A microfluidic chip for controlled release of drugs from microcapsules

Cheng, Wen-Chuan; He, Yang; Chang, An-Yi; Que, Long

doi:10.1063/1.4829776

Cited by 24 publications

(17 citation statements)

References 25 publications

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“…10 For example, it could be particularly useful for high value added materials since only a small amount of sample is needed, hence, the investigation of microparticles that are commonly administered in capsules can be studied. 13 Another example considers the potential to test unique 3D printed formulations designed for individual patients; such delivery methods are becoming possible in this industrial sector. 14 Drug release studies are of great importance when it comes to the identification of new candidates.…”

Section: Introductionmentioning

confidence: 99%

Attenuated total reflection-Fourier transform infrared spectroscopic imaging of pharmaceuticals in microfluidic devices

2016

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The poor aqueous solubility of many active pharmaceutical ingredients presents challenges for effective drug delivery. In this study, the combination of attenuated total reflection (ATR)-FTIR spectroscopic imaging with specifically designed polydimethylsiloxane microfluidic devices to study drug release from pharmaceutical formulations has been developed. First, the high-throughput analysis of the dissolution of micro-formulations studied under flowing conditions has been introduced using a model formulation of ibuprofen and polyethylene glycol. The behaviour and release of the drug was monitored in situ under different pH conditions. In contrast to the neutral solution, where both the drug and excipient dissolved at a similar rate, structural change from the molecularly dispersed to a crystalline form of ibuprofen was characterised in the obtained spectroscopic images and the corresponding ATR-FTIR spectra for the experiments carried out in the acidic medium. Further investigations into the behaviour of the drug after its release from formulations (i.e., dissolved drug) were also undertaken. Different solutions of sodium ibuprofen dissolved in a neutral medium were studied upon contact with acidic conditions. The phase transition from a dissolved species of sodium ibuprofen to the formation of solid crystalline ibuprofen was revealed in the microfluidic channels. This innovative approach could offer a promising platform for high-throughput analysis of a range of micro-formulations, which are of current interest due to the advent of 3D printed pharmaceutical and microparticulate delivery systems. Furthermore, the ability to study dissolved drug in solution under flowing conditions can be useful for the studies of the diffusion of drugs into tissues or live cells.

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Section: Introductionmentioning

confidence: 99%

Attenuated total reflection-Fourier transform infrared spectroscopic imaging of pharmaceuticals in microfluidic devices

2016

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“…The droplet generator forms cell-laden collagen droplets. The c-channel is designed to prevent any air bubbles or non-uniform droplets from entering and occupying the chambers at the beginning of the operation of the device [ 6 , 7 ]. Once the uniform droplet generation is established, the c-channel is closed, and the outlet of the chambers is open.…”

Section: Design Operational Principle and Fabrication Of The Dropmentioning

confidence: 99%

“…As a result, the droplets will flow toward the chambers, thereby entering and occupying them one by one. It should be noted that while this type of chip has been used for other applications [ 6 ], it is for the first time to be used to generate 3D microtissues and study the migration of the cells.…”

Section: Design Operational Principle and Fabrication Of The Dropmentioning

confidence: 99%

High Throughput Studies of Cell Migration in 3D Microtissues Fabricated by a Droplet Microfluidic Chip

et al. 2016

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Arrayed three-dimensional (3D) micro-sized tissues with encapsulated cells (microtissues) have been fabricated by a droplet microfluidic chip. The extracellular matrix (ECM) is a polymerized collagen network. One or multiple breast cancer cells were embedded within the microtissues, which were stored in arrayed microchambers on the same chip without ECM droplet shrinkage over 48 h. The migration trajectory of the cells was recorded by optical microscopy. The migration speed was calculated in the range of 3–6 µm/h. Interestingly, cells in devices filled with a continuous collagen network migrated faster than those where only droplets were arrayed in the chambers. This is likely due to differences in the length scales of the ECM network, as cells embedded in thin collagen slabs also migrate slower than those in thick collagen slabs. In addition to migration, this technical platform can be potentially used to study cancer cell-stromal cell interactions and ECM remodeling in 3D tumor-mimicking environments.

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“…Yet, the existing investigations mainly concentrate on the kinetics of biochemical reactions inside the trapped droplets, 12,18,[23][24][25] and an understanding of the fundamental mechanism of nonlinear dynamics in the MTN is still lacking. Additionally, the two-phase ow rate range in which sequentially uniform trapping occurs is narrow in the reported studies on trapping the droplet train, which severely limits the applicability of MTN-based microuidics techniques.…”

Section: 22mentioning

confidence: 99%

Trapping a moving droplet train by bubble guidance in microfluidic networks

et al. 2018

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Trapping a train of moving droplets into preset positions within a microfluidic device facilitates the longterm observation of biochemical reactions inside the droplets. In this paper, a new bubble-guided trapping method, which can remarkably improve the limited narrow two-phase flow rate range of uniform trapping, was proposed by taking advantage of the unique physical property that bubbles do not coalescence with two-phase fluids and the hydrodynamic characteristic of large flow resistance of bubbles. The flow behaviors of bubble-free and bubble-guided droplet trains were compared and analyzed under the same two-phase flow rates. The experimental results show that the droplets trapped by bubble-free guided trapping exhibit the four trapping modes of sequentially uniform trapping, nonuniform trapping induced by break-up and collision, and failed trapping due to squeezing through, and the droplets exhibit the desired uniform trapping in a relatively small two-phase flow rate range.Compared with bubble-free guided droplets, bubble-guided droplets also show four trapping modes.However, the two-phase flow rate range in which uniform trapping occurs is increased significantly and the uniformity of the trapped droplet array is improved. This investigation is beneficial to enhance the applicability of microfluidic chips for storing droplets in a passive way.

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A microfluidic chip for controlled release of drugs from microcapsules

Cited by 24 publications

References 25 publications

Attenuated total reflection-Fourier transform infrared spectroscopic imaging of pharmaceuticals in microfluidic devices

Attenuated total reflection-Fourier transform infrared spectroscopic imaging of pharmaceuticals in microfluidic devices

High Throughput Studies of Cell Migration in 3D Microtissues Fabricated by a Droplet Microfluidic Chip

Trapping a moving droplet train by bubble guidance in microfluidic networks

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