Elaboration of Microspheres’ Capsules Based on Ethylcellulose and Synthesized Poly (Butylsuccinate) as Biodegradable Matrices for Drug Delivery of an Antithyroidian Agent

Chirani, Soumia; Lebig, Mohamed Oussama; Bouameur, Sarah; Mouffok, Meriyem; Chirani, Naziha; Chafi, Nafa; Guemra, Kaddour

doi:10.5530/ijper.51.2s.53

Cited by 3 publications

(4 citation statements)

References 25 publications

(28 reference statements)

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“…In order to remove the residual monomers, the polymer obtained is heated at 200 °C in a 100 cc flask for three hours under high vacuum using a vacuum pump (max = 103 mm Hg). ( Chirani et al, 2017).…”

Section: Methodsmentioning

confidence: 99%

“…The obtained microspheres were determined in triplate. Several mathematic formula (Kczmarski and Bellot, 2003;Chirani et al, 2017) were used to calculate different characteristic parameters such as: the mean diameters (d10, d32 and d43), size distribution, d10 number mean diameter, d32 the diameter of sauter, (the volumesurface mean), d43 the weight mean diameter (the volume mean diameters) (Eq. 4-6).…”

Section: Determination Of the Encapsulation Efficiencymentioning

confidence: 99%

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Controlled release of amoxicillin from PMMA and poly(butylsuccinate) microspheres

Int¹

2019

Preprint

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This work focus on the study and the elaboration of microspheres based on amoxicillin (AMO), those microspheres were prepared through the oil/water emulsion evaporation technique. Polybutylene succinate (PBS) and Poly(methylmethacrylate) (PMMA) polymeric matrix were used with Tween 80 (T80) and Polyvinyl alcohol (PVA) as emulsifiers. These polymeric systems were analyzed by SEM, FTIR and optical microscopy. The conditions of the microspheres forming were varied and the preparation was performed by changing different parameters such as: the nature of the polymer, the stirring speed, organic solvent, surfactant nature, and concentration, which allows the study of their effect on encapsulation efficiency and drug release kinetics. These parameters affect strongly the size of microspheres, the drug content and the drug release, the latter is settled in an artificially reconstituted media of pH = 1.2 transcribed from the stomachal medium.

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Section: Methodsmentioning

confidence: 99%

Section: Determination Of the Encapsulation Efficiencymentioning

confidence: 99%

Controlled release of amoxicillin from PMMA and poly(butylsuccinate) microspheres

Int¹

2019

Preprint

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“…These systems provide a pH-dependent drug release mechanism. [20][21][22] In drug microencapsulation, [23][24][25] the most used class of hydrophobic polymers is cellulose derivatives including ethyl cellulose (EC) and cellulose acetate butyrate (CAB) for a prolonged release. 26 Jelvehgari et al have shown that CAB formulations exhibit enough buoyancy to reside in the stomach over a prolonged and slower drug release.…”

Section: Introductionmentioning

confidence: 99%

In vitro release study of 2-aminobenzothiazole from microspheres as drug carriers

et al. 2020

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The aim of the present study was the preparation of 2-aminobenzothiazole-loaded microspheres based on cellulose derivatives for controlled and prolonged release. Micro-encapsulation by the simple emulsion (O/W) solvent evaporation method was performed to prepare these formulations using two cellulose derivatives as matrices: ethyl cellulose (EC) and cellulose acetate butyrate (CAB). Optimization of the experimental parameters, such as the polymer/solvent ratio, the matrix type, stirring speed and the number of blades, was performed to obtain a high encapsulation efficiency of the drug. The effect of the selected parameters on microsphere characteristics, as well as the release rate was investigated. SEM images show that the obtained microparticles were spherical in shape. The effective entrapment of 2-amino-benzothiazole (2-ABZT) in the microspheres was confirmed by FTIR spectroscopy and XRD diffraction analysis. The encapsulation efficiency was improved when the polymer concentration increased reaching 89 %. Microspheres in the size range of 61-278 µm with EC and close to 113 µm with CAB were obtained by varying the process conditions. The in vitro release kinetics of the cation of 2-ABZT were established at 37 °C in simulated gastric medium pH 1.2 and the obtained data were analyzed according to the Fick law. The results showed that the surface morphology and encapsulation efficiency of the microspheres depended strongly on the polymer/solvent ratio and the release rate could be controlled by adjusting the process conditions.

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“…The function of microcapsules into diversity therapeutic applications had led to the layout of many different microencapsulation methods, each specifically engineered in view of the requirements of each drug's properties and production setup. 5,6 Microencapsulation can be benefited in modifying and retarding drug release and improving its absorption. In pharmaceutical sustained release formulations, the advantage of microcapsules lies in the wide distribution throughout the Gastrointestinal tract (GIT).…”

Section: Introductionmentioning

confidence: 99%

Effect of Ethyl Cellulose Content on Release Profile and Pharmacodynamics of Fenoprofen Microparticles

Aboueisha¹,

Gad²,

Khalil³

et al. 2019

IJPER

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Introduction: Fenoprofen calcium (FC) is a non-steroidal anti-inflammatory drug and due to its short half-life, high absorption, extensive metabolism and adverse effect, sustained release formulation of FC is desired. Objective: this study was to develop sustained release microcapsules of FC to obtain better drug delivery. Material and Methods: Different formulae of FC microcapsules were prepared by o/w emulsion solvent evaporation method using Ethyl cellulose (EC) in three different ratios. The processed microcapsules were evaluated in-vitro for production yield, entrapment efficiency, micromeritic properties and thermal characteristics and in-vivo for its pharmacodynamics. Results: In-vitro release studies of formulae H1 and H3 showed regression coefficient (r) value in the Higuchi diffusion model of 0.967 and 0.946 respectively, suggesting diffusion mechanism release from these forms. While marketed capsules and H2 microcapsules showed regression coefficient value in the zero-order model (0.985 and 0.985 respectively), suggesting non-linear release. In-vivo, the carrageenan-induced hind paw edema was induced in rats; the area under the inhibition of inflammation percentage-time curve (AUC0-24) showed that formula H3 possesses the highest therapeutic efficiency comparing with marketed capsules followed by formula H1 and finally H2. Moreover, in hot plate test in mice, there were highly significant increases in the mean reaction time in groups H2 and H3 over the marketed capsule at 12h interval (p<0.001). Conclusion: FC loaded EC microcapsule H3 produced a sustained and effective drug release over a prolonged timeframe that led to greater therapeutic efficacy.

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Elaboration of Microspheres’ Capsules Based on Ethylcellulose and Synthesized Poly (Butylsuccinate) as Biodegradable Matrices for Drug Delivery of an Antithyroidian Agent

Cited by 3 publications

References 25 publications

Controlled release of amoxicillin from PMMA and poly(butylsuccinate) microspheres

Controlled release of amoxicillin from PMMA and poly(butylsuccinate) microspheres

In vitro release study of 2-aminobenzothiazole from microspheres as drug carriers

Effect of Ethyl Cellulose Content on Release Profile and Pharmacodynamics of Fenoprofen Microparticles

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