomaterials with applicability in cosmetics and medicine, this research aims to obtain and characterize some hybrid materials based on chitosan (CS) (antibacterial, biocompatible, and biodegradable), poly(ethylene glycol) (PEG) (non-toxic and prevents the adsorption of protein and cell) and Laponite® RD (Lap) (bioactive). The rheological properties of the starting dispersions were investigated and discussed related to the interactions developed between components. All samples exhibited gel-like properties, and the storage modulus of CS/PEG dispersion increased from 6.6 Pa to 657.7 Pa by adding 2.5% Lap. Structural and morphological characterization of the films, prepared by solution casting method, was performed by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), and polarized light microscopy (POM). These analyses proved the incorporation of Lap into CS/PEG films and revealed the morphological changes of the films by the addition of clay. Thereby, at the highest Lap concentration (43.8%), the “house of cards” structure formed by Lap platelets, which incorporate chitosan chains, as evidenced by SEM and POM. Two stages of degradation between 200 °C and 410 °C were evidenced for the films with Lap concentration higher than 38.5%, explained by the existence of a clay-rich phase (given by the clay network) and chitosan-rich one (due to the intercalation of chitosan in the clay network). CS/PEG film with 43.8% Lap showed the highest swelling degree of 240.7%. The analysis of the obtained results led to the conclusion that the addition of clay to the CS/PEG films increases their stability in water and gives them greater thermal stability.

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Controlled release of paroxetine from chitosan/montmorillonite composite films

Cited by 24 publications

References 34 publications

Drug-Loaded Biocompatible Chitosan Polymeric Films with Both Stretchability and Controlled Release for Drug Delivery

Drug-Loaded Biocompatible Chitosan Polymeric Films with Both Stretchability and Controlled Release for Drug Delivery

Chitosan‐Based Films in Drug Delivery Applications

Development of Hybrid Materials Based on Chitosan, Poly(Ethylene Glycol) and Laponite® RD: Effect of Clay Concentration

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