Controlled release of levonorgestrel from biodegradable poly(d,l-lactide-co-glycolide) microspheres: In vitro and in vivo studies

Wang, S.H.; Zhang, L.C.; Lin, Fang-Chi; Sa, Xu; Zuo, Jiao; Shao, Qun; Chen, G.S.; Zeng, Su

doi:10.1016/j.ijpharm.2005.05.038

Cited by 43 publications

(45 citation statements)

References 20 publications

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“…Controlled-release drug delivery systems have been becoming increasingly important, especially in biomedicine, in order to achieve an optimal therapeutic level and reduce side-effects. To obtain ideal release patterns, many strategies have been developed, for instance employing different emulsion methods (Wu et al, 2008) and modifying the encapsulated drugs directly (Al-Azzam et al, 2005;Wang et al, 2005;Tahara et al, 2008). Among these, PLGA microsphere/hydrogel combination systems could not only provide entrapped proteins a more 'friendly' environment, but also retard the initial burst release.…”

Section: Introductionmentioning

confidence: 99%

A one-step modified method to reduce the burst initial release from PLGA microspheres

Zheng

Liang

2010

Drug Delivery

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Section: Introductionmentioning

confidence: 99%

A one-step modified method to reduce the burst initial release from PLGA microspheres

Zheng

Liang

2010

Drug Delivery

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“…[9][10][11] Aliphatic polyester polymers degrade in to non-toxic monomers by bulk hydrolysis of the ester bonds, then avoiding the need for surgical removal so the risk of long term toxicity or a probable immunological reaction when compared with non degradable systems is also minimized. 12 Micro-encapsulation is a method of fabricating materials with valuable new properties in the pharmaceutical industry 13,14 and other fields; [15][16][17] it is one of the quality preservation techniques of sensitive substances. In current pharmacology, micro-encapsulation is employed as a masking technique and, in particular, to control and modify drug release.…”

Section: Introductionmentioning

confidence: 99%

Elaboration of Microspheres’ Capsules Based on Ethylcellulose and Synthesized Poly (Butylsuccinate) as Biodegradable Matrices for Drug Delivery of an Antithyroidian Agent

Chirani¹,

Lebig²,

Bouameur³

et al. 2017

IJPER

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Introduction:The present paper provides details of preparation of hardcapsules based on microspheres containing 2-aminothiazole as an antithyroidian agent and synthesized poly(butylsuccinate) (PBS) or ethylcellulose(EC10) as biodegradable matrices as well as the study of the drug delivery. Methods: A disintegration tests of these gelatinous capsules were done. The biodegradable synthesized polyester was characterized by infrared spectroscopy, nuclear magnetic resonance (mono and bidimentional H1NMR, 13CNMR) and by Differential Scanning Calorimetry (DSC). A viscosimetric study has been done in order to evaluate viscosimetric PBS's weight wich was calculated from Mark-Houwink equation. The microencapsulation of 2-aminothiazole was done using solvent evaporation technique. Results: Microspheres were spherical and the effects of varying emulsifiers and blades number on microspheres encapsulation efficiency were evaluated. A kinetic studies of releases of 2-aminothiazole in gastric pH were done in order to evaluate the best late effect and then the best formulation.

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“…studied the enzymatic hydrolysis of the pro-drug N-(2-hydroxypropyl)-methacrylamide using chymotripsyne as catalyst [12][13][14][15] . Moreover, the monolithic dosage forms were largely used such as co-precipitates 16 , cylindrical 17 or spherical [18][19][20] dosage forms, disks or tablets 18,[21][22] and micropsheres [23][24][25] .…”

Section: Introductionmentioning

confidence: 99%

3-aminopyridine release study from polymeric supports in homogeneous and heterogeneous media

et al. 2011

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Abstract:In order to control and modify the drug release, in one hand 3-aminopyridine as active agent was grafted via chemical azomethine bond on monomer then copolymerized with N-vinylpyrrolidone. The obtained supports were characterized and the drug release from these formulations was followed using UV-Vis spectrophotometer in homogeneous media at four different pH (pH=1.2, 4.0, 6.0 and 8.0) simulating the human digestive rout. The results showed that the hydrolysis of monomer and copolymer obeyed to the first order and the apparent kinetic constants were calculated. In the other hand, spherical dosage forms composed from Eudragit RL100 and the active agent or the copolymer support were prepared and tested to control the drug release. The heterogeneous kinetics were established successively in the four cited media. The drug release seemed that be governed by diffusion model according to the Fick's laws. So, the diffusivities were calculated and the results demonstrated that the drug release can be modified using these formulations.

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Controlled release of levonorgestrel from biodegradable poly(d,l-lactide-co-glycolide) microspheres: In vitro and in vivo studies

Cited by 43 publications

References 20 publications

A one-step modified method to reduce the burst initial release from PLGA microspheres

A one-step modified method to reduce the burst initial release from PLGA microspheres

Elaboration of Microspheres’ Capsules Based on Ethylcellulose and Synthesized Poly (Butylsuccinate) as Biodegradable Matrices for Drug Delivery of an Antithyroidian Agent

3-aminopyridine release study from polymeric supports in homogeneous and heterogeneous media

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