Injectable polymeric hydrogels for the delivery of therapeutic agents: A review

Light-Triggered RNA Release and Induction of Hmsc Osteogenesis Via Photodegradable, Dual-Crosslinked Hydrogels

“…After 4 weeks, 27% siRNA released from the 'No UV' 22.5% (w/v) hydrogels ( Figure 5C) compared to 59% from the 'No UV' 15% (w/v) hydrogels ( Figure 5B). These findings are in agreement with the literature as increasing hydrogel concentration and/or crosslinking density have been reported to decrease the release rate of loaded bioactive molecules such as siRNA, anticancer drugs and proteins from the hydrogel networks [47,57,60,63,71]. Similar to the 15% (w/v) hydrogels, siRNA release was accelerated when the 22.5% (w/v) hydrogels were exposed to external UV light Research Article Huynh, Nguyen, Naris, Tonga, Rotello & Alsberg ( Figure 5C, 'UV-3': 20 mW/cm 2 for 10 min at each release time point or 'UV-4': 20 mW/cm 2 for 30 min weekly).…”

“…Bioactive factors and cells can easily be encapsulated within hydrogels for tissue engineering applications [2,5,6,38,[55][56][57][58]. The degradation of hydrogel biomaterial platforms increases their network pore size, which regulates the release of loaded bioactive molecules, creates free space for newly forming tissues and enhances transport of oxygen and nutrients to encapsulated cells as well as removal of metabolic waste.…”

“…Hydrogels hold great potential in biomedical and pharmaceutical applications because bioactive factors can be encapsulated within them and subsequently delivered in a localized and controlled manner at desired anatomic locations [38,[55][56][57]. For example, they have been employed as depots for the delivery of anticancer drugs [59][60][61], genetic materials [62], and proteins [63][64][65].…”

“…Polymeric hydrogel biomaterials are three-dimentional chemically or physically crosslinked hydrophilic polymer networks that can absorb and retain large quantities of water [2,38,[55][56][57][58]. Hydrogels hold great potential in biomedical and pharmaceutical applications because bioactive factors can be encapsulated within them and subsequently delivered in a localized and controlled manner at desired anatomic locations [38,[55][56][57].…”

Photothermal-modulated drug delivery and magnetic relaxation based on collagen/poly(γ-glutamic acid) hydrogel

“…[1][2][3][4][5][6][7][8][9] By modulating the chemical or physical interactions between natural and/or synthetic polymeric materials, various types of hydrogels have been developed. [10][11][12][13][14][15] Although the chemical gelation strategy using synthetic polymers shows advantages, such as the systematic control of molecular structure and resultant hydrogel properties, toxicity issues still limit their wide adoption in clinical fields.…”