Controlled release of drugs with nanostructured capsules in microdroplets

He, Yang; Cheng, Wen-Chuan; Zhao, Yafei; Lvov, Yuri; Que, Long

doi:10.1109/icsens.2012.6411086

Cited by 4 publications

(3 citation statements)

References 14 publications

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“…Hence, high throughput screen of the drug effects on single cells under a variety of different conditions might be possible in an efficient manner. In addition, compared to the previously reported work, 11,12 this platform also provides droplet chambers to ensure droplets to become stationary, thereby enabling the observation of the drug effects for an extended period of time, which will greatly benefit the drug screen and discovery research.…”

Section: B Controlled Drug Release In Dropletsmentioning

confidence: 99%

“…The DWlCs have been fabricated by a LbL nanoassembly process. 12 Briefly, the solutions of PAH (2 mg/ml), PSS (2 mg/ml), FITC, and drug (2 mg/ml) are prepared. The process starts with the drug model (MnCO 3 lPs), and they are coated by a PAH layer and then by a PSS layer.…”

Section: A Design and Fabrication Of The Microfluidic Devicementioning

confidence: 99%

“…10,11 However, in this technology, the drug dose applied on the cells is rapid, immediate, and fixed; the studies of the controlled drug dose effect on cells cannot be achieved. In another recent work, the controlled-drug release in a droplet has been demonstrated, 12,13 showing a great promise for realizing the drug effect analysis on single cells in a controlled manner on a microdevice. In this demonstration, drugs (i.e., Cucurmin) with nanostructured capsules are encapsulated in droplets by a microfluidic device.…”

Section: Introductionmentioning

confidence: 99%

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A microfluidic chip for controlled release of drugs from microcapsules

Cheng

Chang

et al. 2013

Biomicrofluidics

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A new microfluidic device with liquid-droplet merging and droplet storage functions for the controlled release of drugs from microcapsules is reported. A switching channel is designed and integrated within the microfluidic device, facilitating the generation and capturing of uniform droplets by the storage chambers. The drug model is the MnCO 3 microparticle, which is encapsulated by a microcapsule and fabricated using a simple layer-by-layer nanoassembly process. The merging function is used for dynamically adding the control solution into the droplets, which contain drugs within the microcapsules (DWlCs) and water. The storage chambers are used for collecting DWlCs-laden droplets so that the controlled-drug release in specific droplets can be monitored for an extended period of time, which has been experimentally implemented successfully. This technology could offer a promising technical platform for the long-term observation and studies of drug effects on specific cells in a controlled manner, which is especially useful for single cell analysis. V C 2013 AIP Publishing LLC.

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Section: B Controlled Drug Release In Dropletsmentioning

confidence: 99%

Section: A Design and Fabrication Of The Microfluidic Devicementioning

confidence: 99%