Controlled release of human growth hormone from a biodegradable pH/temperature-sensitive hydrogel system

Huynh, Cong Truc; Kang, Seong Woo; Li, Yang; Kim, Bong Sup; Lee, Sang Soo

doi:10.1039/c1sm05919j

Cited by 59 publications

(54 citation statements)

References 58 publications

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“…The addition of urea bonding enhanced the mechanical strength as well as prolonged the degradation time, which was promising for long-term applications [110]. In contrast, ester bonding in the multiblock and triblock poly(b-amino ester urethane) served as the hydrolytically degradable factor, which enhanced the degradation rate of the hydrogels [111,112]. Using 4-arm polyethylene glycol to build the star-shaped copolymer led to gelation even with low molecular weight polymers [113].…”

Section: Ph-sensitive Hydrogelsmentioning

confidence: 99%

“…Aqueous solutions of these short chain gelators have exhibited a pH-and temperature-responsive sol-gel transition, with the gel windows occurring under physiological conditions. For therapeutic applications, these polymers and oligomers may be potential carriers for the delivery of various types of drugs or proteins such as doxorubicin [111,118], human growth hormone [112], lidocaine [115], chlorambucil [109,113], FITC-BSA [110], paclitaxel [108], and insulin [117].…”

Section: Ph-sensitive Hydrogelsmentioning

confidence: 99%

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Injectable polymeric hydrogels for the delivery of therapeutic agents: A review

Nguyễn

Huynh

Park

et al. 2015

European Polymer Journal

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203

120

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Section: Ph-sensitive Hydrogelsmentioning

confidence: 99%

Section: Ph-sensitive Hydrogelsmentioning

confidence: 99%

Injectable polymeric hydrogels for the delivery of therapeutic agents: A review

Nguyễn

Huynh

Park

et al. 2015

European Polymer Journal

Self Cite

203

120

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“…Quan et al [214] designed thermo-responsive micelles from a poly(N-acroyloxysuccinimide)-b-poly other groups [208]. B Photographs of phase transitions of PAEU-PEG-PAEU copolymers with respect to pH or temperature, and hGH concentration in blood of SD rats after injection of hGH solution, and hGH-gel formulation [256]. C Scheme depicting concept of pHresponsive PMPC-PDPA vesicles used for gene transfection and the cell viability assay and enhanced GFP expression [234] (N-isopropylacrylamide)-b-poly(caprolactone) (PNAS-bPNiPAAm-b-PCL) triblock copolymer for the delivery of DOX to HeLa cells.…”

Section: Delivery Of Low Molecular Weight Drugsmentioning

confidence: 99%

“…As an example, poly(ethylene glycol) (PEG) and poly(b-amino ester urethane) (PAEU) copolymer undergo pH-and temperature-induced gelation under physiological conditions [229]. These materials were used to deliver human growth hormone (hGH) to rats.…”

Section: Protein and Enzyme Deliverymentioning

confidence: 99%

Stimuli-Responsive Polymers and Their Applications in Nanomedicine

et al. 2012

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This review focuses on smart nano-materials built of stimuli-responsive (SR) polymers and will discuss their numerous applications in the biomedical field. The authors will first provide an overview of different stimuli and their corresponding, responsive polymers. By introducing myriad functionalities, SR polymers present a wide range of possibilities in the design of stimuli-responsive devices, making use of virtually all types of polymer constructs, from self-assembled structures (micelles, vesicles) to surfaces (polymer brushes, films) as described in the second section of the review. In the last section of this review the authors report on some of the most promising applications of stimuli-responsive polymers in nanomedicine. In particular, we will discuss applications pertaining to diagnosis, where SR polymers are used to construct sensors capable of selective recognition and quantification of analytes and physical variables, as well as imaging devices. We will also highlight some examples of responsive systems used for therapeutic applications, including smart drug delivery systems (micelles, vesicles, dendrimers...) and surfaces for regenerative medicine.

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“…L-alanine and D-alanine, acryloyl chloride, α-CD, and PEGDA (M n , 575; ρ, 1.12 g/cm 3 ) were purchased from Aladdin (China). Potassium dihydrogen phosphate (KH 2 PO 4 ) was obtained from J&K Chemical Technology (Beijing, China).…”

Section: Experimental Materialsmentioning

confidence: 99%

Chiral, pH responsive hydrogels constructed by N -Acryloyl-alanine and PEGDA/α -CD inclusion complex: preparation and chiral release ability

Liu

Cheng

Deng

et al. 2015

Polym. Adv. Technol.

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Chiral, pH-responsive hydrogels are constructed by poly(ethylene glycol) diacrylate/α-cyclodextrin (PEGDA/α-CD) inclusion complex and L-N-acryloyl-alanine or D-N-acryloyl-alanine (L-NAA or D-NAA) by an effective free radical polymerization approach. PEGDA containing two C=C end groups was used simultaneously to introduce α-CD units in the resulting hydrogels and to serve as a cross-linking agent, by which forming the designed hydrogels in quantitative yield. Hydrophilic α-CD moieties acted as pore-forming agent, while the L(D)-NAA-based polymer chains bearing -COOH groups enabled the hydrogels to display remarkable swelling-deswelling behavior in response to pH variation. The chiral NAA monomer-derived polymer chains rendered the hydrogels with intriguing optical activity, according to circular dichroism spectra. Scanning electron microscopy revealed the uniformly porous microstructures of hydrogels. More remarkably, the L-NAA-based hydrogels preferentially adsorbed trans-4-hydroxy-Dproline and preferentially released trans-4-hydroxy-L-proline, while D-NAA-based hydrogels provided opposite results. The hydrogels also demonstrated remarkable enantioselective release ability towards chiral drug ibuprofen.

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Controlled release of human growth hormone from a biodegradable pH/temperature-sensitive hydrogel system

Cited by 59 publications

References 58 publications

Injectable polymeric hydrogels for the delivery of therapeutic agents: A review

Injectable polymeric hydrogels for the delivery of therapeutic agents: A review

Stimuli-Responsive Polymers and Their Applications in Nanomedicine

Chiral, pH responsive hydrogels constructed by N -Acryloyl-alanine and PEGDA/α -CD inclusion complex: preparation and chiral release ability

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